ID   UREE_HELHP              Reviewed;         174 AA.
AC   Q7VJ36; Q93PJ2;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Urease accessory protein UreE {ECO:0000255|HAMAP-Rule:MF_00822};
GN   Name=ureE {ECO:0000255|HAMAP-Rule:MF_00822}; OrderedLocusNames=HH_0410;
OS   Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=235279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MU94-1;
RX   PubMed=11500473; DOI=10.1128/iai.69.9.5914-5920.2001;
RA   Beckwith C.S., McGee D.J., Mobley H.L.T., Riley L.K.;
RT   "Cloning, expression, and catalytic activity of Helicobacter hepaticus
RT   urease.";
RL   Infect. Immun. 69:5914-5920(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51449 / 3B1;
RX   PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA   Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA   Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA   Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA   Shen Z., Weber J., Frosch M., Fox J.G.;
RT   "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT   hepaticus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC   -!- FUNCTION: Involved in urease metallocenter assembly. Binds nickel.
CC       Probably functions as a nickel donor during metallocenter assembly.
CC       {ECO:0000255|HAMAP-Rule:MF_00822}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00822}.
CC   -!- SIMILARITY: Belongs to the UreE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00822}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP77007.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF332656; AAK69201.1; -; Genomic_DNA.
DR   EMBL; AE017125; AAP77007.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011115252.1; NC_004917.1.
DR   AlphaFoldDB; Q7VJ36; -.
DR   SMR; Q7VJ36; -.
DR   STRING; 235279.HH_0410; -.
DR   EnsemblBacteria; AAP77007; AAP77007; HH_0410.
DR   KEGG; hhe:HH_0410; -.
DR   eggNOG; COG2371; Bacteria.
DR   HOGENOM; CLU_093757_3_0_7; -.
DR   OMA; YVDLEWF; -.
DR   OrthoDB; 1663151at2; -.
DR   Proteomes; UP000002495; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR   GO; GO:0019627; P:urea metabolic process; IEA:InterPro.
DR   CDD; cd00571; UreE; 1.
DR   HAMAP; MF_00822; UreE; 1.
DR   InterPro; IPR012406; UreE.
DR   InterPro; IPR007864; UreE_C_dom.
DR   InterPro; IPR004029; UreE_N.
DR   InterPro; IPR036118; UreE_N_sf.
DR   Pfam; PF05194; UreE_C; 1.
DR   Pfam; PF02814; UreE_N; 1.
DR   SMART; SM00988; UreE_N; 1.
DR   SUPFAM; SSF69287; SSF69287; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel; Nickel insertion; Reference proteome.
FT   CHAIN           1..174
FT                   /note="Urease accessory protein UreE"
FT                   /id="PRO_0000223418"
SQ   SEQUENCE   174 AA;  20173 MW;  DDAB599130AABF79 CRC64;
     MRVEHIIGNI KDIDATHLDI DEVQIAWYDT KKKIARLNSQ NGQVIAMKLA QAPKYGLNNG
     DILFLDEHKI IIISILPTWV LCMKPTHWHT MARLCYEIGN LHIPLFYNKD TMKLQAPFEQ
     PLQRILEKQS IAFEKKWCVL DSKDRINITY PIASEPKLIQ SPHFSIKITQ KGLN