VSI10_MOUSE
ID VSI10_MOUSE Reviewed; 558 AA.
AC D3YX43;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 10;
DE Flags: Precursor;
GN Name=Vsig10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC110234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS19603.2; -.
DR RefSeq; NP_001028483.2; NM_001033311.3.
DR AlphaFoldDB; D3YX43; -.
DR STRING; 10090.ENSMUSP00000107598; -.
DR GlyGen; D3YX43; 7 sites.
DR PhosphoSitePlus; D3YX43; -.
DR MaxQB; D3YX43; -.
DR PaxDb; D3YX43; -.
DR PeptideAtlas; D3YX43; -.
DR PRIDE; D3YX43; -.
DR ProteomicsDB; 275191; -.
DR Antibodypedia; 3044; 34 antibodies from 15 providers.
DR Ensembl; ENSMUST00000111967; ENSMUSP00000107598; ENSMUSG00000066894.
DR GeneID; 231668; -.
DR KEGG; mmu:231668; -.
DR UCSC; uc008zfn.1; mouse.
DR CTD; 54621; -.
DR MGI; MGI:2448533; Vsig10.
DR VEuPathDB; HostDB:ENSMUSG00000066894; -.
DR eggNOG; ENOG502R53I; Eukaryota.
DR GeneTree; ENSGT00940000159876; -.
DR InParanoid; D3YX43; -.
DR OMA; PMVEWWF; -.
DR OrthoDB; 1221933at2759; -.
DR PhylomeDB; D3YX43; -.
DR TreeFam; TF334050; -.
DR BioGRID-ORCS; 231668; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Vsig10; mouse.
DR PRO; PR:D3YX43; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; D3YX43; protein.
DR Bgee; ENSMUSG00000066894; Expressed in left colon and 141 other tissues.
DR ExpressionAtlas; D3YX43; baseline and differential.
DR Genevisible; D3YX43; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..558
FT /note="V-set and immunoglobulin domain-containing protein
FT 10"
FT /id="PRO_0000395114"
FT TOPO_DOM 21..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..558
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 37..140
FT /note="Ig-like C2-type 1"
FT DOMAIN 144..235
FT /note="Ig-like C2-type 2"
FT DOMAIN 248..327
FT /note="Ig-like C2-type 3"
FT DOMAIN 332..420
FT /note="Ig-like C2-type 4"
FT REGION 477..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..503
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..124
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 174..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 265..308
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 349..404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 558 AA; 60522 MW; 0320D8719AC7934A CRC64;
MAGLRVLLCL GALLARQGSA GLQLLLNPSR ANLSVRPNSE VLPGIHPDLE AVAIGEVHDN
VTLRCGSASG SRGLVTWYRN DSEPAFLVSF NSSLPPAAPR FSLEDAGALR IEALRLEDDG
NYTCQEVLNE THWFPVRLRV ASGPAYVEVN ISATGTLPNG TLYAARGSQV DFNCCSAAQP
PPEVEWWIQT HSIPEFLGKN LSANSFTLML MSQNLQGNYT CSATNVLSGR QRKVTTELLV
YWPPPSAPQC SVEVSSESTT LELACNWDGG YPDPTFLWTE EPGGTIMGNS KLQTLSPAQL
LEGKKFKCVG NHILGPESGA SCVVKLSSPL LPSQPMRTCF VGGNVTLTCE VSGANPPARI
QWLRNLTQPA IQPSSHYIIT QQGQSSSLTI HNCSQDLDEG FYYCQAENLV GVRATNIWLS
VKEPLNIGGI VGTVVSLLLL GLAVVSGLTL YYSPAFWWKG GSTFRGQDMG DVMVLVDSEE
EEEEEEEEEE KEDVAEEVEQ ETNETEELPK GISKHGHIHR VTALVNGNLD RMGNGFQEFQ
DDSDGQQSGI VQEDGKPV
