ID   VPS35_DICDI             Reviewed;         781 AA.
AC   Q54C24;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Vacuolar protein sorting-associated protein 35;
GN   Name=vps35; ORFNames=DDB_G0293218;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays a role in vesicular protein sorting. Component of the
CC       membrane-associated retromer complex which is essential in endosome-to-
CC       Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be
CC       involved in cargo selection. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a retromer subcomplex consisting of vps29, vps26
CC       and vps35. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome
CC       membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305};
CC       Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the VPS35 family. {ECO:0000305}.
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DR   EMBL; AAFI02000200; EAL60808.1; -; Genomic_DNA.
DR   RefSeq; XP_629242.1; XM_629240.1.
DR   AlphaFoldDB; Q54C24; -.
DR   SMR; Q54C24; -.
DR   STRING; 44689.DDB0234193; -.
DR   PaxDb; Q54C24; -.
DR   EnsemblProtists; EAL60808; EAL60808; DDB_G0293218.
DR   GeneID; 8629124; -.
DR   KEGG; ddi:DDB_G0293218; -.
DR   dictyBase; DDB_G0293218; vps35.
DR   eggNOG; KOG1107; Eukaryota.
DR   HOGENOM; CLU_005836_1_0_1; -.
DR   InParanoid; Q54C24; -.
DR   OMA; WWVVENP; -.
DR   PhylomeDB; Q54C24; -.
DR   Reactome; R-DDI-3238698; WNT ligand biogenesis and trafficking.
DR   PRO; PR:Q54C24; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0140220; C:pathogen-containing vacuole; IDA:dictyBase.
DR   GO; GO:0030904; C:retromer complex; ISS:dictyBase.
DR   GO; GO:0030906; C:retromer, cargo-selective complex; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0045053; P:protein retention in Golgi apparatus; ISS:dictyBase.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:dictyBase.
DR   Gene3D; 1.25.40.660; -; 1.
DR   InterPro; IPR005378; Vps35.
DR   InterPro; IPR042491; Vps35_C.
DR   PANTHER; PTHR11099; PTHR11099; 1.
DR   Pfam; PF03635; Vps35; 1.
DR   PIRSF; PIRSF009375; Retromer_Vps35; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..781
FT                   /note="Vacuolar protein sorting-associated protein 35"
FT                   /id="PRO_0000328329"
SQ   SEQUENCE   781 AA;  89077 MW;  4606C1FD51598A62 CRC64;
     MMKKNKPTVA QTLSPEEEQA KFFEEAKNNV MIQGHHMKLS LDNSKLMDAL KYASNIINEL
     RTSLLSPKSY YALYLVAFDY LQYLNTYLYE EKHGKKMIEL YEVVQHAGNV LPRLYLLITV
     GSVYIKTKQA PAKDVLKDLI EMCRGVQHPT RGLFLRHYLS EVTKDKLPDI DSSVENGTVM
     DSIDFIIQNF TETNKLWVRM QHQAPTKDRE RRENERLELR LLVGKNLSRL AQLDGVDQKT
     YSEVVLPKVV EQIINCKDKI AQQYLMEILI QVFPDEFHLA TLDIILQTCA QLQSGVDVKT
     IIASLIDRLA NFATRNADLV PDNIKIFDIF FNNVKEIIQA RPNMELQDIL GLHVSLLNLT
     LKCYPTNKDN ANEVLGLCQS IIVNKAKEDI NKPTCVKQII QLLQIPLDVF KNVLVVLKLS
     NYQPLISCLS YNNRKKVSLD IVNNTINNST IIEEPEAVNN LLETIQTLIK DEQDQPDMDD
     IDKEDFQEEQ NKVASLIHLF DSEDPEKLFK IYIIARGHFG KGGPHRIRHT LVPLVFCSLR
     FIRNFKQQVD SGVISLDENK WIAIGSKIFT FVSETIKALA DIKLADLSFR LYLQALQTFD
     HCGLVSRVKE LAIKALLIFQ EDIADFKAQV MALQLLISTL NSLSIPNEEI YESLAAQTIK
     QASRLLLPQD QAKLISTCSH LFWVDNPSRQ YQNPDSVLQA LKKALSIISN ESSPGLGTFV
     DILNECLFYC DKETDAVPIQ FVSDLVELIR TTHVKEADPA LPYLQNTIKY IQSQNYKGIS
     I