ID   VRTR2_PENAE             Reviewed;         836 AA.
AC   D7PHY7;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Transcription factor vrtR2 {ECO:0000303|PubMed:20534346};
DE   AltName: Full=Viridicatumtoxin synthesis protein R2 {ECO:0000303|PubMed:20534346};
GN   Name=vrtR2 {ECO:0000303|PubMed:20534346};
OS   Penicillium aethiopicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=36650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=IBT 5753;
RX   PubMed=20534346; DOI=10.1016/j.chembiol.2010.03.015;
RA   Chooi Y.H., Cacho R., Tang Y.;
RT   "Identification of the viridicatumtoxin and griseofulvin gene clusters from
RT   Penicillium aethiopicum.";
RL   Chem. Biol. 17:483-494(2010).
RN   [2]
RP   BIOTECHNOLOGY.
RX   PubMed=19168978; DOI=10.1038/ja.2008.84;
RA   Zheng C.J., Yu H.E., Kim E.H., Kim W.G.;
RT   "Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11.";
RL   J. Antibiot. 61:633-637(2008).
RN   [3]
RP   BIOTECHNOLOGY.
RX   PubMed=27049441; DOI=10.1038/ja.2016.35;
RA   Inokoshi J., Nakamura Y., Komada S., Komatsu K., Umeyama H., Tomoda H.;
RT   "Inhibition of bacterial undecaprenyl pyrophosphate synthase by small
RT   fungal molecules.";
RL   J. Antibiot. 69:798-805(2016).
CC   -!- FUNCTION: Probable transcription factor that regulates expression of
CC       the gene cluster that mediates the biosynthesis of viridicatumtoxin, a
CC       tetracycline-like fungal meroterpenoid with a unique, fused
CC       spirobicyclic ring system (PubMed:20534346).
CC       {ECO:0000269|PubMed:20534346}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- BIOTECHNOLOGY: Viridicatumtoxin and its derivative, viridicatumtoxin B,
CC       exhibit anti-methicillin-resistant Staphylococcus aureus (anti-MRSA)
CC       activity (PubMed:19168978). Moreover, viridicatumtoxin and a C2 acetyl
CC       analog, spirohexaline, have been demonstrated to inhibit bacterial
CC       undecaprenyl diphosphate synthase, a potential new target for
CC       antibiotic development (PubMed:27049441). {ECO:0000269|PubMed:19168978,
CC       ECO:0000269|PubMed:27049441}.
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DR   EMBL; GU574477; ADI24939.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7PHY7; -.
DR   SMR; D7PHY7; -.
DR   PRIDE; D7PHY7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..836
FT                   /note="Transcription factor vrtR2"
FT                   /id="PRO_0000436818"
FT   DNA_BIND        37..63
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  92125 MW;  2BE8F95D5FA7F81B CRC64;
     MPSLSSKTST MQRSCRPQMS ACPNQQQKDR PVPQLSCVLC RDRKLKCDKL DPCSNCTSSG
     VACTPIYRPR LPRGRHARTV QTKASTPPDT RRRGSSNEST TAPAPDDGGL GTHIDQLDNL
     VQDREVSKLG LSGEGNGLQE LISLVSDETM PATAWSTHCF GTISRILSSR IRRLESLVQE
     TARIQTPKRA RKPMTPVVVQ WYSAPLAGCN WNRMVVQTPQ GLEVQQFPAP PTSYSARRSP
     ELSGNDIWAD LMDHDMHDPP QYNALELPPD LTNEGGVDNM GSSGRDDPIN NGFNALRLLG
     INNSLSPSFI SLPRDRLSAS KLCQVYLQNV DPIIKILHRP SLSRWMVDGA PTYLGSSEDD
     YAVKALESAV CYTAANTMTE HQCQAAFQKT KSSIMAVRRK MCEDALENAG LLTTRDMTVL
     QAFILYLVTP TDLSKIGRRS EDKDTAVWAL VALAIRLIKA MGLNQEPSEG ARKGESFFQQ
     QLRLRLWLTA CLIDLQASFA QATDPLITHR DAACAVPYVA NINDSDFDVD TAHPVASHEE
     LTDTTFALVT YRVQVAGRLF NFGPGCSTAA ERHKLAQEVQ QQVFTLLHYC DPESSSYAWF
     TWHSTQSIIF AVRLSELLPF RCGQPGGHVP PPSPRAEGDT TLLWRALQNL EKAQLIRADP
     RGDGFRWYIT TPWLALSTAI SECNSCTDVA LVCRAWPVIE ISYRQHEELQ ISDECQLPQG
     PLVHLMNKTR EKLAPLLQEG GARLSDSQTV DRASADSLQP PVPVGSIPID PLLTNGSLGA
     DTAMSEASSI GSLPPFEQQC WKQMTMPTDG APVRDGVVFT SELYNPLQSD FLNSHG