CA109_HUMAN
ID CA109_HUMAN Reviewed; 203 AA.
AC Q9NX04; D3DPT1; Q8WVD1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Ribosome biogenesis protein C1orf109 {ECO:0000305};
GN Name=C1orf109 {ECO:0000303|PubMed:35354024, ECO:0000312|HGNC:HGNC:26039};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, MUTAGENESIS OF SER-104; SER-134 AND SER-182, AND
RP PHOSPHORYLATION BY CK2.
RX PubMed=22548824; DOI=10.1186/1423-0127-19-49;
RA Liu S.S., Zheng H.X., Jiang H.D., He J., Yu Y., Qu Y.P., Yue L., Zhang Y.,
RA Li Y.;
RT "Identification and characterization of a novel gene, c1orf109, encoding a
RT CK2 substrate that is involved in cancer cell proliferation.";
RL J. Biomed. Sci. 19:49-49(2012).
RN [5]
RP FUNCTION, AND INTERACTION WITH SPATA5; SPATA5L1 AND CINP.
RX PubMed=35354024; DOI=10.1016/j.celrep.2022.110597;
RA Ni C., Schmitz D.A., Lee J., Pawlowski K., Wu J., Buszczak M.;
RT "Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a
RT late step in human ribosome assembly.";
RL Cell Rep. 38:110597-110597(2022).
CC -!- FUNCTION: Involved in the cytoplasmic maturation steps of pre-60S
CC ribosomal particles by promoting the release of shuttling protein
CC RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts
CC together with SPATA5, SPATA5L1 and CINP (PubMed:35354024).
CC {ECO:0000269|PubMed:35354024}.
CC -!- SUBUNIT: Interacts with SPATA5, SPATA5L1 and CINP (PubMed:35354024).
CC Does not associate with pre-60S ribosomal particles (PubMed:35354024).
CC {ECO:0000269|PubMed:35354024}.
CC -!- INTERACTION:
CC Q9NX04; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-8643161, EBI-11096309;
CC Q9NX04; Q96D30: ADD1; NbExp=5; IntAct=EBI-8643161, EBI-9089447;
CC Q9NX04; Q9BQD7: ANTKMT; NbExp=3; IntAct=EBI-8643161, EBI-713602;
CC Q9NX04; Q9Y6H3: ATP23; NbExp=3; IntAct=EBI-8643161, EBI-12811889;
CC Q9NX04; Q5T686: AVPI1; NbExp=3; IntAct=EBI-8643161, EBI-8640233;
CC Q9NX04; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-8643161, EBI-10193358;
CC Q9NX04; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-8643161, EBI-946029;
CC Q9NX04; Q9BXJ5: C1QTNF2; NbExp=3; IntAct=EBI-8643161, EBI-2817707;
CC Q9NX04; Q8NA61: CBY2; NbExp=3; IntAct=EBI-8643161, EBI-741724;
CC Q9NX04; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-8643161, EBI-11524851;
CC Q9NX04; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-8643161, EBI-744556;
CC Q9NX04; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-8643161, EBI-11977221;
CC Q9NX04; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-8643161, EBI-347573;
CC Q9NX04; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-8643161, EBI-10175300;
CC Q9NX04; Q9BXL8: CDCA4; NbExp=3; IntAct=EBI-8643161, EBI-1773949;
CC Q9NX04; Q53EZ4: CEP55; NbExp=6; IntAct=EBI-8643161, EBI-747776;
CC Q9NX04; Q9BW66: CINP; NbExp=9; IntAct=EBI-8643161, EBI-739784;
