CAD15_MOUSE
ID CAD15_MOUSE Reviewed; 784 AA.
AC P33146; B2RXU1; Q9QYZ7;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Cadherin-15;
DE AltName: Full=Cadherin-14;
DE AltName: Full=Muscle cadherin;
DE Short=M-cadherin;
DE Flags: Precursor;
GN Name=Cdh15; Synonyms=Cdh14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C3H/HeJ; TISSUE=Muscle;
RA Link D.;
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Muscle;
RX PubMed=1840697; DOI=10.1073/pnas.88.18.8024;
RA Donalies M., Cramer M., Ringwald M., Starzinski-Powitz A.;
RT "Expression of M-cadherin, a member of the cadherin multigene family,
RT correlates with differentiation of skeletal muscle cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:8024-8028(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 539-617.
RX PubMed=10610704; DOI=10.1006/geno.1999.6022;
RA Kelsey G., Bodle D., Miller H.J., Beechey C.V., Coombes C., Peters J.,
RA Williamson C.M.;
RT "Identification of imprinted loci by methylation-sensitive representational
RT difference analysis: application to mouse distal chromosome 2.";
RL Genomics 62:129-138(1999).
RN [5]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106 AND ASN-537.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types. M-cadherin is part of the myogenic program
CC and may provide a trigger for terminal muscle differentiation.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Skeletal muscle.
CC -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC cadherin domain and rigidify the connections, imparting a strong
CC curvature to the full-length ectodomain. {ECO:0000250}.
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DR EMBL; BC157978; AAI57979.1; -; mRNA.
DR EMBL; M74541; AAC23585.1; -; mRNA.
DR EMBL; AJ245402; CAB57281.2; -; Genomic_DNA.
DR CCDS; CCDS22746.1; -.
DR PIR; A40986; IJMSCM.
DR RefSeq; NP_031688.2; NM_007662.2.
DR AlphaFoldDB; P33146; -.
DR SMR; P33146; -.
DR BioGRID; 198634; 2.
DR STRING; 10090.ENSMUSP00000034443; -.
DR GlyConnect; 2167; 1 N-Linked glycan (1 site).
DR GlyGen; P33146; 5 sites, 1 N-linked glycan (1 site).
DR iPTMnet; P33146; -.
DR PhosphoSitePlus; P33146; -.
DR PaxDb; P33146; -.
DR PeptideAtlas; P33146; -.
DR PRIDE; P33146; -.
DR ProteomicsDB; 281741; -.
DR Antibodypedia; 2417; 312 antibodies from 35 providers.
DR DNASU; 12555; -.
DR Ensembl; ENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962.
DR GeneID; 12555; -.
DR KEGG; mmu:12555; -.
DR UCSC; uc009ntv.1; mouse.
DR CTD; 1013; -.
DR MGI; MGI:106672; Cdh15.
DR VEuPathDB; HostDB:ENSMUSG00000031962; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000160118; -.
DR HOGENOM; CLU_005284_2_0_1; -.
DR InParanoid; P33146; -.
DR OMA; TTLYPWR; -.
DR OrthoDB; 395835at2759; -.
DR PhylomeDB; P33146; -.
DR TreeFam; TF316817; -.
DR Reactome; R-MMU-418990; Adherens junctions interactions.
DR Reactome; R-MMU-525793; Myogenesis.
DR BioGRID-ORCS; 12555; 2 hits in 75 CRISPR screens.
DR PRO; PR:P33146; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P33146; protein.
DR Bgee; ENSMUSG00000031962; Expressed in myotome and 88 other tissues.
DR Genevisible; P33146; MM.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0005901; C:caveola; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR Gene3D; 4.10.900.10; -; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; PTHR24027; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF01049; Cadherin_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; SSF49313; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 1: Evidence at protein level;
KW Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..59
FT /evidence="ECO:0000255"
FT /id="PRO_0000003807"
FT CHAIN 60..784
FT /note="Cadherin-15"
FT /id="PRO_0000003808"
FT TOPO_DOM 60..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 626..784
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 60..151
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 152..259
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 260..374
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 375..480
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 481..589
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 676..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 226
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 530
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 537
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 575
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 26
FT /note="K -> E (in Ref. 3; AAC23585)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="R -> H (in Ref. 3; AAC23585)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="L -> F (in Ref. 3; AAC23585)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 784 AA; 85644 MW; A21D73960A6F0063 CRC64;
MGSALLLALG LLAQSLGLSW AVPEPKPSTL YPWRRASAPG RVRRAWVIPP ISVSENHKRL
PYPLVQIKSD KQQLGSVIYS IQGPGVDEEP RNVFSIDKFT GRVYLNATLD REKTDRFRLR
AFALDLGGST LEDPTDLEIV VVDQNDNRPA FLQDVFRGRI LEGAIPGTFV TRAEATDADD
PETDNAALRF SILEQGSPEF FSIDEHTGEI RTVQVGLDRE VVAVYNLTLQ VADMSGDGLT
ATASAIISID DINDNAPEFT KDEFFMEAAE AVSGVDVGRL EVEDKDLPGS PNWVARFTIL
EGDPDGQFKI YTDPKTNEGV LSVVKPLDYE SREQYELRVS VQNEAPLQAA APRARRGQTR
VSVWVQDTNE APVFPENPLR TSIAEGAPPG TSVATFSARD PDTEQLQRIS YSKDYDPEDW
LQVDGATGRI QTQRVLSPAS PFLKDGWYRA IILALDNAIP PSTATGTLSI EILEVNDHAP
ALALPPSGSL CSEPDQGPGL LLGATDEDLP PHGAPFHFQL NPRVPDLGRN WSVSQINVSH
ARLRLRHQVS EGLHRLSLLL QDSGEPPQQR EQTLNVTVCR CGSDGTCLPG AAALRGGGVG
VSLGALVIVL ASTVVLLVLI LLAALRTRFR GHSRGKSLLH GLQEDLRDNI LNYDEQGGGE
EDQDAYDINQ LRHPVEPRAT SRSLGRPPLR RDAPFSYVPQ PHRVLPTSPS DIANFISDGL
EAADSDPSVP PYDTALIYDY EGDGSVAGTL SSILSSLGDE DQDYDYLRDW GPRFARLADM
YGHQ
