ID   UVRA_AGRFC              Reviewed;         973 AA.
AC   Q8UF86;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=Atu1513;
GN   ORFNames=AGR_C_2790;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC       Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR   EMBL; AE007869; AAK87304.2; -; Genomic_DNA.
DR   PIR; AH2762; AH2762.
DR   PIR; G97543; G97543.
DR   RefSeq; NP_354519.2; NC_003062.2.
DR   RefSeq; WP_010971680.1; NC_003062.2.
DR   AlphaFoldDB; Q8UF86; -.
DR   SMR; Q8UF86; -.
DR   STRING; 176299.Atu1513; -.
DR   PRIDE; Q8UF86; -.
DR   EnsemblBacteria; AAK87304; AAK87304; Atu1513.
DR   KEGG; atu:Atu1513; -.
DR   PATRIC; fig|176299.10.peg.1539; -.
DR   eggNOG; COG0178; Bacteria.
DR   HOGENOM; CLU_001370_2_1_5; -.
DR   OMA; PFEGIIP; -.
DR   PhylomeDB; Q8UF86; -.
DR   BioCyc; AGRO:ATU1513-MON; -.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW   Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW   Repeat; SOS response; Zinc; Zinc-finger.
FT   CHAIN           1..973
FT                   /note="UvrABC system protein A"
FT                   /id="PRO_0000093032"
FT   DOMAIN          331..609
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   DOMAIN          629..958
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         761..787
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ   SEQUENCE   973 AA;  107032 MW;  B4F4009B9445C7B9 CRC64;
     MSELKTISIR GAREHNLKGI DLDLPRNKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL
     SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY MRLLFARVGV
     PYSPATGLPI ESQTVSQMVD RILAFEEGTR LYILAPIVRG RKGEYKKELA ELMKKGFQRV
     KVDGQFYEIA DVPALDKKYK HDIDVVVDRA VVRPDMAARL ADSLETCLKL ADGLAIAEFA
     DKPLPPEDTA AGGSANKSLN ETHERVLFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPS
     CDGLGSQQKV DENLIVPEPA RTLRDGAIAP WAKSSSPYYN QTLEALGKAF GFKLSSKWTD
     LSKEAQHAIL QGTDDKIEFN YQDGARSYKT VKNFEGIVPN LERRWKETDS AWAREEIERY
     MSAAPCPACA GYRLKPEALA VKINKLHIGE VTQMSIRKAR DWFEVLPENL NAKQNEIAVR
     ILKEIRERLR FLNDVGLDYL SLSRNSGTLS GGESQRIRLA SQIGSGLTGV LYVLDEPSIG
     LHQRDNARLL ETLKHLRDIG NTVIVVEHDE DAILTADYVV DIGPAAGIHG GQVIAEGTPQ
     DVMANPKSLT GKYLSGELGV AVPAERRKPK KGREIKVFGA RGNNLQNVTA AVPLGVFTAV
     TGVSGGGKST FLIETLYKSA ARRVMGAREI PAEHDRIDGF EFIDKVIDID QSPIGRTPRS
     NPATYTGAFT PIRDWFAGLP EAKARGYAPG RFSFNVKGGR CEACQGDGVI KIEMHFLPDV
     YVTCDVCHGK RYNRETLDVT FKGKSIADVL DMTVEEGVEF FAAVPAVRDK LQSLFDVGLG
     YIKVGQQANT LSGGEAQRVK LAKELSKRST GRTLYILDEP TTGLHFHDVN KLLEMLHALV
     EQGNSVVVIE HNLEVIKTAD WIIDIGPEGG TGGGEVVATG TPEDIVKVER SYTGHFLKEL
     LDRRPAGKRE AAE