CC Q9NX04; O43186: CRX; NbExp=3; IntAct=EBI-8643161, EBI-748171;
CC Q9NX04; Q8WUE5: CT55; NbExp=3; IntAct=EBI-8643161, EBI-6873363;
CC Q9NX04; P78358: CTAG1B; NbExp=3; IntAct=EBI-8643161, EBI-1188472;
CC Q9NX04; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-8643161, EBI-11988027;
CC Q9NX04; Q16610: ECM1; NbExp=3; IntAct=EBI-8643161, EBI-947964;
CC Q9NX04; Q9BQ95: ECSIT; NbExp=3; IntAct=EBI-8643161, EBI-712452;
CC Q9NX04; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-8643161, EBI-19153639;
CC Q9NX04; B7ZLH0: FAM22F; NbExp=3; IntAct=EBI-8643161, EBI-10220102;
CC Q9NX04; Q9NVL1-2: FAM86C1P; NbExp=3; IntAct=EBI-8643161, EBI-12845222;
CC Q9NX04; Q9C0B1-2: FTO; NbExp=3; IntAct=EBI-8643161, EBI-18138793;
CC Q9NX04; Q7L5D6: GET4; NbExp=3; IntAct=EBI-8643161, EBI-711823;
CC Q9NX04; O75420: GIGYF1; NbExp=3; IntAct=EBI-8643161, EBI-947774;
CC Q9NX04; Q08379: GOLGA2; NbExp=3; IntAct=EBI-8643161, EBI-618309;
CC Q9NX04; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-8643161, EBI-11163335;
CC Q9NX04; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-8643161, EBI-5916454;
CC Q9NX04; Q9UBX0: HESX1; NbExp=3; IntAct=EBI-8643161, EBI-8470369;
CC Q9NX04; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-8643161, EBI-10961706;
CC Q9NX04; P31273: HOXC8; NbExp=3; IntAct=EBI-8643161, EBI-1752118;
CC Q9NX04; Q8IYA8: IHO1; NbExp=6; IntAct=EBI-8643161, EBI-8638439;
CC Q9NX04; Q13422: IKZF1; NbExp=3; IntAct=EBI-8643161, EBI-745305;
CC Q9NX04; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-8643161, EBI-11522367;
CC Q9NX04; Q9UKT9: IKZF3; NbExp=6; IntAct=EBI-8643161, EBI-747204;
CC Q9NX04; Q96EL1: INKA1; NbExp=3; IntAct=EBI-8643161, EBI-10285157;
CC Q9NX04; Q9BW62: KATNAL1; NbExp=6; IntAct=EBI-8643161, EBI-743591;
CC Q9NX04; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-8643161, EBI-2805604;
CC Q9NX04; Q9BVG8: KIFC3; NbExp=4; IntAct=EBI-8643161, EBI-2125614;
CC Q9NX04; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-8643161, EBI-14069005;
CC Q9NX04; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-8643161, EBI-2796400;
CC Q9NX04; A1A4E9: KRT13; NbExp=3; IntAct=EBI-8643161, EBI-10171552;
CC Q9NX04; P08779: KRT16; NbExp=3; IntAct=EBI-8643161, EBI-356410;
CC Q9NX04; P05783: KRT18; NbExp=3; IntAct=EBI-8643161, EBI-297888;
CC Q9NX04; P08727: KRT19; NbExp=6; IntAct=EBI-8643161, EBI-742756;
CC Q9NX04; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-8643161, EBI-2952736;
CC Q9NX04; Q15323: KRT31; NbExp=6; IntAct=EBI-8643161, EBI-948001;
CC Q9NX04; Q92764: KRT35; NbExp=3; IntAct=EBI-8643161, EBI-1058674;
CC Q9NX04; Q6A162: KRT40; NbExp=3; IntAct=EBI-8643161, EBI-10171697;
CC Q9NX04; O95678: KRT75; NbExp=3; IntAct=EBI-8643161, EBI-2949715;
CC Q9NX04; Q01546: KRT76; NbExp=3; IntAct=EBI-8643161, EBI-2952745;
