ID   UVRC_ARTS2              Reviewed;         669 AA.
AC   A0JWP2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Arth_2082;
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24;
RX   PubMed=24501649; DOI=10.4056/sigs.4438185;
RA   Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA   Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT   "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL   Stand. Genomic Sci. 9:106-116(2013).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000454; ABK03462.1; -; Genomic_DNA.
DR   RefSeq; WP_011691928.1; NC_008541.1.
DR   AlphaFoldDB; A0JWP2; -.
DR   SMR; A0JWP2; -.
DR   STRING; 290399.Arth_2082; -.
DR   EnsemblBacteria; ABK03462; ABK03462; Arth_2082.
DR   KEGG; art:Arth_2082; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..669
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077753"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   669 AA;  73440 MW;  8C55B4B6E75312AD CRC64;
     MADPASYRPQ TGEIPTNPGV YRFRDPHGRV IYVGKAKSLR SRLNSYFANP GGLLPKTYAM
     VHAASSVEWT VVASELESLQ LEYTWIKEFK PRFNVVFRDD KTYPYLAVTM GEKFPRVQVL
     RGERRKGTRY FGPYTAGAIR ETMDTLLRVF PVRSCSPGVL KRAQASGRPC LLGYIDKCAA
     PCVGRVTPEE HRALAEDFCS FMGGEAKRFI GRLEKDMAAA VAELDYERAA RVRDDIIALR
     KVFERNAVVL AEDTDADVFA LHEDELEAAV QVFHVRGGRV RGQRGWVVEK VEDFTTPDLV
     EHLLQQVYGE EGETQGRLPR EVLVPEEPSN AAELAQWLAG LRGAKVDIRV PRRGDKAALM
     STVRENAEHA LKLHKSRRAG DLTNRSLALQ ELQEALDLPV ALLRIECFDI SHVQGTNVVA
     SMVVVEDGLP KKSDYRKFSI TGAAAVDDTA AMHDVLTRRF RNYLQEKAAQ AEAAQLPGHQ
     AALEAMAVAS MQDTTTPAPR AKFAYPPNLV VVDGGKPQVN AAARALAELG IDDVYVVGLA
     KRLEEVWLPD SDFPVILPRT SEGLYLLQRI RDEAHRFAIT FHRQKRGKAM TVSALDSVPG
     LGEAKRKALL AQFGSVKSIR TASAAELATA KGIGPSLADA IVSHFSNGAA ASGAEAPSIN
     MTTGEIIET