ID   US8A_HHV11              Reviewed;         159 AA.
AC   O09802; B9VQK3; Q09I68;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=Protein US8.5;
GN   ORFNames=US8.5;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2984429; DOI=10.1016/0022-2836(85)90320-1;
RA   McGeoch D.J., Dolan A., Donald S., Rixon F.J.;
RT   "Sequence determination and genetic content of the short unique region in
RT   the genome of herpes simplex virus type 1.";
RL   J. Mol. Biol. 181:1-13(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RX   PubMed=8572943; DOI=10.1007/bf01323242;
RA   Georgopoulou U., Kakkanas A., Miriagou V., Michaelidou A., Mavromara P.;
RT   "Characterization of the US8.5 protein of herpes simplex virus.";
RL   Arch. Virol. 140:2227-2241(1995).
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:8572943}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:8572943}.
CC   -!- SIMILARITY: Belongs to the HHV-1 US8.5 protein family. {ECO:0000305}.
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DR   EMBL; X14112; CAA32273.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63527.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62298.1; -; Genomic_DNA.
DR   RefSeq; YP_009137144.1; NC_001806.2.
DR   iPTMnet; O09802; -.
DR   PRIDE; O09802; -.
DR   GeneID; 2703450; -.
DR   KEGG; vg:2703450; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR017377; Herpes_US8A.
DR   PIRSF; PIRSF038076; US8A; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..159
FT                   /note="Protein US8.5"
FT                   /id="PRO_0000116143"
FT   REGION          27..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..51
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         82
FT                   /note="E -> K (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         109
FT                   /note="T -> M (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         122
FT                   /note="A -> T (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         149
FT                   /note="A -> V (in strain: Nonneuroinvasive mutant HF10)"
SQ   SEQUENCE   159 AA;  16802 MW;  5C2E42C368A19006 CRC64;
     MDPALRSYHQ RLRLYTPVAM GINLAASSQP LDPEGPIAVT PRPPIRPSSG KAPHPEAPRR
     SPNWATAGEV DVGDELIAIS DERGPPRHDR PPLATSTAPS PHPRPPGYTA VVSPMALQAV
     DAPSLFVAWL AARWLRGASG LGAVLCGIAW YVTSIARGA