ID   VB04_VARV               Reviewed;         558 AA.
AC   P0DST0; P33823;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 11.
DE   RecName: Full=Ankyrin repeat protein B4;
GN   ORFNames=B4R, B5R, B6R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60914.1; -; Genomic_DNA.
DR   PIR; T28604; T28604.
DR   RefSeq; NP_042218.1; NC_001611.1.
DR   SMR; P0DST0; -.
DR   GeneID; 1486562; -.
DR   KEGG; vg:1486562; -.
DR   Proteomes; UP000119805; Genome.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat; Repeat.
FT   CHAIN           1..558
FT                   /note="Ankyrin repeat protein B4"
FT                   /id="PRO_0000448100"
FT   REPEAT          65..95
FT                   /note="ANK 1"
FT   REPEAT          169..205
FT                   /note="ANK 2"
FT   REPEAT          209..239
FT                   /note="ANK 3"
FT   REPEAT          243..272
FT                   /note="ANK 4"
FT   REPEAT          276..304
FT                   /note="ANK 5"
FT   REPEAT          339..368
FT                   /note="ANK 6"
FT   REPEAT          372..401
FT                   /note="ANK 7"
SQ   SEQUENCE   558 AA;  65173 MW;  B26983D43D0836B8 CRC64;
     MDFFKKEILD WSIYLSLHYI AHACSNSSTS HIIQEYNLIR TYKKVDKTIV DFLSRWPNLF
     HILEYGENIL HIYSMDDANT NIIIFFLDNV LNINKNGSFI HNLGLSSSIN IKEYVYQLVN
     NDHLDNGIRL MLENGRRTRH FLSYILDTVN IYICILINHG FYIDAVDSYG CTLLHRCIYH
     YKKSESESYN ELIKILLNNG SDVDKKDTHG NTPFILLCKH DIDNVELFEI CLENANIDSV
     DFNGYTPLHY VSCRNKYDFV KSLISKGANV NTRNRFGTTP FYCGIIHGIS LIKLYLESDT
     ELEIDNEHIV RHLIIFDAVE SLDYLLFRGV IDINYRTIYN ETSIYDAVSY NAYNMLVYLL
     NRNGDFETIT TSGCTCISKA VANNNKIIME VLLSKQPSLK IMILSIIAIT KHKQHNTNLL
     KMCIKYTACM TDYDTLIDVQ SLQQYKWYIL KCFDEIDIMK RCYIKNKTVF QLVFCTKDIN
     TLMRYGRHPS FVKYTSLDVY GSRVRNIIAS IRYRQRLISL LSKKLDVGDK WACFPNEIKY
     KILENFNDNE LSTYLKIL