CA105_HUMAN
ID CA105_HUMAN Reviewed; 183 AA.
AC O95561; Q8IY02;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Uncharacterized protein C1orf105;
GN Name=C1orf105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Rhodes S.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-137.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O95561; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10191951, EBI-744099;
CC O95561; P45984: MAPK9; NbExp=5; IntAct=EBI-10191951, EBI-713568;
CC O95561; O15160: POLR1C; NbExp=3; IntAct=EBI-10191951, EBI-1055079;
CC O95561; P25788: PSMA3; NbExp=3; IntAct=EBI-10191951, EBI-348380;
CC O95561; P0C264: SBK3; NbExp=3; IntAct=EBI-10191951, EBI-17181801;
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DR EMBL; AL035295; CAA22895.1; -; mRNA.
DR EMBL; Z97195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038410; AAH38410.1; -; mRNA.
DR CCDS; CCDS1301.1; -.
DR RefSeq; NP_640333.3; NM_139240.3.
DR AlphaFoldDB; O95561; -.
DR SMR; O95561; -.
DR BioGRID; 124939; 10.
DR IntAct; O95561; 7.
DR STRING; 9606.ENSP00000356700; -.
DR iPTMnet; O95561; -.
DR PhosphoSitePlus; O95561; -.
DR BioMuta; C1orf105; -.
DR PaxDb; O95561; -.
DR PRIDE; O95561; -.
DR ProteomicsDB; 50940; -.
DR Antibodypedia; 49838; 85 antibodies from 13 providers.
DR DNASU; 92346; -.
DR Ensembl; ENST00000367727.9; ENSP00000356700.4; ENSG00000180999.11.
DR GeneID; 92346; -.
DR KEGG; hsa:92346; -.
DR MANE-Select; ENST00000367727.9; ENSP00000356700.4; NM_139240.4; NP_640333.3.
DR UCSC; uc001gik.3; human.
DR CTD; 92346; -.
DR DisGeNET; 92346; -.
DR GeneCards; C1orf105; -.
DR HGNC; HGNC:29591; C1orf105.
DR HPA; ENSG00000180999; Tissue enhanced (heart muscle, testis).
DR neXtProt; NX_O95561; -.
DR OpenTargets; ENSG00000180999; -.
DR PharmGKB; PA142672489; -.
DR VEuPathDB; HostDB:ENSG00000180999; -.
DR eggNOG; ENOG502TDU3; Eukaryota.
DR GeneTree; ENSGT00390000015231; -.
DR HOGENOM; CLU_1474736_0_0_1; -.
DR InParanoid; O95561; -.
DR OMA; DKIPWFS; -.
DR OrthoDB; 1302630at2759; -.
DR PhylomeDB; O95561; -.
DR TreeFam; TF336911; -.
DR PathwayCommons; O95561; -.
DR SignaLink; O95561; -.
DR BioGRID-ORCS; 92346; 10 hits in 1038 CRISPR screens.
DR ChiTaRS; C1orf105; human.
DR GenomeRNAi; 92346; -.
DR Pharos; O95561; Tdark.
DR PRO; PR:O95561; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O95561; protein.
DR Bgee; ENSG00000180999; Expressed in sperm and 103 other tissues.
DR ExpressionAtlas; O95561; baseline and differential.
DR Genevisible; O95561; HS.
DR InterPro; IPR027845; DUF4548.
DR PANTHER; PTHR39410; PTHR39410; 1.
DR Pfam; PF15081; DUF4548; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..183
FT /note="Uncharacterized protein C1orf105"
FT /id="PRO_0000251727"
FT VARIANT 97
FT /note="M -> V (in dbSNP:rs16844498)"
FT /id="VAR_027710"
FT VARIANT 137
FT /note="S -> N (in dbSNP:rs1129942)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027711"
SQ SEQUENCE 183 AA; 21209 MW; 665168CBB7409A30 CRC64;
MEKRELKASV PKFDKIPWLS EASLVNKPLV LSLPRRYPHT SATFLTSSKK NMNLPILFQV
PDVLSKARRN QCDSMLLRNQ QLCSTCQEMK MVQPRTMKIP DDPKASFENC MSYRMSLHQP
KFQTTPEPFH DDIPTESIHY RLPILGPRTA VFHGLLTEAY KTLKERQRSS LPRKEPIGKT
TRQ
