ID   UTP25_EMENI             Reviewed;         702 AA.
AC   Q5BDM6; C8VRX5;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=AN1354.2;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA65537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000018; EAA65537.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001308; CBF87659.1; -; Genomic_DNA.
DR   RefSeq; XP_658958.1; XM_653866.1.
DR   AlphaFoldDB; Q5BDM6; -.
DR   STRING; 162425.CADANIAP00001257; -.
DR   EnsemblFungi; CBF87659; CBF87659; ANIA_01354.
DR   EnsemblFungi; EAA65537; EAA65537; AN1354.2.
DR   GeneID; 2877134; -.
DR   KEGG; ani:AN1354.2; -.
DR   VEuPathDB; FungiDB:AN1354; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q5BDM6; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..702
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408117"
FT   REGION          1..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..138
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   702 AA;  79546 MW;  7BAB4025E2F5A27B CRC64;
     MPFRGGGQKG RGRGSVKRKG PGFTAARVDE VEYAEGLDDD VLSDSDESDQ QSGQPYNELL
     QLLQAKTDSK GPARKKRKTS HQNKEGTEEA ENVAEMTAVE EGEETLDAEL QQQEPDEEGD
     LEDGDVDAQE DSDDEESGNE PFESHFSSPD ESELSQKIKA ASENKWKNAK KELPGGLKIW
     RAIPDCGQDD VPLLAAMKSM SSVKVKRKLK SAVTERIPSL SGNVQQVSPY IFDYQDVLYG
     ARTTSESADM RDMLAVHATN HVLKTRDRVL KNNARVAKEQ DGDLELRDQG FTRPKVLYLL
     PTRQACVRVV ESITRFFQPE QQENKKRFID AFSASDDPSW EDKPQDFREL FGGNDDDMFR
     IGLKFTRKTL KFFTQFYTSD LILASPLGLR TIMDQADVKK RDHDFLSSVE VVIVDHTDAL
     LMQNWDHVSY ILKHLNLQPK EAHGCDFSRV RTWYLDNNAR YVRQLILLSS FITPEINSVF
     STHMHNVFGK VKLNPIYNGA IAELPLPVPV KQTFTRFDCL SPTKDPDARF KHFTTTILST
     LVRNITTSRN RASAGGTLIF IPSYLDFVRL RNYFATSQQT TNVSFGAISE YTEPREISRA
     RSYFMTGRQS VLLYTERLHH FRRFRIRGVK RIIMYGMPDN PIFWGEIVGF LGLDPAGVVE
     AAEGGVRALF SKYDALKLER IVGTKRVGNM LREKGGDTFT FM