ID   VR105_RAT               Reviewed;         311 AA.
AC   Q62850;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Vomeronasal type-1 receptor 105;
DE   AltName: Full=Pheromone receptor VN1;
DE   AltName: Full=Vomeronasal type-1 receptor 51;
DE   AltName: Full=Vomeronasal type-1 receptor A1;
DE            Short=Vomeronasal receptor 1;
GN   Name=Vom1r105; Synonyms=Vmn1r51, Vnr1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAA92007.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAA92007.1};
RC   TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAA92007.1};
RX   PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA   Dulac C., Axel R.;
RT   "A novel family of genes encoding putative pheromone receptors in
RT   mammals.";
RL   Cell 83:195-206(1995).
CC   -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC       social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC       ECO:0000269|PubMed:7585937}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC       organ. Only one pheromone receptor gene may be expressed in a
CC       particular neuron. Not expressed in the main olfactory epithelium.
CC       {ECO:0000269|PubMed:7585937}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA92007.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U36785; AAA92007.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_775136.1; NM_173113.1.
DR   AlphaFoldDB; Q62850; -.
DR   SMR; Q62850; -.
DR   STRING; 10116.ENSRNOP00000039516; -.
DR   GlyGen; Q62850; 1 site.
DR   PaxDb; Q62850; -.
DR   GeneID; 100312735; -.
DR   UCSC; RGD:708382; rat.
DR   CTD; 100312735; -.
DR   RGD; 708382; Vom1r105.
DR   eggNOG; ENOG502SNRJ; Eukaryota.
DR   InParanoid; Q62850; -.
DR   PRO; PR:Q62850; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; PTHR24062; 1.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Vomeronasal type-1 receptor 105"
FT                   /id="PRO_0000239956"
FT   TOPO_DOM        1..17
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        86..173
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   311 AA;  35377 MW;  8498FEC174EF2066 CRC64;
     MMNKNSRLYT DSNIRNTFFA EIGIGVSANS LLLLFNIFKL ICGQRSRLTD LPIGLLSLIN
     LLMLLMTAFI ATDTFISWRG WDDIICKSLL YLYRTFRGLS LCTSCLLSVL QAIILSPRSS
     CLAKFKHKPS HHISCAILSL SVLYMFISSH LLVSIIATPN LTTNDFIHVT QWCSILPMSY
     LMQSMFSTLL AIRDVFLISL MVLSTWYMVA LLCRHRKQTR HLQGTSLSPK ASPEQRATRS
     ILMLMSLFVL MSVFDSIVCS SRTMYLNDPI SYSYQLFMVH IYATVSPFVF IVTEKHIVNS
     LRSMCVKVMN V