CA087_HUMAN
ID CA087_HUMAN Reviewed; 546 AA.
AC Q8N0U7; Q6ZU07; Q8IVS0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Uncharacterized protein C1orf87;
GN Name=C1orf87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLU-403.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-151.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N0U7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N0U7-2; Sequence=VSP_024541, VSP_024542;
CC Name=3;
CC IsoId=Q8N0U7-3; Sequence=VSP_024540;
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DR EMBL; AK126061; BAC86420.1; -; mRNA.
DR EMBL; BC027878; AAH27878.1; -; mRNA.
DR EMBL; BC042203; AAH42203.1; -; mRNA.
DR CCDS; CCDS614.1; -. [Q8N0U7-1]
DR RefSeq; NP_689590.1; NM_152377.2. [Q8N0U7-1]
DR AlphaFoldDB; Q8N0U7; -.
DR BioGRID; 126083; 22.
DR IntAct; Q8N0U7; 17.
DR STRING; 9606.ENSP00000360244; -.
DR iPTMnet; Q8N0U7; -.
DR PhosphoSitePlus; Q8N0U7; -.
DR BioMuta; C1orf87; -.
DR DMDM; 74759752; -.
DR MassIVE; Q8N0U7; -.
DR PaxDb; Q8N0U7; -.
DR PeptideAtlas; Q8N0U7; -.
DR PRIDE; Q8N0U7; -.
DR ProteomicsDB; 71460; -. [Q8N0U7-1]
DR ProteomicsDB; 71461; -. [Q8N0U7-2]
DR ProteomicsDB; 71462; -. [Q8N0U7-3]
DR Antibodypedia; 33284; 80 antibodies from 14 providers.
DR DNASU; 127795; -.
DR Ensembl; ENST00000371201.3; ENSP00000360244.3; ENSG00000162598.13. [Q8N0U7-1]
DR GeneID; 127795; -.
DR KEGG; hsa:127795; -.
DR MANE-Select; ENST00000371201.3; ENSP00000360244.3; NM_152377.3; NP_689590.1.
DR UCSC; uc001czs.3; human. [Q8N0U7-1]
DR CTD; 127795; -.
DR DisGeNET; 127795; -.
DR GeneCards; C1orf87; -.
DR HGNC; HGNC:28547; C1orf87.
DR HPA; ENSG00000162598; Group enriched (brain, fallopian tube).
DR MIM; 618860; gene.
DR neXtProt; NX_Q8N0U7; -.
DR OpenTargets; ENSG00000162598; -.
DR PharmGKB; PA142672471; -.
DR VEuPathDB; HostDB:ENSG00000162598; -.
DR eggNOG; ENOG502RIAR; Eukaryota.
DR GeneTree; ENSGT00390000008678; -.
DR HOGENOM; CLU_040182_0_0_1; -.
DR InParanoid; Q8N0U7; -.
DR OMA; TIKILCQ; -.
DR OrthoDB; 950399at2759; -.
DR PhylomeDB; Q8N0U7; -.
DR TreeFam; TF338576; -.
DR PathwayCommons; Q8N0U7; -.
DR SignaLink; Q8N0U7; -.
DR BioGRID-ORCS; 127795; 19 hits in 1056 CRISPR screens.
DR ChiTaRS; C1orf87; human.
DR GenomeRNAi; 127795; -.
DR Pharos; Q8N0U7; Tbio.
DR PRO; PR:Q8N0U7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N0U7; protein.
DR Bgee; ENSG00000162598; Expressed in bronchial epithelial cell and 96 other tissues.
DR ExpressionAtlas; Q8N0U7; baseline and differential.
DR Genevisible; Q8N0U7; HS.
DR InterPro; IPR040774; DUF5580.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR PANTHER; PTHR34830; PTHR34830; 1.
DR Pfam; PF17743; DUF5580; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..546
FT /note="Uncharacterized protein C1orf87"
FT /id="PRO_0000284489"
FT REGION 37..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..408
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024540"
FT VAR_SEQ 1..366
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024541"
FT VAR_SEQ 367..397
FT /note="QDLGYQNEIKWQNFVEMLTRASSDLLSDLPT -> MSRGCSSDLRFHTWLGL
FT RMLKNIIAVALLML (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024542"
FT VARIANT 151
FT /note="Q -> E (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035493"
FT VARIANT 185
FT /note="L -> V (in dbSNP:rs12737449)"
FT /id="VAR_031745"
FT VARIANT 301
FT /note="N -> D (in dbSNP:rs17120025)"
FT /id="VAR_031746"
FT VARIANT 403
FT /note="K -> E (in dbSNP:rs626251)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_031747"
FT VARIANT 406
FT /note="A -> P (in dbSNP:rs35260089)"
FT /id="VAR_031748"
SQ SEQUENCE 546 AA; 62035 MW; DDC8452AFC30FDA2 CRC64;
MSSAWKTPRG SDAMPEIMVK IIGSKHFQYL VEKPKIKEND SLKTETQTMH QKPMTDNARQ
MSRDTPVPIN FTDQQTTDNP DDVKEKKHPE NNQKSENNQK LLTGANSSRF LDGNIPSQAN
VHCSSVPTGD QSLSYVHGIP RRKLRDWSLE QMVRGSSDQP EDIGQSPSGT TNEDAFLLAL
VRRELKSRPL SSNLLEKLQK ELKILDPISS GFLLQSQLSR LFLKHEVPLQ LPTVKILCQR
FSKRGSPEMV NYEKLLWFLN SAASDYPQQN KAAADLRKTE SHGTHSQSTP PQHSSSQPEV
NRSLLEILKM ALRTTNGRLN IDNLNLSFRK EDRSFSGCLP LPKVRAICGK HGLYLTLSLL
ETLLNHQDLG YQNEIKWQNF VEMLTRASSD LLSDLPTGKN EKKAPAPPME PEVPEMSQSK
TEHMKTPEEE LQPESSPAET SACKDPLKPL KIRPVSQPFV NPAVKNKAEE CETWIDRFRK
LENALYLCDL SNTGVLEKER ARRLIHNYNL IYNLSLSPQK IDQALRRFRS GENMLLEPAL
RYLKEL
