ID   UREE_PROMH              Reviewed;         161 AA.
AC   P17090; B4EXN6;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Urease accessory protein UreE {ECO:0000255|HAMAP-Rule:MF_00822};
GN   Name=ureE {ECO:0000255|HAMAP-Rule:MF_00822}; OrderedLocusNames=PMI3686;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2687233; DOI=10.1128/jb.171.12.6414-6422.1989;
RA   Jones B.D., Mobley H.L.T.;
RT   "Proteus mirabilis urease: nucleotide sequence determination and comparison
RT   with jack bean urease.";
RL   J. Bacteriol. 171:6414-6422(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
RN   [3]
RP   UREASE AS A VIRULENCE FACTOR.
RX   PubMed=2180821; DOI=10.1128/iai.58.4.1120-1123.1990;
RA   Jones B.D., Lockatell C.V., Johnson D.E., Warren J.W., Mobley H.L.T.;
RT   "Construction of a urease-negative mutant of Proteus mirabilis: analysis of
RT   virulence in a mouse model of ascending urinary tract infection.";
RL   Infect. Immun. 58:1120-1123(1990).
RN   [4]
RP   PROBABLE OPERON STRUCTURE, AND FUNCTION.
RX   PubMed=7559355; DOI=10.1128/jb.177.19.5653-5660.1995;
RA   Island M.D., Mobley H.L.T.;
RT   "Proteus mirabilis urease: operon fusion and linker insertion analysis of
RT   ure gene organization, regulation, and function.";
RL   J. Bacteriol. 177:5653-5660(1995).
CC   -!- FUNCTION: Involved in urease metallocenter assembly. Binds nickel.
CC       Probably functions as a nickel donor during metallocenter assembly. It
CC       is not essential for urease activity. {ECO:0000255|HAMAP-Rule:MF_00822,
CC       ECO:0000269|PubMed:7559355}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00822}.
CC   -!- SIMILARITY: Belongs to the UreE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00822}.
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DR   EMBL; M31834; AAA25670.1; -; Genomic_DNA.
DR   EMBL; AM942759; CAR47186.1; -; Genomic_DNA.
DR   PIR; E43719; E43719.
DR   RefSeq; WP_004245261.1; NC_010554.1.
DR   AlphaFoldDB; P17090; -.
DR   SMR; P17090; -.
DR   STRING; 529507.PMI3686; -.
DR   EnsemblBacteria; CAR47186; CAR47186; PMI3686.
DR   GeneID; 6800328; -.
DR   KEGG; pmr:PMI3686; -.
DR   eggNOG; COG2371; Bacteria.
DR   HOGENOM; CLU_093757_2_0_6; -.
DR   OMA; AYDARCK; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR   GO; GO:0019627; P:urea metabolic process; IEA:InterPro.
DR   CDD; cd00571; UreE; 1.
DR   HAMAP; MF_00822; UreE; 1.
DR   InterPro; IPR012406; UreE.
DR   InterPro; IPR007864; UreE_C_dom.
DR   InterPro; IPR004029; UreE_N.
DR   InterPro; IPR036118; UreE_N_sf.
DR   Pfam; PF05194; UreE_C; 1.
DR   Pfam; PF02814; UreE_N; 1.
DR   PIRSF; PIRSF036402; Ureas_acces_UreE; 1.
DR   SMART; SM00988; UreE_N; 1.
DR   SUPFAM; SSF69287; SSF69287; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel; Nickel insertion; Reference proteome;
KW   Virulence.
FT   CHAIN           1..161
FT                   /note="Urease accessory protein UreE"
FT                   /id="PRO_0000067637"
SQ   SEQUENCE   161 AA;  17887 MW;  0126E60CF1B22BBF CRC64;
     MKKFTQIIDQ QKALELTSTE KPKLTLCLTM DERTKSRLKV ALSDGQEAGL FLPRGTVLKE
     GDILLSEEGD VVTIEAAKEQ VSTVYSDDPL LLARVCYHLG NRHVPLQIEA GWCRYFHDHV
     LDDMARGLGA TVVVGLEKYQ PEPGAYGGSS GGHHHHHDHH H