ID   UVRC_METHJ              Reviewed;         520 AA.
AC   Q2FPC6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mhun_1161;
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1;
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000254; ABD40909.1; -; Genomic_DNA.
DR   RefSeq; WP_011448187.1; NC_007796.1.
DR   AlphaFoldDB; Q2FPC6; -.
DR   SMR; Q2FPC6; -.
DR   STRING; 323259.Mhun_1161; -.
DR   EnsemblBacteria; ABD40909; ABD40909; Mhun_1161.
DR   GeneID; 3922969; -.
DR   KEGG; mhu:Mhun_1161; -.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_2_2; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 5341at2157; -.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..520
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264987"
FT   DOMAIN          11..89
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          195..230
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   520 AA;  59291 MW;  9CAD69921DE36882 CRC64;
     MVSIDLTTIP EEPGCYQFKD ETGTILYVGK AKNLKKRVSS YFQKKSITPR IDILVSLIRD
     IDVIVTSSEV EALILENNLI KKYQPKYNID LKDAKSYAFI QISNDPFPRI GIARDRTVKK
     TGTLYGPFVS AAERDQILKF VKQTFHLRTC KKMTKRACLR SHLGTCAAPC TGKISEPEYQ
     YLVKSADYLL KGKSQDLIYD LRKEMETFAA AEEYEKALVI RDRIAAIENL SERQYVQRQK
     KSDEHIINYL VSGDTVYLIL FHVERGSLTS KEEFVFPETE DFLDEFILQY YSSTKPPNEL
     ILPSLPGSGM EEYLTHIRGS HVTLTIPKQG EKKHLLDLAY KNLEVSFFTG KMRLAELGEA
     LHMDTAPEVI ECFDISHLRG TGTVASMVSF RDGKPDKRNY RRYKINSAGP SDDYAAMAEV
     VKRRYSRLLR EKSPMPDLIV VDGGPGQLKS AHAILEELSL PIPIISIAKR EEEIYIPGRN
     TPLSIQKKSP ASLLIQEIRD EAHRFAITYQ KKLRQKSIKE