ID   CA112_CONBU             Reviewed;          59 AA.
AC   P0CY87;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Conotoxin Bu1.2;
DE   Flags: Precursor;
OS   Conus bullatus (Bubble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX   NCBI_TaxID=89438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Watkins M., Hillyard D.R., McIntosh M.J., Jones R.M., Olivera B.M.;
RT   "Alpha-conotoxin peptides.";
RL   Patent number EP1852440, 07-NOV-2007.
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=20143226; DOI=10.1007/s00239-010-9321-7;
RA   Puillandre N., Watkins M., Olivera B.M.;
RT   "Evolution of conus peptide genes: duplication and positive selection in
RT   the A-Superfamily.";
RL   J. Mol. Evol. 70:190-202(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/4 pattern.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   EMBL; FB299972; CAR81557.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P0CY87; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..42
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409990"
FT   PEPTIDE         43..58
FT                   /note="Conotoxin Bu1.2"
FT                   /id="PRO_0000409991"
FT   REGION          18..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         58
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..52
FT                   /evidence="ECO:0000250|UniProtKB:P69657"
FT   DISULFID        47..57
FT                   /evidence="ECO:0000250|UniProtKB:P69657"
SQ   SEQUENCE   59 AA;  6205 MW;  0BCD97228FCD990F CRC64;
     MFTVFLLVVL ATTVVSFSTD DESDGSNEEP SADQAARSAM NRPPGCCNNP ACVKHRCGG