UVRA_BRADU
ID UVRA_BRADU Reviewed; 991 AA.
AC Q89L46;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=blr4702;
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium.
OX NCBI_TaxID=224911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000040; BAC49967.1; -; Genomic_DNA.
DR RefSeq; NP_771342.1; NC_004463.1.
DR RefSeq; WP_011087470.1; NZ_CP011360.1.
DR AlphaFoldDB; Q89L46; -.
DR SMR; Q89L46; -.
DR STRING; 224911.27352966; -.
DR EnsemblBacteria; BAC49967; BAC49967; BAC49967.
DR GeneID; 64024460; -.
DR KEGG; bja:blr4702; -.
DR PATRIC; fig|224911.44.peg.4531; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_5; -.
DR InParanoid; Q89L46; -.
DR OMA; PFEGIIP; -.
DR PhylomeDB; Q89L46; -.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 3.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..991
FT /note="UvrABC system protein A"
FT /id="PRO_0000093037"
FT DOMAIN 345..624
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 644..972
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 775..801
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 48..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 676..683
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 991 AA; 109541 MW; 0C16B04DE43FF1FA CRC64;
MDEVIKAKRQ QQNAGSSLRA ITIRGAREHN LKNIDVEIPR DKLVVFTGLS GSGKSSLAFD
TIYAEGQRRY VESLSAYARQ FLEMMQKPDV DQIDGLSPAI SIEQKTTSKN PRSTVGTVTE
IYDYMRLLWA RVGVPYSPAT GLPIESQTVS QMVDRVLALP EGTRLYLLAP VVRGRKGEYR
KELAEWLKKG FQRVKIDGTF HELAEAPTLD KKFPHDIDVV VDRIVVRADI GQRLAESFET
ALKLAEGLAV VEFADAPAAA PAEEKKKTAK IHDKSGPERI LFSEKFACPV SGFTIPEIEP
RLFSFNNPYG ACPACGGLGV EQHVDEDLVI PDKELAIGKG AIAPWAKSSS PYYVQTLTAL
GKHYKFTLTT KWKDLPKKTR DAILHGSGED EIKFSYEDGV RSYDTKKPFE GVITNINRRY
RETESEWARE ELAKYFHDVP CGACNGFRLK PEALCVKVGT KHIGEISELS VKKAGEWFET
VPEALNKQQN EIAGRILKEI RERLTFLLDV GLNYLTLSRS SGTLSGGESQ RIRLASQIGS
GLTGVLYVLD EPSIGLHQRD NARLLDTLKR LRDLGNTVVV VEHDEDAIRL ADYVLDIGPG
AGMHGGHIVA EGTPAEIMRN PKSLTGKYLT GELEVEVPER RPPNHRRTIK VVNARGNNLK
NVTAEIPLGL FTCVTGVSGG GKSTLLIDTL YRAIARKLNN ASEGAAPHDR IEGLEHIDKI
IDIDQSPIGR TPRSNPATYT GAFTPIREWF AGLPEAKARG YEPGRFSFNV KGGRCEACQG
DGVIKIEMHF LPDVYVTCDV CKGKRYNRET LEVLFKGKSI ADVLDMTVEE AADFFKAVPR
VRETFQTLHR VGLDYIHVGQ QATTLSGGEA QRVKLAKELS KRATGRTLYI LDEPTTGLHF
HDVKKLLEVL HELVAQGNTV VVIEHNLEVI KTADWVIDLG PEGGDGGGEI VAWGPPEDIA
KAPRSYTGKF LEPVLKKARK PKRRSTSEAA E
