ID   VPB12_MYCTU             Reviewed;          75 AA.
AC   P9WJ53; L0T7Q5; P71979; Q8VJY4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Putative antitoxin VapB12;
GN   Name=vapB12; OrderedLocusNames=Rv1721c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Putative antitoxin component of a possible type II toxin-
CC       antitoxin (TA) system. The cognate toxin is VapC12.
CC       {ECO:0000305|PubMed:15718296}.
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DR   EMBL; AL123456; CCP44487.1; -; Genomic_DNA.
DR   PIR; D70686; D70686.
DR   RefSeq; NP_216237.2; NC_000962.3.
DR   RefSeq; WP_003408469.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WJ53; -.
DR   SMR; P9WJ53; -.
DR   STRING; 83332.Rv1721c; -.
DR   PaxDb; P9WJ53; -.
DR   DNASU; 885182; -.
DR   GeneID; 885182; -.
DR   KEGG; mtu:Rv1721c; -.
DR   TubercuList; Rv1721c; -.
DR   eggNOG; ENOG502ZUJE; Bacteria.
DR   OMA; VMIQIRN; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..75
FT                   /note="Putative antitoxin VapB12"
FT                   /id="PRO_0000408059"
SQ   SEQUENCE   75 AA;  8226 MW;  0DC986EAC3552F8E CRC64;
     MSAMVQIRNV PDELLHELKA RAAAQRMSLS DFLLARLAEI AEEPALDDVL DRLAALPRRD
     LGASAAELVD EARSE