ID   CA122_CONBU             Reviewed;          41 AA.
AC   P0CY77;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Bu22;
DE   Flags: Precursor; Fragment;
OS   Conus bullatus (Bubble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX   NCBI_TaxID=89438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA   Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT   "Characterization of the Conus bullatus genome and its venom-duct
RT   transcriptome.";
RL   BMC Genomics 12:60-60(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21266071}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21266071}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/6 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CY77; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..25
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409969"
FT   PEPTIDE         26..41
FT                   /note="Conotoxin Bu22"
FT                   /id="PRO_0000409970"
FT   DISULFID        27..33
FT                   /evidence="ECO:0000250|UniProtKB:K8DWB5"
FT   DISULFID        28..40
FT                   /evidence="ECO:0000250|UniProtKB:K8DWB5"
FT   NON_TER         1
SQ   SEQUENCE   41 AA;  4226 MW;  633EE8C2785B5905 CRC64;
     SDRASDGRNA AANDRASDLV ALTVRGCCTY PPCAVLSPLC D