CC Q9NX04; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-8643161, EBI-11999246;
CC Q9NX04; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-8643161, EBI-10241252;
CC Q9NX04; O95751: LDOC1; NbExp=3; IntAct=EBI-8643161, EBI-740738;
CC Q9NX04; P25791-3: LMO2; NbExp=5; IntAct=EBI-8643161, EBI-11959475;
CC Q9NX04; Q9BRK4: LZTS2; NbExp=6; IntAct=EBI-8643161, EBI-741037;
CC Q9NX04; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-8643161, EBI-12516603;
CC Q9NX04; O15151: MDM4; NbExp=3; IntAct=EBI-8643161, EBI-398437;
CC Q9NX04; A8MW99: MEI4; NbExp=3; IntAct=EBI-8643161, EBI-19944212;
CC Q9NX04; P50221: MEOX1; NbExp=3; IntAct=EBI-8643161, EBI-2864512;
CC Q9NX04; P50222: MEOX2; NbExp=3; IntAct=EBI-8643161, EBI-748397;
CC Q9NX04; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-8643161, EBI-16439278;
CC Q9NX04; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-8643161, EBI-2548751;
CC Q9NX04; Q9H000: MKRN2; NbExp=3; IntAct=EBI-8643161, EBI-2341005;
CC Q9NX04; Q9H019: MTFR1L; NbExp=3; IntAct=EBI-8643161, EBI-2824497;
CC Q9NX04; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-8643161, EBI-742948;
CC Q9NX04; P17568: NDUFB7; NbExp=3; IntAct=EBI-8643161, EBI-1246238;
CC Q9NX04; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-8643161, EBI-10172876;
CC Q9NX04; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-8643161, EBI-10271199;
CC Q9NX04; O00746: NME4; NbExp=3; IntAct=EBI-8643161, EBI-744871;
CC Q9NX04; Q7Z3B4: NUP54; NbExp=5; IntAct=EBI-8643161, EBI-741048;
CC Q9NX04; A6NGQ2: OOEP; NbExp=3; IntAct=EBI-8643161, EBI-18583589;
CC Q9NX04; Q02548: PAX5; NbExp=3; IntAct=EBI-8643161, EBI-296331;
CC Q9NX04; P26367: PAX6; NbExp=3; IntAct=EBI-8643161, EBI-747278;
CC Q9NX04; P23759-2: PAX7; NbExp=3; IntAct=EBI-8643161, EBI-12859446;
CC Q9NX04; Q9BYU1: PBX4; NbExp=5; IntAct=EBI-8643161, EBI-10302990;
CC Q9NX04; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-8643161, EBI-1105124;
CC Q9NX04; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-8643161, EBI-9640281;
CC Q9NX04; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-8643161, EBI-713786;
CC Q9NX04; O00444: PLK4; NbExp=3; IntAct=EBI-8643161, EBI-746202;
CC Q9NX04; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-8643161, EBI-302345;
CC Q9NX04; P01189: POMC; NbExp=3; IntAct=EBI-8643161, EBI-12219503;
CC Q9NX04; P78424: POU6F2; NbExp=3; IntAct=EBI-8643161, EBI-12029004;
CC Q9NX04; Q9BZL4: PPP1R12C; NbExp=3; IntAct=EBI-8643161, EBI-721802;
CC Q9NX04; Q9BZL4-5: PPP1R12C; NbExp=3; IntAct=EBI-8643161, EBI-10289057;
CC Q9NX04; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-8643161, EBI-11320284;
CC Q9NX04; O14744: PRMT5; NbExp=3; IntAct=EBI-8643161, EBI-351098;
CC Q9NX04; P28070: PSMB4; NbExp=3; IntAct=EBI-8643161, EBI-603350;
CC Q9NX04; Q08623: PUDP; NbExp=3; IntAct=EBI-8643161, EBI-12807240;
