ID   WDR12_CULQU             Reviewed;         425 AA.
AC   B0W517;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=CPIJ001500;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDS34583.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EDS34583.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; DS231840; EDS34583.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001843801.1; XM_001843749.1.
DR   AlphaFoldDB; B0W517; -.
DR   SMR; B0W517; -.
DR   STRING; 7176.CPIJ001500-PA; -.
DR   GeneID; 6033337; -.
DR   KEGG; cqu:CpipJ_CPIJ001500; -.
DR   VEuPathDB; VectorBase:CPIJ001500; -.
DR   VEuPathDB; VectorBase:CQUJHB008532; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B0W517; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..425
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369554"
FT   REPEAT          106..143
FT                   /note="WD 1"
FT   REPEAT          145..187
FT                   /note="WD 2"
FT   REPEAT          194..233
FT                   /note="WD 3"
FT   REPEAT          258..296
FT                   /note="WD 4"
FT   REPEAT          298..337
FT                   /note="WD 5"
FT   REPEAT          343..383
FT                   /note="WD 6"
FT   REPEAT          387..425
FT                   /note="WD 7"
FT   REGION          13..94
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          227..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  47350 MW;  446B5B842824A5C7 CRC64;
     MALKITGKAE GQLQLHLITK QKQFAVPDVP YSIRANVSTK ELNVLVNTLL KDAGNAEAGK
     VEFDFLLNGE FPLGQHLKER DVSFEDTVEL EYVERYPAPE PQDCLLHDDW VSAVEARDNW
     ILTGCYDNTL NLWTTKGKHK LTIPGHIAPV KGVTWISLDE EKGVFASASQ DQTVMLWEWN
     VAANSVECVQ VCKGHERGVD CIAANGSKTK MATGSWDTML KIWSTDVRSG GGDSEPSTSK
     RQKLDQGSAR TPLMTLAGHR ECISGVQWID DNTLVTSSWD HTIKIWDLAL NGIKSEISGN
     KSFFDLSYSK LNGLIITASP DKNLRLYDPK SNQGTLVKNT YLGHTQWVQS VRWSTTNEYL
     FVSGAYDNHV KLWDYRSPKA PIFELIGHED KVLACDWSNP RFILSGGSDN SVRVFKSKIA
     IGGEK