CA074_HUMAN
ID CA074_HUMAN Reviewed; 269 AA.
AC Q96LT6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=UPF0739 protein C1orf74;
GN Name=C1orf74;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96LT6; Q9BZE7: C22orf23; NbExp=3; IntAct=EBI-12049899, EBI-10303102;
CC Q96LT6; P24592: IGFBP6; NbExp=3; IntAct=EBI-12049899, EBI-947015;
CC Q96LT6; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-12049899, EBI-12516603;
CC Q96LT6; Q04864-2: REL; NbExp=3; IntAct=EBI-12049899, EBI-10829018;
CC Q96LT6; Q969V4: TEKT1; NbExp=3; IntAct=EBI-12049899, EBI-10180409;
CC Q96LT6; Q9GZV5: WWTR1; NbExp=3; IntAct=EBI-12049899, EBI-747743;
CC -!- SIMILARITY: Belongs to the UPF0739 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK057807; BAB71584.1; -; mRNA.
DR EMBL; AL022398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039719; AAH39719.1; -; mRNA.
DR CCDS; CCDS1491.1; -.
DR RefSeq; NP_689698.1; NM_152485.3.
DR AlphaFoldDB; Q96LT6; -.
DR BioGRID; 127141; 17.
DR IntAct; Q96LT6; 6.
DR STRING; 9606.ENSP00000294811; -.
DR GlyGen; Q96LT6; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; C1orf74; -.
DR EPD; Q96LT6; -.
DR jPOST; Q96LT6; -.
DR MassIVE; Q96LT6; -.
DR PaxDb; Q96LT6; -.
DR PeptideAtlas; Q96LT6; -.
DR PRIDE; Q96LT6; -.
DR ProteomicsDB; 77247; -.
DR Antibodypedia; 34597; 63 antibodies from 15 providers.
DR DNASU; 148304; -.
DR Ensembl; ENST00000294811.2; ENSP00000294811.1; ENSG00000162757.4.
DR GeneID; 148304; -.
DR KEGG; hsa:148304; -.
DR MANE-Select; ENST00000294811.2; ENSP00000294811.1; NM_152485.4; NP_689698.1.
DR UCSC; uc001hhp.2; human.
DR CTD; 148304; -.
DR DisGeNET; 148304; -.
DR GeneCards; C1orf74; -.
DR HGNC; HGNC:26319; C1orf74.
DR HPA; ENSG00000162757; Low tissue specificity.
DR neXtProt; NX_Q96LT6; -.
DR OpenTargets; ENSG00000162757; -.
DR PharmGKB; PA142672523; -.
DR VEuPathDB; HostDB:ENSG00000162757; -.
DR eggNOG; ENOG502RZ46; Eukaryota.
DR GeneTree; ENSGT00390000002240; -.
DR HOGENOM; CLU_1156081_0_0_1; -.
DR InParanoid; Q96LT6; -.
DR OMA; CCLYSFS; -.
DR OrthoDB; 1509113at2759; -.
DR PhylomeDB; Q96LT6; -.
DR TreeFam; TF328609; -.
DR PathwayCommons; Q96LT6; -.
DR SignaLink; Q96LT6; -.
DR BioGRID-ORCS; 148304; 51 hits in 992 CRISPR screens.
DR ChiTaRS; C1orf74; human.
DR GenomeRNAi; 148304; -.
DR Pharos; Q96LT6; Tdark.
DR PRO; PR:Q96LT6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96LT6; protein.
DR Bgee; ENSG00000162757; Expressed in granulocyte and 128 other tissues.
DR ExpressionAtlas; Q96LT6; baseline and differential.
DR Genevisible; Q96LT6; HS.
DR InterPro; IPR027850; DUF4504.
DR PANTHER; PTHR31366; PTHR31366; 1.
DR Pfam; PF14953; DUF4504; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..269
FT /note="UPF0739 protein C1orf74"
FT /id="PRO_0000271092"
FT VARIANT 146
FT /note="L -> F (in dbSNP:rs7550857)"
FT /id="VAR_050701"
SQ SEQUENCE 269 AA; 29561 MW; 12E2D58AA1E2F617 CRC64;
MLLLDLMSSP SPQLLVAAAQ QTLGMGKRRS PPQAICLHLA GEVLAVARGL KPAVLYDCNC
AGASELQSYL EELKGLGFLT FGLHILEIGE NSLIVSPEHV CQHLEQVLLG TIAFVDVSSC
QRHPSVCSLD QLQDLKALVA EIITHLQGLQ RDLSLAVSYS RLHSSDWNLC TVFGILLGYP
VPYTFHLNQG DDNCLALTPL RVFTARISWL LGQPPILLYS FSVPESLFPG LRDILNTWEK
DLRTRFRTQN DFADLSISSE IVTLPAVAL