CC Q9NX04; Q04864: REL; NbExp=3; IntAct=EBI-8643161, EBI-307352;
CC Q9NX04; Q04864-2: REL; NbExp=3; IntAct=EBI-8643161, EBI-10829018;
CC Q9NX04; Q6NUQ1: RINT1; NbExp=6; IntAct=EBI-8643161, EBI-726876;
CC Q9NX04; Q5VTR2: RNF20; NbExp=3; IntAct=EBI-8643161, EBI-2372238;
CC Q9NX04; Q9H4P4: RNF41; NbExp=6; IntAct=EBI-8643161, EBI-2130266;
CC Q9NX04; Q9UNE2: RPH3AL; NbExp=3; IntAct=EBI-8643161, EBI-2855824;
CC Q9NX04; Q9BVN2: RUSC1; NbExp=5; IntAct=EBI-8643161, EBI-6257312;
CC Q9NX04; Q86UD0: SAPCD2; NbExp=5; IntAct=EBI-8643161, EBI-2561646;
CC Q9NX04; O00560: SDCBP; NbExp=3; IntAct=EBI-8643161, EBI-727004;
CC Q9NX04; Q9UHV2: SERTAD1; NbExp=3; IntAct=EBI-8643161, EBI-748601;
CC Q9NX04; Q14140: SERTAD2; NbExp=3; IntAct=EBI-8643161, EBI-2822051;
CC Q9NX04; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-8643161, EBI-10269374;
CC Q9NX04; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-8643161, EBI-358489;
CC Q9NX04; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-8643161, EBI-10269322;
CC Q9NX04; O14544: SOCS6; NbExp=3; IntAct=EBI-8643161, EBI-3929549;
CC Q9NX04; O60504: SORBS3; NbExp=3; IntAct=EBI-8643161, EBI-741237;
CC Q9NX04; Q96R06: SPAG5; NbExp=3; IntAct=EBI-8643161, EBI-413317;
CC Q9NX04; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-8643161, EBI-725557;
CC Q9NX04; Q9H668: STN1; NbExp=5; IntAct=EBI-8643161, EBI-746930;
CC Q9NX04; O75558: STX11; NbExp=6; IntAct=EBI-8643161, EBI-714135;
CC Q9NX04; O75478: TADA2A; NbExp=6; IntAct=EBI-8643161, EBI-742268;
CC Q9NX04; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-8643161, EBI-745958;
CC Q9NX04; Q99081: TCF12; NbExp=3; IntAct=EBI-8643161, EBI-722877;
CC Q9NX04; P15884: TCF4; NbExp=3; IntAct=EBI-8643161, EBI-533224;
CC Q9NX04; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-8643161, EBI-750487;
CC Q9NX04; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-8643161, EBI-11139477;
CC Q9NX04; Q9UBB9: TFIP11; NbExp=6; IntAct=EBI-8643161, EBI-1105213;
CC Q9NX04; Q08117: TLE5; NbExp=3; IntAct=EBI-8643161, EBI-717810;
CC Q9NX04; Q08117-2: TLE5; NbExp=3; IntAct=EBI-8643161, EBI-11741437;
CC Q9NX04; P48788: TNNI2; NbExp=3; IntAct=EBI-8643161, EBI-7746394;
CC Q9NX04; Q13077: TRAF1; NbExp=6; IntAct=EBI-8643161, EBI-359224;
CC Q9NX04; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-8643161, EBI-5235829;
CC Q9NX04; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-8643161, EBI-2130429;
CC Q9NX04; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-8643161, EBI-10241197;
CC Q9NX04; Q9H892-2: TTC12; NbExp=3; IntAct=EBI-8643161, EBI-10274410;
CC Q9NX04; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-8643161, EBI-9090990;
CC Q9NX04; Q6PF05: TTC23L; NbExp=3; IntAct=EBI-8643161, EBI-8656864;
CC Q9NX04; Q8TAS1-2: UHMK1; NbExp=3; IntAct=EBI-8643161, EBI-12157345;
CC Q9NX04; Q495M9: USH1G; NbExp=3; IntAct=EBI-8643161, EBI-8601749;
