CA109_MOUSE
ID CA109_MOUSE Reviewed; 217 AA.
AC Q499E6; Q148T1; Q3TU44; Q8BI05;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Ribosome biogenesis protein C1orf109 homolog {ECO:0000305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the cytoplasmic maturation steps of pre-60S
CC ribosomal particles by promoting the release of shuttling protein
CC RSL24D1/RLP24 from the pre-ribosomal particles. Acts together with
CC SPATA5, SPATA5L1 and CINP. {ECO:0000250|UniProtKB:Q9NX04}.
CC -!- SUBUNIT: Interacts with SPATA5, SPATA5L1 and CINP. Does not associate
CC with pre-60S ribosomal particles. {ECO:0000250|UniProtKB:Q9NX04}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NX04}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9NX04}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q499E6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q499E6-2; Sequence=VSP_022736;
CC Name=3;
CC IsoId=Q499E6-3; Sequence=VSP_022735;
CC -!- PTM: Phosphorylated on serines by CK2 kinase.
CC {ECO:0000250|UniProtKB:Q9NX04}.
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DR EMBL; AK037053; BAC29685.1; -; mRNA.
DR EMBL; AK158126; BAE34372.1; -; mRNA.
DR EMBL; AK160978; BAE36127.1; -; mRNA.
DR EMBL; BC099946; AAH99946.1; -; mRNA.
DR EMBL; BC117984; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS89826.1; -. [Q499E6-1]
DR RefSeq; NP_808241.2; NM_177573.3. [Q499E6-1]
DR RefSeq; XP_006502949.1; XM_006502886.3.
DR AlphaFoldDB; Q499E6; -.
DR SMR; Q499E6; -.
DR IntAct; Q499E6; 1.
DR PhosphoSitePlus; Q499E6; -.
DR MaxQB; Q499E6; -.
DR PRIDE; Q499E6; -.
DR ProteomicsDB; 273863; -. [Q499E6-1]
DR ProteomicsDB; 273864; -. [Q499E6-2]
DR ProteomicsDB; 273865; -. [Q499E6-3]
DR Antibodypedia; 17567; 50 antibodies from 9 providers.
DR Ensembl; ENSMUST00000094769; ENSMUSP00000154851; ENSMUSG00000044730. [Q499E6-1]
DR GeneID; 194268; -.
DR KEGG; mmu:194268; -.
DR UCSC; uc008url.1; mouse. [Q499E6-1]
DR UCSC; uc008urm.1; mouse. [Q499E6-3]
DR MGI; MGI:3041172; 9930104L06Rik.
DR VEuPathDB; HostDB:ENSMUSG00000044730; -.
DR GeneTree; ENSGT00390000008551; -.
DR InParanoid; Q499E6; -.
DR OMA; SHVEQVF; -.
DR OrthoDB; 1504674at2759; -.
DR PhylomeDB; Q499E6; -.
DR BioGRID-ORCS; 194268; 4 hits in 17 CRISPR screens.
DR PRO; PR:Q499E6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q499E6; protein.
DR Bgee; ENSMUSG00000044730; Expressed in retinal neural layer and 211 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR InterPro; IPR029159; CK2S.
DR PANTHER; PTHR16234; PTHR16234; 1.
DR Pfam; PF15011; CK2S; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Ribosome biogenesis.
FT CHAIN 1..217
FT /note="Ribosome biogenesis protein C1orf109 homolog"
FT /id="PRO_0000274383"
FT VAR_SEQ 93..217
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022735"
FT VAR_SEQ 151..217
FT /note="SSYLKRKYLLSSIHWGDLASIQALPKAWDQISENECQTLVSDVLVSVSFFLE
FT EPGGCAASGDLEHHS -> GSYPSSAS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022736"
FT CONFLICT 62
FT /note="A -> S (in Ref. 2; BC117984)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24442 MW; 891D3EE1FC57426E CRC64;
MAHDQPLLVV QEALRKCFPV VEEQQNLWQS TLQDCSPLLS SLSNLAEQLQ AAQSLRFEDV
PALRPFPDLQ ERLRRKQLEA GDVVLDKLAE RLATLLKVRN TINSHVEQVF QAYEQHAAVL
DIDTVLRPSV VSPSVADMLE WLQDIDRHYG SSYLKRKYLL SSIHWGDLAS IQALPKAWDQ
ISENECQTLV SDVLVSVSFF LEEPGGCAAS GDLEHHS
