CA112_HUMAN
ID CA112_HUMAN Reviewed; 853 AA.
AC Q9NSG2; A6NFP1; B3KU42; Q3KNQ1; Q9H8L5; Q9NVJ0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized protein C1orf112;
GN Name=C1orf112;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Rhodes S., Huckle E.;
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain, Placenta, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-792, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9NSG2; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-11128910, EBI-10181968;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NSG2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NSG2-2; Sequence=VSP_023445;
CC Name=3;
CC IsoId=Q9NSG2-3; Sequence=VSP_023444;
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DR EMBL; AL354614; CAB89727.1; -; mRNA.
DR EMBL; AK001568; BAA91761.1; -; mRNA.
DR EMBL; AK023532; BAB14600.1; -; mRNA.
DR EMBL; AK096493; BAG53304.1; -; mRNA.
DR EMBL; AL021940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90863.1; -; Genomic_DNA.
DR EMBL; BC091516; AAH91516.1; -; mRNA.
DR EMBL; BC107168; AAI07169.1; -; mRNA.
DR EMBL; BC107169; AAI07170.1; -; mRNA.
DR CCDS; CCDS1285.1; -. [Q9NSG2-1]
DR CCDS; CCDS86030.1; -. [Q9NSG2-3]
DR RefSeq; NP_001306976.1; NM_001320047.1. [Q9NSG2-1]
DR RefSeq; NP_001306977.1; NM_001320048.1. [Q9NSG2-2]
DR RefSeq; NP_001306979.1; NM_001320050.1.
DR RefSeq; NP_001306980.1; NM_001320051.1.
DR RefSeq; NP_060656.2; NM_018186.3.
DR RefSeq; XP_011508037.1; XM_011509735.2. [Q9NSG2-3]
DR RefSeq; XP_016857213.1; XM_017001724.1.
DR RefSeq; XP_016857214.1; XM_017001725.1.
DR AlphaFoldDB; Q9NSG2; -.
DR BioGRID; 120851; 60.
DR IntAct; Q9NSG2; 22.
DR STRING; 9606.ENSP00000286031; -.
DR iPTMnet; Q9NSG2; -.
DR PhosphoSitePlus; Q9NSG2; -.
DR BioMuta; C1orf112; -.
DR DMDM; 74761679; -.
DR EPD; Q9NSG2; -.
DR jPOST; Q9NSG2; -.
DR MassIVE; Q9NSG2; -.
DR MaxQB; Q9NSG2; -.
DR PaxDb; Q9NSG2; -.
DR PeptideAtlas; Q9NSG2; -.
DR PRIDE; Q9NSG2; -.
DR ProteomicsDB; 82548; -. [Q9NSG2-1]
DR ProteomicsDB; 82549; -. [Q9NSG2-2]
DR ProteomicsDB; 82550; -. [Q9NSG2-3]
DR Antibodypedia; 20545; 86 antibodies from 14 providers.
DR DNASU; 55732; -.
DR Ensembl; ENST00000286031.10; ENSP00000286031.6; ENSG00000000460.17. [Q9NSG2-1]
DR Ensembl; ENST00000359326.9; ENSP00000352276.4; ENSG00000000460.17. [Q9NSG2-1]
DR Ensembl; ENST00000413811.3; ENSP00000389257.3; ENSG00000000460.17. [Q9NSG2-3]
DR GeneID; 55732; -.
DR KEGG; hsa:55732; -.
DR MANE-Select; ENST00000359326.9; ENSP00000352276.4; NM_001320047.2; NP_001306976.1.
DR UCSC; uc001ggp.4; human. [Q9NSG2-1]
DR CTD; 55732; -.
DR DisGeNET; 55732; -.
DR GeneCards; C1orf112; -.
DR HGNC; HGNC:25565; C1orf112.
DR HPA; ENSG00000000460; Tissue enhanced (parathyroid).
DR neXtProt; NX_Q9NSG2; -.
DR OpenTargets; ENSG00000000460; -.