CC Q9NX04; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-8643161, EBI-739895;
CC Q9NX04; P61758: VBP1; NbExp=3; IntAct=EBI-8643161, EBI-357430;
CC Q9NX04; Q99990: VGLL1; NbExp=3; IntAct=EBI-8643161, EBI-11983165;
CC Q9NX04; Q8N1B4: VPS52; NbExp=6; IntAct=EBI-8643161, EBI-2799833;
CC Q9NX04; O96006: ZBED1; NbExp=7; IntAct=EBI-8643161, EBI-740037;
CC Q9NX04; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-8643161, EBI-12287587;
CC Q9NX04; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-8643161, EBI-7850213;
CC Q9NX04; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-8643161, EBI-12030590;
CC Q9NX04; P17021: ZNF17; NbExp=3; IntAct=EBI-8643161, EBI-1105334;
CC Q9NX04; P17024: ZNF20; NbExp=3; IntAct=EBI-8643161, EBI-717634;
CC Q9NX04; Q8TD17: ZNF398; NbExp=4; IntAct=EBI-8643161, EBI-8643207;
CC Q9NX04; Q8TAQ5: ZNF420; NbExp=3; IntAct=EBI-8643161, EBI-3923307;
CC Q9NX04; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-8643161, EBI-4395732;
CC Q9NX04; O15535: ZSCAN9; NbExp=3; IntAct=EBI-8643161, EBI-751531;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22548824}. Cytoplasm
CC {ECO:0000269|PubMed:22548824}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NX04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NX04-2; Sequence=VSP_022733, VSP_022734;
CC -!- PTM: Phosphorylated on serines by CK2 kinase.
CC {ECO:0000269|PubMed:22548824}.
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DR EMBL; AK000515; BAA91221.1; -; mRNA.
DR EMBL; CH471059; EAX07327.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07329.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07330.1; -; Genomic_DNA.
DR EMBL; BC018109; AAH18109.1; -; mRNA.
DR EMBL; BC063843; AAH63843.1; -; mRNA.
DR CCDS; CCDS423.1; -. [Q9NX04-1]
DR RefSeq; NP_001289959.1; NM_001303030.1.
DR RefSeq; NP_001289960.1; NM_001303031.1.
DR RefSeq; NP_060320.1; NM_017850.2. [Q9NX04-1]
DR RefSeq; XP_016857035.1; XM_017001546.1.
DR RefSeq; XP_016857036.1; XM_017001547.1.
DR RefSeq; XP_016857040.1; XM_017001551.1.
DR RefSeq; XP_016857041.1; XM_017001552.1.
DR RefSeq; XP_016857042.1; XM_017001553.1.
DR RefSeq; XP_016857043.1; XM_017001554.1.
DR RefSeq; XP_016857044.1; XM_017001555.1.
DR RefSeq; XP_016857045.1; XM_017001556.1. [Q9NX04-1]
DR AlphaFoldDB; Q9NX04; -.
DR SMR; Q9NX04; -.
DR BioGRID; 120293; 153.
DR IntAct; Q9NX04; 144.
DR MINT; Q9NX04; -.
DR STRING; 9606.ENSP00000350704; -.
DR iPTMnet; Q9NX04; -.
DR PhosphoSitePlus; Q9NX04; -.
DR BioMuta; C1orf109; -.
DR DMDM; 74761780; -.
DR EPD; Q9NX04; -.
DR jPOST; Q9NX04; -.
DR MassIVE; Q9NX04; -.
DR MaxQB; Q9NX04; -.
DR PaxDb; Q9NX04; -.
DR PeptideAtlas; Q9NX04; -.
DR PRIDE; Q9NX04; -.
DR ProteomicsDB; 83013; -. [Q9NX04-1]
DR ProteomicsDB; 83014; -. [Q9NX04-2]
DR Antibodypedia; 17567; 50 antibodies from 9 providers.
DR DNASU; 54955; -.
