UNC37_CAEEL
ID UNC37_CAEEL Reviewed; 612 AA.
AC O02482; P91912;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Transcription factor unc-37;
DE AltName: Full=Uncoordinated protein 37;
GN Name=unc-37; Synonyms=esg; ORFNames=W02D3.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Bristol N2;
RX PubMed=9165118; DOI=10.1242/dev.124.9.1699;
RA Pflugrad A., Meir J.Y.-J., Barnes T.M., Miller D.M. III;
RT "The Groucho-like transcription factor UNC-37 functions with the neural
RT specificity gene unc-4 to govern motor neuron identity in C. elegans.";
RL Development 124:1699-1709(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Bristol N2;
RX PubMed=9350340; DOI=10.1080/15216549700204111;
RA Sharief F.S., Tsoi S.C.M., Li S.S.-L.;
RT "cDNA cloning and genomic organization of enhancer of split groucho gene
RT from nematode Caenorhabditis elegans.";
RL Biochem. Mol. Biol. Int. 43:327-337(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP INTERACTION WITH UNC-4.
RX PubMed=10557206; DOI=10.1101/gad.13.21.2774;
RA Winnier A.R., Meir J.Y.-J., Ross J.M., Tavernarakis N., Driscoll M.,
RA Ishihara T., Katsura I., Miller D.M. III;
RT "UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls
RT synaptic choice in Caenorhabditis elegans.";
RL Genes Dev. 13:2774-2786(1999).
RN [5]
RP FUNCTION, INTERACTION WITH MLS-1, AND DISRUPTION PHENOTYPE.
RX PubMed=21852953; DOI=10.1371/journal.pgen.1002210;
RA Miller R.R., Okkema P.G.;
RT "The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-
RT repressor interaction for uterine muscle specification.";
RL PLoS Genet. 7:E1002210-E1002210(2011).
CC -!- FUNCTION: Transcriptional corepressor that functions with the neural
CC specificity gene unc-4 to govern motor neuron identity
CC (PubMed:9165118). May function with transcription factor mls-1 to
CC promote uterine muscle specification and formation (PubMed:21852953).
CC {ECO:0000269|PubMed:21852953, ECO:0000269|PubMed:9165118}.
CC -!- SUBUNIT: Interacts with unc-4 (PubMed:10557206). May interact with mls-
CC 1 (PubMed:21852953). {ECO:0000269|PubMed:10557206,
CC ECO:0000269|PubMed:21852953}.
CC -!- INTERACTION:
CC O02482; O62505: CELE_ZK1053.3; NbExp=4; IntAct=EBI-314716, EBI-326955;
CC O02482; G5ECN8: ces-1; NbExp=4; IntAct=EBI-314716, EBI-322161;
CC O02482; Q93616: lsy-22; NbExp=7; IntAct=EBI-314716, EBI-2005589;
CC O02482; Q9XVV3: nhr-67; NbExp=3; IntAct=EBI-314716, EBI-314697;
CC O02482; G5ED66: pax-3; NbExp=5; IntAct=EBI-314716, EBI-2416749;
CC O02482; Q10666: pop-1; NbExp=3; IntAct=EBI-314716, EBI-317870;
CC O02482; Q22678: sptf-2; NbExp=5; IntAct=EBI-314716, EBI-2420648;
CC O02482; Q18694: unc-130; NbExp=3; IntAct=EBI-314716, EBI-2414897;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Maternal effect embryonic lethal. RNAi-mediated
CC knockdown results in reduced uterine cell specification.
CC {ECO:0000269|PubMed:21852953}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
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DR EMBL; U89245; AAB49459.1; -; mRNA.
DR EMBL; AF001271; AAB84234.1; -; mRNA.
DR EMBL; AF001272; AAB84235.1; -; Genomic_DNA.
DR EMBL; FO081084; CCD68992.1; -; Genomic_DNA.
DR PIR; T15211; T15211.
DR RefSeq; NP_491932.1; NM_059531.6.
