CACB3_RABIT
ID CACB3_RABIT Reviewed; 477 AA.
AC P54286;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit beta-3;
DE Short=CAB3 {ECO:0000303|PubMed:1312465};
DE AltName: Full=Calcium channel voltage-dependent subunit beta 3;
GN Name=CACNB3; Synonyms=CACNLB3;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=1312465; DOI=10.1002/j.1460-2075.1992.tb05126.x;
RA Hullin R., Singer-Lahat D., Freichel M., Biel M., Dascal N., Hofmann F.,
RA Flockerzi V.;
RT "Calcium channel beta subunit heterogeneity: functional expression of
RT cloned cDNA from heart, aorta and brain.";
RL EMBO J. 11:885-890(1992).
CC -!- FUNCTION: Regulatory subunit of the voltage-gated calcium channel that
CC gives rise to L-type calcium currents (PubMed:1312465). Increases
CC CACNA1B peak calcium current and shifts the voltage dependencies of
CC channel activation and inactivation (By similarity). Increases CACNA1C
CC peak calcium current and shifts the voltage dependencies of channel
CC activation and inactivation (By similarity).
CC {ECO:0000250|UniProtKB:P54287, ECO:0000250|UniProtKB:Q9MZL3,
CC ECO:0000269|PubMed:1312465}.
CC -!- SUBUNIT: Component of a calcium channel complex consisting of a pore-
CC forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and
CC CACNA2D1 (PubMed:1312465). The channel complex contains alpha, beta,
CC gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4.
CC Interacts with FASLG (By similarity). Interacts with CBARP; prevents
CC the interaction of CACNB3 with the alpha subunit CACNA1C thereby
CC negatively regulating the activity of the corresponding calcium channel
CC (By similarity). {ECO:0000250|UniProtKB:P54284,
CC ECO:0000250|UniProtKB:P54287, ECO:0000269|PubMed:1312465}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P54285}.
CC -!- TISSUE SPECIFICITY: Most abundant in brain but also present in aorta,
CC trachea and lung. {ECO:0000269|PubMed:1312465}.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000305}.
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DR EMBL; X64300; CAA45578.1; -; mRNA.
DR PIR; S21049; S21049.
DR RefSeq; NP_001095185.1; NM_001101715.2.
DR AlphaFoldDB; P54286; -.
DR SMR; P54286; -.
DR BioGRID; 1172422; 2.
DR STRING; 9986.ENSOCUP00000006399; -.
DR PRIDE; P54286; -.
DR GeneID; 100009402; -.
DR KEGG; ocu:100009402; -.
DR CTD; 784; -.
DR eggNOG; KOG3812; Eukaryota.
DR InParanoid; P54286; -.
DR OrthoDB; 926074at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR GO; GO:0061577; P:calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:UniProtKB.
DR GO; GO:1901843; P:positive regulation of high voltage-gated calcium channel activity; ISS:UniProtKB.
DR CDD; cd12042; SH3_CACNB3; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR035760; CACNB3_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR008079; VDCC_L_b3su.
DR InterPro; IPR000584; VDCC_L_bsu.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR PRINTS; PR01696; LCACHANNELB3.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Calcium; Calcium channel; Calcium transport; Cytoplasm; Ion channel;
KW Ion transport; Phosphoprotein; Reference proteome; SH3 domain; Transport;
KW Voltage-gated channel.
FT CHAIN 1..477
FT /note="Voltage-dependent L-type calcium channel subunit
FT beta-3"
FT /id="PRO_0000144058"
FT DOMAIN 59..128
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..345
FT /note="Mediates interaction with the alpha subunit"
FT /evidence="ECO:0000250|UniProtKB:P54287"
FT REGION 385..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P54287"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P54287"
SQ SEQUENCE 477 AA; 53814 MW; B9660513326511EB CRC64;
MYEDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV
AFAVRTNVSY CGVLDEECPV QGSGINFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS
PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV
VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER
SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT
HHPAPGPGLL GPPSAIPGLQ SQQLLGERGE EHSPLERDSL MPSDEAWTGS SQRSSRHLEE
DYADAYQDLY QPHRQHTSGL PSANGHDPQD RLLAQDSEHN HNDRNWQRNR PWPKDSY
