ID   UXUA_ENT38              Reviewed;         396 AA.
AC   A4WCK2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=Ent638_2767;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CP000653; ABP61432.1; -; Genomic_DNA.
DR   RefSeq; WP_015959765.1; NC_009436.1.
DR   AlphaFoldDB; A4WCK2; -.
DR   SMR; A4WCK2; -.
DR   STRING; 399742.Ent638_2767; -.
DR   PRIDE; A4WCK2; -.
DR   EnsemblBacteria; ABP61432; ABP61432; Ent638_2767.
DR   KEGG; ent:Ent638_2767; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   OrthoDB; 907794at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..396
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_1000057702"
SQ   SEQUENCE   396 AA;  44838 MW;  189FB6CC55E4C1D2 CRC64;
     MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGEVW PVEEIKKRQA VLADKGLTWS
     VVESIPVHED IKTHSGQFET WIANYQQSIR NLATCGIDTV CYNFMPILDW TRTDLEYQMP
     DGSRALRFDQ IAFAAFELHI LKRPSAEADY SAEEQQQALK WFEDASDADI EKLTRNIIAG
     LPGAEEGYTL DQFRARLAEY GDIDKNQLRE NMAYFLRAIV PVAEACGLRL AVHPDDPPRP
     ILGLPRIVST IEDMQWLKET VDSINNGFTM CTGSYGVRED NDLVKMIEAF GDRIHFTHLR
     ATCRENNPKT FHEAAHLGGD VNMVAVVDAI LSEEQRRKHA GDMRPIPFRP DHGHQMLDDL
     RKKTNPGYSA IGRLKGMAEV RGVELALKML KYPELL