CA112_MOUSE
ID CA112_MOUSE Reviewed; 903 AA.
AC Q3TQQ9; Q3UR98; Q5RKU3; Q7TMQ3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized protein C1orf112 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C3H/He, and C57BL/6J; TISSUE=Brain, and Osteoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3TQQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TQQ9-2; Sequence=VSP_023447;
CC Name=3;
CC IsoId=Q3TQQ9-3; Sequence=VSP_023446;
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DR EMBL; AK141661; BAE24790.1; -; mRNA.
DR EMBL; AK163374; BAE37323.1; -; mRNA.
DR EMBL; BC052855; AAH52855.1; -; mRNA.
DR EMBL; BC055324; AAH55324.1; -; mRNA.
DR CCDS; CCDS35752.1; -. [Q3TQQ9-1]
DR CCDS; CCDS87908.1; -. [Q3TQQ9-2]
DR RefSeq; NP_958752.1; NM_201364.1. [Q3TQQ9-1]
DR AlphaFoldDB; Q3TQQ9; -.
DR BioGRID; 237868; 1.
DR STRING; 10090.ENSMUSP00000043143; -.
DR iPTMnet; Q3TQQ9; -.
DR PhosphoSitePlus; Q3TQQ9; -.
DR EPD; Q3TQQ9; -.
DR MaxQB; Q3TQQ9; -.
DR PaxDb; Q3TQQ9; -.
DR PeptideAtlas; Q3TQQ9; -.
DR PRIDE; Q3TQQ9; -.
DR Antibodypedia; 20545; 86 antibodies from 14 providers.
DR Ensembl; ENSMUST00000045876; ENSMUSP00000043143; ENSMUSG00000041406. [Q3TQQ9-1]
DR Ensembl; ENSMUST00000097493; ENSMUSP00000095101; ENSMUSG00000041406. [Q3TQQ9-2]
DR GeneID; 381306; -.
DR KEGG; mmu:381306; -.
DR UCSC; uc007dhs.1; mouse. [Q3TQQ9-2]
DR UCSC; uc007dhu.1; mouse. [Q3TQQ9-1]
DR MGI; MGI:3590554; BC055324.
DR VEuPathDB; HostDB:ENSMUSG00000041406; -.
DR eggNOG; ENOG502QQPV; Eukaryota.
DR GeneTree; ENSGT00390000004791; -.
DR HOGENOM; CLU_335441_0_0_1; -.
DR InParanoid; Q3TQQ9; -.
DR OMA; NLPLWQY; -.
DR OrthoDB; 1492467at2759; -.
DR PhylomeDB; Q3TQQ9; -.
DR TreeFam; TF328571; -.
DR BioGRID-ORCS; 381306; 11 hits in 75 CRISPR screens.
DR PRO; PR:Q3TQQ9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3TQQ9; protein.
DR Bgee; ENSMUSG00000041406; Expressed in urogenital fold and 141 other tissues.
DR ExpressionAtlas; Q3TQQ9; baseline and differential.
DR Genevisible; Q3TQQ9; MM.
DR InterPro; IPR027902; DUF4487.
DR PANTHER; PTHR16071; PTHR16071; 1.
DR Pfam; PF14868; DUF4487; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..903
FT /note="Uncharacterized protein C1orf112 homolog"
FT /id="PRO_0000279462"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NSG2"
FT MOD_RES 843
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NSG2"
FT VAR_SEQ 59..116
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023446"
FT VAR_SEQ 903
FT /note="G -> GGSTCAQSPRPALTRFDTLPLPTWL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023447"
FT CONFLICT 261
FT /note="K -> R (in Ref. 1; BAE24790)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="M -> R (in Ref. 1; BAE24790)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="I -> M (in Ref. 2; AAH52855)"
FT /evidence="ECO:0000305"
FT CONFLICT 539
FT /note="P -> H (in Ref. 1; BAE24790)"
FT /evidence="ECO:0000305"
FT CONFLICT 897
FT /note="K -> E (in Ref. 2; AAH52855)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 903 AA; 101222 MW; C3825902D248AF64 CRC64;
MSQDDAEVAS GVVLEELSSW SEEMCRRELP SVLPRLLSMY QCSESWIEHI RILKIIVEMF
LPHMNHLTLE ETLFSQVLPK SIKLFDGMIC ELTSEARELS SQNLEIQVTI RNILQAMVQV
IGGFTGCVRH VCATQKSVFL GSIQSLPSFI LHIIKSAFVH CKNSECVYSG RLHLVSDLLQ
VLFKEAYSLQ KQLMGLLDTV CLDPSVDENN ALIMVGVIHS LLDICSVISG MDQAFHANTW
KFIIKQSLKH HSVIKSQLRH KEIISSLCED ILFSFHSCLQ LAEQITQPAA QGNADYRLFQ
KTLKLCRFFA NSLLHYTKEC LPFLSDSCCT LHQLYLQIHS KFLSLCAAKT SKAQQEEIAS
TFLVLLDPLI SQLLKSQPFV QAVLASKLAL PCELQLPQVL LLVVAMDKLP SQPQDVQTLW
STEDMTRMSI LKGIFYNFGQ CSGELSLPTH LQGTKGKGQA EVPVTLYQHV CVHLCAFVAS
FHSSLFPRLD AALLNAVLST NMSTSLLAMD VWCFLARYGT AKLGAHHVTL VAHLVKSCPG
KCVQLTNLSI LLKRLLFFMA APHQVQFIQK FSPKEADNLH LWQYISLQAF DADLRKPVAC
ELVRVCRAQC RKWLSSTRTL AELDSLNTAL SVVLTVCNSA GEALDSRQLT AVTEVLGELW
TFINVEQIIS QPYVQQAFSL LLQLLAFFIQ TVDLQLISQV VNVLTSVIKL EPPDHVSLAV
LDFISSLGKL YISQTIRDKV LPSLSCILTS LIVNKNWLLE QHTLEAFTQF AEGTKHEEIV
PQCLGSEEIK NKVVSFLEKT ESVDEAEVAT VDNVKQEKGT FWEPAAKVTV EEVKTSAFQP
HTKRARRVLP FEEEYRSVFK AAARALETTE FLLKHSLAPA WLLPELEALQ GRIEKLKRCV
LTG