DR PharmGKB; PA142672496; -.
DR VEuPathDB; HostDB:ENSG00000000460; -.
DR eggNOG; ENOG502QQPV; Eukaryota.
DR GeneTree; ENSGT00390000004791; -.
DR HOGENOM; CLU_335441_0_0_1; -.
DR InParanoid; Q9NSG2; -.
DR OMA; NLPLWQY; -.
DR OrthoDB; 1492467at2759; -.
DR PhylomeDB; Q9NSG2; -.
DR TreeFam; TF328571; -.
DR PathwayCommons; Q9NSG2; -.
DR SignaLink; Q9NSG2; -.
DR BioGRID-ORCS; 55732; 25 hits in 1053 CRISPR screens.
DR ChiTaRS; C1orf112; human.
DR GenomeRNAi; 55732; -.
DR Pharos; Q9NSG2; Tdark.
DR PRO; PR:Q9NSG2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NSG2; protein.
DR Bgee; ENSG00000000460; Expressed in ventricular zone and 103 other tissues.
DR ExpressionAtlas; Q9NSG2; baseline and differential.
DR Genevisible; Q9NSG2; HS.
DR InterPro; IPR027902; DUF4487.
DR PANTHER; PTHR16071; PTHR16071; 1.
DR Pfam; PF14868; DUF4487; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..853
FT /note="Uncharacterized protein C1orf112"
FT /id="PRO_0000279461"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 792
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT VAR_SEQ 1..323
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023444"
FT VAR_SEQ 1..135
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023445"
FT VARIANT 481
FT /note="A -> S (in dbSNP:rs2272920)"
FT /id="VAR_030906"
FT CONFLICT 594
FT /note="D -> G (in Ref. 2; BAB14600)"
FT /evidence="ECO:0000305"
FT CONFLICT 655
FT /note="S -> L (in Ref. 2; BAA91761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 853 AA; 96554 MW; E7FCA875C87052B1 CRC64;
MFLPHMNHLT LEQTFFSQVL PKTVKLFDDM MYELTSQARG LSSQNLEIQT TLRNILQTMV
QLLGALTGCV QHICATQESI ILENIQSLPS SVLHIIKSTF VHCKNSESVY SGCLHLVSDL
LQALFKEAYS LQKQLMELLD MVCMDPLVDD NDDILNMVIV IHSLLDICSV ISSMDHAFHA
NTWKFIIKQS LKHQSIIKSQ LKHKDIITSL CEDILFSFHS CLQLAEQMTQ SDAQDNADYR
LFQKTLKLCR FFANSLLHYA KEFLPFLSDS CCTLHQLYLQ IHSKFPPSLY ATRISKAHQE
EIAGAFLVTL DPLISQLLTF QPFMQVVLDS KLDLPCELQF PQCLLLVVVM DKLPSQPKEV
QTLWCTDSQV SETTTRISLL KAVFYSFEQC SGELSLPVHL QGLKSKGKAE VAVTLYQHVC
VHLCTFITSF HPSLFAELDA ALLNAVLSAN MITSLLAMDA WCFLARYGTA ELCAHHVTIV
AHLIKSCPGE CYQLINLSIL LKRLFFFMAP PHQLEFIQKF SPKEAENLPL WQHISFQALP
PELREQTVHE VTTVGTAECR KWLSRSRTLG ELESLNTVLS ALLAVCNSAG EALDTGKQTA
IIEVVSQLWA FLNIKQVADQ PYVQQTFSLL LPLLGFFIQT LDPKLILQAV TLQTSLLKLE
LPDYVRLAML DFVSSLGKLF IPEAIQDRIL PNLSCMFALL LADRSWLLEQ HTLEAFTQFA
EGTNHEEIVP QCLSSEETKN KVVSFLEKTG FVDETEAAKV ERVKQEKGIF WEPFANVTVE
EAKRSSLQPY AKRARQEFPW EEEYRSALHT IAGALEATES LLQKGPAPAW LSMEMEALQE
RMDKLKRYIH TLG
