ID   UFL1_TRIAD              Reviewed;         780 AA.
AC   B3RYG4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=TRIADDRAFT_25797;
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax.
OX   NCBI_TaxID=10228;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999;
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; DS985245; EDV25034.1; -; Genomic_DNA.
DR   RefSeq; XP_002112924.1; XM_002112888.1.
DR   AlphaFoldDB; B3RYG4; -.
DR   STRING; 10228.TriadP25797; -.
DR   EnsemblMetazoa; TriadT25797; TriadP25797; TriadG25797.
DR   GeneID; 6754137; -.
DR   KEGG; tad:TRIADDRAFT_25797; -.
DR   CTD; 6754137; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; B3RYG4; -.
DR   OMA; NECSATK; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; B3RYG4; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..780
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391897"
FT   REGION          403..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..752
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   780 AA;  88685 MW;  F1F9C86E7076081C CRC64;
     MSDWNEIQRL AADFQRIQLT ASAHQLSERN CIEIITKLIA MNKVQVMYTI DGKEYLTPQQ
     LEREIRDELF VHSGRINLVE LQQVINVDLT HIDSKVKEML RGDRSLYLIQ GDLIDRDYID
     RLAEEINDIL QESGQISVSE LGKTFNLPTD FLQTNIEKRM GIYIHGQVNP LERGTIYTEA
     YVARHAAKIR GVFSAITRPT SVSSIIYQYS FPEALLHDIL RKLLDEKRLA GSVQGHQSKA
     IYTPNIYSRT QSNWVLSFFR QNDYIEYDSL TRLDITDPKN YLKKCLNKNV IFLESCVSGQ
     NILGQVQAAI EDVVATPSWV DIMTLLPSPF TTGDASVLLQ KHCLKSNKNN TSVQCLCDKF
     VVSNKFIQNC LQLFDDHMKT KAEKVYFHLL FIDAGKVAAK FASTSSTNPN HSTLTKHDDS
     NVTGGKKKKG DDSTSSKRKG KGKDRSTPDD LESTRSHIKQ NKQDLEFMAI PEIIEVLQRE
     HSNCEDQFLE EIASQLFSPL KRKYQEVAKS VFLASTSSVT SEKRKLHSDA QDKINGLLTN
     AKLFGKGLQH FSGDAHTTLG KHLLHTLCTE ITNIVFSLLI SEHIMVDSDP NSLNPETRSS
     ALEKFPNNVK KAASALEKSL SGKDVEQFFD ALDVVLGPSI CQIMIKKLDK KKERQIIFNH
     RQSLIEQLNK ESKPAMCLHL CTLLLFQRHT QCMIHAPGRC IPQIISFLKQ HLTDEQYKTI
     YEYQQLIIQS IQQSSDKQKP EMSEEPKDSD NSNDNQNIDL QLQEKMTTIK AIALENKKQS