DR AlphaFoldDB; O02482; -.
DR SMR; O02482; -.
DR BioGRID; 37842; 54.
DR DIP; DIP-27333N; -.
DR IntAct; O02482; 48.
DR STRING; 6239.W02D3.9.1; -.
DR EPD; O02482; -.
DR PaxDb; O02482; -.
DR PeptideAtlas; O02482; -.
DR EnsemblMetazoa; W02D3.9.1; W02D3.9.1; WBGene00006773.
DR GeneID; 172394; -.
DR KEGG; cel:CELE_W02D3.9; -.
DR UCSC; W02D3.9.2; c. elegans.
DR CTD; 172394; -.
DR WormBase; W02D3.9; CE14434; WBGene00006773; unc-37.
DR eggNOG; KOG0639; Eukaryota.
DR GeneTree; ENSGT01030000234519; -.
DR HOGENOM; CLU_007612_3_0_1; -.
DR InParanoid; O02482; -.
DR OMA; PNDEWVA; -.
DR OrthoDB; 546143at2759; -.
DR PhylomeDB; O02482; -.
DR Reactome; R-CEL-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-CEL-3769402; Deactivation of the beta-catenin transactivating complex.
DR Reactome; R-CEL-4641265; Repression of WNT target genes.
DR SignaLink; O02482; -.
DR PRO; PR:O02482; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00006773; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
DR GO; GO:0007268; P:chemical synaptic transmission; IMP:WormBase.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:WormBase.
DR GO; GO:0050770; P:regulation of axonogenesis; IMP:WormBase.
DR GO; GO:0001505; P:regulation of neurotransmitter levels; IDA:WormBase.
DR GO; GO:0050803; P:regulation of synapse structure or activity; IMP:WormBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10814; PTHR10814; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Developmental protein; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..612
FT /note="Transcription factor unc-37"
FT /id="PRO_0000051316"
FT REPEAT 308..339
FT /note="WD 1"
FT REPEAT 372..402
FT /note="WD 2"
FT REPEAT 414..444
FT /note="WD 3"
FT REPEAT 456..486
FT /note="WD 4"
FT REPEAT 538..568
FT /note="WD 5"
FT REPEAT 579..609
FT /note="WD 6"
FT REGION 143..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..196
FT /note="CCN domain"
FT COMPBIAS 184..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="K -> T (in Ref. 1; AAB49459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 612 AA; 65617 MW; D3AFF39E526F8249 CRC64;
MKASYLETLD RIKDEHAEMS KHVNQQRSDI EKVALEKENM NRSYMTYAEV SNTLRSDLRK
AEEINKRLQE FIMQSLAPQL SQDNQANCLA ALEAFKTASP RENGNGAPAL PPGFPPGAAG
MLGMMPNMPF GMSPAMSQLF NQFASPHVNG GDGAGGSSGG ASEAKKAKLE DPDDGELEID
VTNDDHPSTA SNGGAANKNG RDSTNSVASS GASTPSIASN SRARQQQQPL AGLQGLEQMN
FLAGFNPNLL RQASAAGGFN FLNDPHAQAR LAAAIGQIGS RPAYSFKIVD GGVPTPTSFP
PDAQKGPGIP TGLKKKMELN HGEVVCAATI SRDNSRVYTG GKGCVKIWDV KESDISGATV
VNRPPIASLD CLKENYIRSC KLFEDGNTLL IGGEASTVAL WDLTTETKTL DLETDSQACY
ALAMSPDEKL LFACLADGNI LIYDIHNKVK VGTLPGHQDG ASCLDLSKDG TKLWSGGLDN
SVRCWDLAQR KEVAKHDFAS QVFSLGCCPN DEWVAVGMEN NYVEVLSTTG KEKYQLTQHE
SCVLSLKFAH SGKFFISTGK DNALNAWRTP YGASLFQLKE NSSVLSCDIS FDDSLIVTGS
GEKKATLYAV EY
