ID   UL92_HHV8P              Reviewed;         194 AA.
AC   Q2HRA1;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein ORF31;
DE   Flags: Precursor;
GN   Name=ORF31;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=15163752; DOI=10.1128/jvi.78.12.6610-6620.2004;
RA   Jia Q., Wu T.T., Liao H.I., Chernishof V., Sun R.;
RT   "Murine gammaherpesvirus 68 open reading frame 31 is required for viral
RT   replication.";
RL   J. Virol. 78:6610-6620(2004).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH ORF34.
RX   PubMed=25810551; DOI=10.1128/jvi.00272-15;
RA   Brulois K., Wong L.Y., Lee H.R., Sivadas P., Ensser A., Feng P., Gao S.J.,
RA   Toth Z., Jung J.U.;
RT   "Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34
RT   and ORF24 Is Critical for Late Gene Expression.";
RL   J. Virol. 89:6148-6154(2015).
RN   [5]
RP   FUNCTION, INTERACTION WITH ORF34, AND SUBCELLULAR LOCATION.
RX   PubMed=28336944; DOI=10.1038/s41598-017-00401-7;
RA   Nishimura M., Watanabe T., Yagi S., Yamanaka T., Fujimuro M.;
RT   "Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene
RT   expression and virus production.";
RL   Sci. Rep. 7:329-329(2017).
CC   -!- FUNCTION: Plays an important role in the expression of late genes
CC       (PubMed:25810551, PubMed:28336944). May play a role in viral
CC       replication (PubMed:15163752). {ECO:0000269|PubMed:15163752,
CC       ECO:0000269|PubMed:25810551, ECO:0000269|PubMed:28336944}.
CC   -!- SUBUNIT: Interacts with ORF34. {ECO:0000269|PubMed:25810551,
CC       ECO:0000269|PubMed:28336944}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:28336944}. Host
CC       cytoplasm {ECO:0000269|PubMed:28336944}. Note=Mainly localizes in host
CC       nucleus and partially in host cytosol. {ECO:0000269|PubMed:28336944}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL92 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28881.1; -; Genomic_DNA.
DR   RefSeq; YP_001129384.1; NC_009333.1.
DR   BioGRID; 1777001; 1.
DR   PRIDE; Q2HRA1; -.
DR   GeneID; 4961498; -.
DR   KEGG; vg:4961498; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004289; Herpes_UL92.
DR   Pfam; PF03048; Herpes_UL92; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..194
FT                   /note="Protein ORF31"
FT                   /id="PRO_0000423789"
SQ   SEQUENCE   194 AA;  21729 MW;  05CA419A7F33219F CRC64;
     MKSVASPLCQ FHGVFCLYQC RQCLAYHVCD GGAECVLLHT PESVICELTG NCMLGNIQEG
     QFLGPVPYRT LDNQVDRDAY HGMLACLKRD IVRYLQTWPD TTVIVQEIAL GDGVTDTISA
     IIDETFGECL PVLGEAQGGY ALVCSMYLHV IVSIYSTKTV YNSMLFKCTK NKKYDCIAKR
     VRTKWMRMLS TKDT