DR Ensembl; ENST00000358011.8; ENSP00000350704.4; ENSG00000116922.15. [Q9NX04-1]
DR Ensembl; ENST00000464085.5; ENSP00000477159.1; ENSG00000116922.15. [Q9NX04-1]
DR Ensembl; ENST00000486637.2; ENSP00000476779.2; ENSG00000116922.15. [Q9NX04-1]
DR Ensembl; ENST00000494120.1; ENSP00000477273.1; ENSG00000116922.15. [Q9NX04-2]
DR GeneID; 54955; -.
DR KEGG; hsa:54955; -.
DR MANE-Select; ENST00000486637.2; ENSP00000476779.2; NM_001350770.2; NP_001337699.1.
DR UCSC; uc001cbn.4; human. [Q9NX04-1]
DR CTD; 54955; -.
DR DisGeNET; 54955; -.
DR GeneCards; C1orf109; -.
DR HGNC; HGNC:26039; C1orf109.
DR HPA; ENSG00000116922; Low tissue specificity.
DR MIM; 614799; gene.
DR neXtProt; NX_Q9NX04; -.
DR OpenTargets; ENSG00000116922; -.
DR PharmGKB; PA142672493; -.
DR VEuPathDB; HostDB:ENSG00000116922; -.
DR eggNOG; ENOG502S0VU; Eukaryota.
DR GeneTree; ENSGT00390000008551; -.
DR HOGENOM; CLU_111850_0_0_1; -.
DR InParanoid; Q9NX04; -.
DR OMA; SHVEQVF; -.
DR OrthoDB; 1504674at2759; -.
DR PhylomeDB; Q9NX04; -.
DR TreeFam; TF332524; -.
DR PathwayCommons; Q9NX04; -.
DR SignaLink; Q9NX04; -.
DR BioGRID-ORCS; 54955; 593 hits in 1058 CRISPR screens.
DR ChiTaRS; C1orf109; human.
DR GeneWiki; C1orf109_(gene); -.
DR GenomeRNAi; 54955; -.
DR Pharos; Q9NX04; Tdark.
DR PRO; PR:Q9NX04; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NX04; protein.
DR Bgee; ENSG00000116922; Expressed in ventricular zone and 180 other tissues.
DR ExpressionAtlas; Q9NX04; baseline and differential.
DR Genevisible; Q9NX04; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IDA:UniProtKB.
DR InterPro; IPR029159; CK2S.
DR PANTHER; PTHR16234; PTHR16234; 1.
DR Pfam; PF15011; CK2S; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Ribosome biogenesis.
FT CHAIN 1..203
FT /note="Ribosome biogenesis protein C1orf109"
FT /id="PRO_0000274382"
FT VAR_SEQ 75..113
FT /note="RKQLVAGDIVLDKLGERLAILLKVRDMVSSHVERVFQIY -> QPSSSRCET
FT WSAAMWSECFRSMSNTQTQLALMLSCSLQQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022733"
FT VAR_SEQ 114..203
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022734"
FT MUTAGEN 104
FT /note="S->A: Abolishes phosphorylation by CK2 kinase; when
FT associated with A-134 and A-182."
FT /evidence="ECO:0000269|PubMed:22548824"
FT MUTAGEN 134
FT /note="S->A: Abolishes phosphorylation by CK2 kinase; when
FT associated with A-104 and A-182."
FT /evidence="ECO:0000269|PubMed:22548824"
FT MUTAGEN 182
FT /note="S->A: Abolishes phosphorylation by CK2 kinase; when
FT associated with A-104 and A-134."
FT /evidence="ECO:0000269|PubMed:22548824"
SQ SEQUENCE 203 AA; 23373 MW; CBD3883CB1A2C281 CRC64;
MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ AAQNLRFEDV
PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD MVSSHVERVF QIYEQHADTV
GIDAVLQPSA VSPSVADMLE WLQDIERHYR KSYLKRKYLL SSIQWGDLAN IQALPKAWDR
ISKDEHQDLV QDILLNVSFF LEE
