ID   CA109_DANRE             Reviewed;         202 AA.
AC   Q8JHH5; B5DDC7; Q504J6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 3.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ribosome biogenesis protein C1orf109 homolog {ECO:0000305};
GN   ORFNames=zgc:109790;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the cytoplasmic maturation steps of pre-60S
CC       ribosomal particles by promoting the release of shuttling protein
CC       RSL24D1/RLP24 from the pre-ribosomal particles (By similarity). Plays
CC       an essential role in early embryonic development (PubMed:12006978).
CC       {ECO:0000250|UniProtKB:Q9NX04, ECO:0000269|PubMed:12006978}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NX04}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9NX04}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show defects in branchial arch and
CC       ceratohyal development. {ECO:0000269|PubMed:12006978}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM34665.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF506221; AAM34665.1; ALT_INIT; mRNA.
DR   EMBL; BC094993; AAH94993.1; -; mRNA.
DR   EMBL; BC164043; AAI64043.1; -; mRNA.
DR   RefSeq; NP_775376.1; NM_173269.1.
DR   AlphaFoldDB; Q8JHH5; -.
DR   STRING; 7955.ENSDARP00000025246; -.
DR   PaxDb; Q8JHH5; -.
DR   DNASU; 286778; -.
DR   GeneID; 286778; -.
DR   KEGG; dre:286778; -.
DR   CTD; 286778; -.
DR   ZFIN; ZDB-GENE-021219-1; c19h1orf109.
DR   eggNOG; ENOG502S0VU; Eukaryota.
DR   InParanoid; Q8JHH5; -.
DR   OrthoDB; 1504674at2759; -.
DR   PhylomeDB; Q8JHH5; -.
DR   PRO; PR:Q8JHH5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR029159; CK2S.
DR   PANTHER; PTHR16234; PTHR16234; 1.
DR   Pfam; PF15011; CK2S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..202
FT                   /note="Ribosome biogenesis protein C1orf109 homolog"
FT                   /id="PRO_0000274384"
FT   CONFLICT        46
FT                   /note="P -> L (in Ref. 1; AAM34665)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="W -> R (in Ref. 1; AAM34665)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        130
FT                   /note="C -> S (in Ref. 1; AAM34665)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        165
FT                   /note="D -> G (in Ref. 1; AAM34665)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   202 AA;  22619 MW;  E95FE688E3BBCB1E CRC64;
     MPGSALLSLQ QELRRGFEAL KAAKDTFDGG HAECQELVSS LGNLAPQLKA LKQVQISETP
     LSGFPCLQQR LHYKLSLAVD ALLAKLAEKM AALQKVWDAF AQQVFTVVQL YEKNTDALDI
     SVCVSRSAVC PSVSDMLEWL QDADRYYRLQ LMQSRLLLQT LTPTDLTSME TAPNRWRSVR
     SARQEERIAD ALCQVSIFLE TE