ID   VITRN_BOVIN             Reviewed;         652 AA.
AC   Q95LI2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Vitrin;
DE   Flags: Precursor;
GN   Name=VIT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=10830112; DOI=10.1042/bst0270832;
RA   Mayne R., Ren Z.-X., Liu J.G., Cook T., Carson M., Narayana S.;
RT   "VIT-1: the second member of a new branch of the von Willebrand factor A
RT   domain superfamily.";
RL   Biochem. Soc. Trans. 27:832-835(1999).
CC   -!- FUNCTION: Promotes matrix assembly and cell adhesiveness. Plays a role
CC       in spinal cord formation by regulating the proliferation and
CC       differentiation of neural stem cells. {ECO:0000250|UniProtKB:Q8VHI5}.
CC   -!- SUBUNIT: Binds dermatan sulfate and chondroitin sulfate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
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DR   EMBL; AF063832; AAL18262.2; -; mRNA.
DR   RefSeq; NP_776396.1; NM_173971.2.
DR   AlphaFoldDB; Q95LI2; -.
DR   SMR; Q95LI2; -.
DR   STRING; 9913.ENSBTAP00000034720; -.
DR   PaxDb; Q95LI2; -.
DR   PRIDE; Q95LI2; -.
DR   GeneID; 280957; -.
DR   KEGG; bta:280957; -.
DR   CTD; 5212; -.
DR   eggNOG; KOG1216; Eukaryota.
DR   InParanoid; Q95LI2; -.
DR   OrthoDB; 200139at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0021510; P:spinal cord development; ISS:UniProtKB.
DR   Gene3D; 2.170.130.20; -; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF03815; LCCL; 1.
DR   Pfam; PF00092; VWA; 2.
DR   SMART; SM00603; LCCL; 1.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF69848; SSF69848; 1.
DR   PROSITE; PS50820; LCCL; 1.
DR   PROSITE; PS50234; VWFA; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Neurogenesis;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..652
FT                   /note="Vitrin"
FT                   /id="PRO_0000248209"
FT   DOMAIN          40..133
FT                   /note="LCCL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DOMAIN          267..452
FT                   /note="VWFA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          469..638
FT                   /note="VWFA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          137..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        494
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        46..62
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        66..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
SQ   SEQUENCE   652 AA;  70873 MW;  3512421CA6987C51 CRC64;
     MGIVVLTMKA SVIEMFLVLL VTGIQSNQEM TKKMKRPKFT VPQISCDVRA GKITNVEFIV
     KCPPGCQDPR YHVYGADVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG
     VQSLSLPRWR ESFVVSEGKP QKGVTYPSSL TYSSSKSPAA KAGETARADQ SPPVPGTAAQ
     PVTVTQAPGT TAIEATHTTL PKPSPSAGST ASGLRPQPAG QRSKDLGEPA LWKPESVLLD
     AGFVPKEELS TQSLEPASQG DPSCKVDLSF LIDGSSSIGK RRFRIQKQFL TDVAQTLDIG
     PAGPLMGVVQ YGDNPATQFN LKTHMNSQDV KAAIEKISQR GGLSNAGRAI SFVTKNFFSK
     FNGNRGGAPN VAVVMVDGWP TDKVEEASRL ARESGVNIFF ITIEGASENE KQYMLEPNFA
     NKAVCRTNGF YSLTVQNWFS LHKTVQPLVK RVCDTDRLAC SKTCLNSADI GFVIDGSSSV
     GTSNFRTVLQ FVANLSREFE ISDMDTRIGA MQYTYEQRLE FGFDEYSTKS DVLNAIKRVG
     YWSGGTSTGA AIHYALEQLF KKSKPNKRKL MILITDGRSY DDIRIPAMLA HHKGVITYAI
     GVAWAAQDEL DIIATHPARD HAFFVDEFDN LYKVVPKVIQ NICTEFNSQP RN