UT14B_MOUSE
ID UT14B_MOUSE Reviewed; 756 AA.
AC Q6EJB6; Q6EJB5; Q8BL60;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=U3 small nucleolar RNA-associated protein 14 homolog B;
DE AltName: Full=Juvenile spermatogonial depletion protein;
GN Name=Utp14b; Synonyms=Jsd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GENOMIC
RP ORGANIZATION, AND CHROMOSOMAL LOCATION.
RX PubMed=15258580; DOI=10.1038/ng1390;
RA Bradley J., Baltus A., Skaletsky H., Royce-Tolland M., Dewar K., Page D.C.;
RT "An X-to-autosome retrogene is required for spermatogenesis in mice.";
RL Nat. Genet. 36:872-876(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 512-756.
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, GENOMIC ORGANIZATION, AND CHROMOSOMAL
RP LOCATION.
RX PubMed=15289605; DOI=10.1073/pnas.0401130101;
RA Rohozinski J., Bishop C.E.;
RT "The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a
RT mutation in the X-derived retrogene, mUtp14b.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11695-11700(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for spermatogenesis. May be required specifically
CC for ribosome biogenesis and hence protein synthesis during male
CC meiosis. {ECO:0000269|PubMed:15258580, ECO:0000269|PubMed:15289605}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in germ cells of the
CC testis; weakly expressed in brain. {ECO:0000269|PubMed:15258580,
CC ECO:0000269|PubMed:15289605}.
CC -!- MISCELLANEOUS: Apparently encoded by an autosomal retrotransposed copy
CC of the X-linked gene Utp14a. Evolution of autosomal retrogenes from X-
CC linked progenitors compensates for X-chromosome silencing during male
CC meiosis.
CC -!- SIMILARITY: Belongs to the UTP14 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ87009.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY316161; AAQ87009.1; ALT_INIT; mRNA.
DR EMBL; AY316162; AAQ87010.1; -; mRNA.
DR EMBL; AK046254; BAC32659.1; -; mRNA.
DR RefSeq; NP_001001981.2; NM_001001981.3.
DR AlphaFoldDB; Q6EJB6; -.
DR SMR; Q6EJB6; -.
DR BioGRID; 228836; 12.
DR STRING; 10090.ENSMUSP00000052149; -.
DR iPTMnet; Q6EJB6; -.
DR PhosphoSitePlus; Q6EJB6; -.
DR EPD; Q6EJB6; -.
DR MaxQB; Q6EJB6; -.
DR PaxDb; Q6EJB6; -.
DR PeptideAtlas; Q6EJB6; -.
DR PRIDE; Q6EJB6; -.
DR ProteomicsDB; 297945; -.
DR DNASU; 195434; -.
DR GeneID; 195434; -.
DR KEGG; mmu:195434; -.
DR CTD; 195434; -.
DR MGI; MGI:2445092; Utp14b.
DR eggNOG; KOG2172; Eukaryota.
DR InParanoid; Q6EJB6; -.
DR PhylomeDB; Q6EJB6; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 195434; 3 hits in 75 CRISPR screens.
DR PRO; PR:Q6EJB6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6EJB6; protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR InterPro; IPR006709; SSU_processome_Utp14.
DR PANTHER; PTHR14150; PTHR14150; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Differentiation; Meiosis; Nucleus;
KW Phosphoprotein; Reference proteome; Ribosome biogenesis; Spermatogenesis.
FT CHAIN 1..756
FT /note="U3 small nucleolar RNA-associated protein 14 homolog
FT B"
FT /id="PRO_0000065735"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..244
FT /evidence="ECO:0000255"
FT COILED 316..345
FT /evidence="ECO:0000255"
FT COILED 449..476
FT /evidence="ECO:0000255"
FT COMPBIAS 435..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q640M1"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q640M1"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q640M1"
FT MOD_RES 554
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 731
FT /note="L -> F (in Ref. 2; BAC32659)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 756 AA; 85928 MW; 182108231EC70C02 CRC64;
MNMARNVTDL LALSQQEELV DLPENYPLST SEDEGDSDGE GKRQKLLEAV SSLGRKNKWK
LAERSEASRM VSEFNVTSEG SGEKLVLSDL LGSATALSSV AAVKKQLHRV KSKTLTPPLN
KEEADRALRE AAFSKTSQML SRWDPVVLKN RQAEQLIFPM EKEPPAVAPI EHVFTDWKVR
TPLEQEVFNL LHKNKQPVTD PLLTPVETAS IRAMSLEEAK IRRAELQRMR ALQSYYEARA
RREKRIKSKK YHRALKKGKA KKALKEFEEL WKDCPNAALQ ELEKMEKARM TERMSLKHQG
SGKWAKSKAI MAKYDPEARK AMQEQLAKNR ELTQKLQVVS ESEEEDGCTE EGIVSVSHGM
DDLQMNADGV NPWMLSSCNS NAKRGEIKTD PEQMPEFVAH VSSESEGDER PVAEELVLKE
RSFQERVDPN NAKLMDGQET EDSDSQEVLQ KLNKESHQSD NQKVSSEENV LHIQREDLAS
EKLLVLQRLE RAHVLEQQGE LSKEEHYPKK GLSRPLLKGD WKEMKPLTNP DASGGKKKKE
QMIDLRNLLT ANSSPVRSLA VPTIQQLEDE VETDHKQLIR EAFAGDDVIR EFLKEKREAI
ETNKPKDLDL SLPGWGEWVG MGLKPSAKKR RRFLIKAPES SPRKDKNLPN VIISEKRNIH
AAAHQVRALP HPFTHQQQFE RTIQNPIGYM WNTQRTFQKL TVPKVGTKLG HIIKPIKAEN
VGYCSSTRSD LSILQSSQKC LSRKQQKQLK KLSSAD
