ID   USPE_SHIFL              Reviewed;         316 AA.
AC   P0AAC3; P03807; P77421;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Universal stress protein E;
GN   Name=uspE; OrderedLocusNames=SF1837, S1433;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AE005674; AAN43399.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16835.1; -; Genomic_DNA.
DR   RefSeq; NP_707692.2; NC_004337.2.
DR   RefSeq; WP_001262123.1; NZ_WPGW01000191.1.
DR   AlphaFoldDB; P0AAC3; -.
DR   SMR; P0AAC3; -.
DR   STRING; 198214.SF1837; -.
DR   EnsemblBacteria; AAN43399; AAN43399; SF1837.
DR   EnsemblBacteria; AAP16835; AAP16835; S1433.
DR   GeneID; 1025007; -.
DR   GeneID; 66674839; -.
DR   KEGG; sfl:SF1837; -.
DR   KEGG; sfx:S1433; -.
DR   PATRIC; fig|198214.7.peg.2185; -.
DR   HOGENOM; CLU_049301_1_2_6; -.
DR   OMA; MAKYQNM; -.
DR   OrthoDB; 2040681at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..316
FT                   /note="Universal stress protein E"
FT                   /id="PRO_0000147424"
SQ   SEQUENCE   316 AA;  35707 MW;  F5F416848D452378 CRC64;
     MAMYQNMLVV IDPNQDDQPA LRRAVYLHQR IGGKIKAFLP IYDFSYEMTT LLSPDERTAM
     RQGVISQRTA WIHEQAKYYL NAGVPIEIKV VWHNRPFEAI IQEVISGGHD LVLKMAHQHD
     RLEAVIFTPT DWHLLRKCPS PVWMVKDQPW PEGGKALVAV NLASEEPYHN ALNEKLVKET
     IELAEQVNHT EVHLVGAYPV TPINIAIELP EFDPSVYNDA IRGQHLLAMK ALRQKFGINE
     NMTHVEKGLP EEVIPDLAEH LQAGIVVLGT VGRTGISAAF LGNTAEQVID HLRCDLLVIK
     PDQYQTPVEL DDEEDD