ID   VE1_CRPVW               Reviewed;         178 AA.
AC   P51894; Q85059;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   23-FEB-2022, entry version 67.
DE   RecName: Full=Replication protein E1;
DE            EC=3.6.4.12;
DE   AltName: Full=ATP-dependent helicase E1;
DE   Flags: Fragments;
GN   Name=E1;
OS   Cottontail rabbit papillomavirus (strain Washington B) (CRPV)
OS   (Papillomavirus sylvilagi).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Kappapapillomavirus.
OX   NCBI_TaxID=31554;
OH   NCBI_TaxID=9989; Rodentia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wu X., Xiao W., Brandsma J.;
RL   Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent DNA helicase required for initiation of viral
CC       DNA replication. It forms a complex with the viral E2 protein. The E1-
CC       E2 complex binds to the replication origin which contains binding sites
CC       for both proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; U09467; AAB60539.1; -; Genomic_DNA.
DR   EMBL; U09495; AAB60540.2; -; Genomic_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR001177; DNA_helicase_E1_C_Papillomavir.
DR   InterPro; IPR014000; DNA_helicase_E1_N_Papillomavir.
DR   Pfam; PF00519; PPV_E1_C; 1.
DR   Pfam; PF00524; PPV_E1_N; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Early protein; Helicase;
KW   Host nucleus; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..>178
FT                   /note="Replication protein E1"
FT                   /id="PRO_0000133167"
FT   NON_CONS        93..94
FT                   /evidence="ECO:0000305"
FT   NON_TER         178
SQ   SEQUENCE   178 AA;  19607 MW;  CF487ED0385F4EC6 CRC64;
     MAEGTDPLDD CGGFLDTEAD CLDCDNLEED LTELFDADTV SSLLDDTDQV QGNSLELFQH
     HEATETLKSI EHLKRKYVDS PDKSLGIDNS VNAESLQVES GFGSQQSVSD TPVTDILNAN
     TARVKHLLLF RQAHSVSFSE LTRTFQSDKT MSWDWVGGLA DIHASVLESL QTSLRSHC