ID   C9L_VACCW               Reviewed;         634 AA.
AC   P17372; Q80HY5;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   23-FEB-2022, entry version 85.
DE   RecName: Full=Ankyrin repeat protein C9L;
GN   OrderedLocusNames=VACWR019; ORFNames=C9L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST CUL1; SKP1; COPS7A AND COPS7B.
RX   PubMed=29444943; DOI=10.1128/jvi.00053-18;
RA   Liu R., Moss B.;
RT   "Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified
RT   Antagonist of the Type I Interferon-Induced Antiviral State.";
RL   J. Virol. 92:0-0(2018).
CC   -!- FUNCTION: Plays a role in the inhibition of host immune repsonse by
CC       counteracting the action of interferons on early events in the viral
CC       replication cycle. {ECO:0000269|PubMed:29444943}.
CC   -!- SUBUNIT: Interacts with components of host SCF complex CUL1 and SKP1
CC       and components of the cullin deneddylation/COP9 signalosome complex
CC       subunits COPS7A and COPS7B. {ECO:0000269|PubMed:29444943}.
CC   -!- SIMILARITY: Belongs to the vaccinia virus protein C9L protein family.
CC       {ECO:0000305}.
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DR   EMBL; M22812; AAA69599.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89298.1; -; Genomic_DNA.
DR   PIR; H31829; WZVZA8.
DR   RefSeq; YP_232901.1; NC_006998.1.
DR   SMR; P17372; -.
DR   DNASU; 3707634; -.
DR   GeneID; 3707634; -.
DR   KEGG; vg:3707634; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IDA:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   SMART; SM00248; ANK; 7.
DR   SMART; SM00025; Pumilio; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Repeat; Viral immunoevasion.
FT   CHAIN           1..634
FT                   /note="Ankyrin repeat protein C9L"
FT                   /id="PRO_0000067094"
FT   REPEAT          36..69
FT                   /note="ANK 1"
FT   REPEAT          70..100
FT                   /note="ANK 2"
FT   REPEAT          103..134
FT                   /note="ANK 3"
FT   REPEAT          175..211
FT                   /note="ANK 4"
FT   REPEAT          307..337
FT                   /note="ANK 5"
FT   REPEAT          412..441
FT                   /note="ANK 6"
FT   CONFLICT        487..488
FT                   /note="KT -> FS (in Ref. 1; AAA69599)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   634 AA;  74680 MW;  9CCE1C5B509EE5BB CRC64;
     MVNDKILYDS CKTFNIDASS AQSLIESGAN PLYEYDGETP LKAYVTKKNN NIKNDVVILL
     LSSVDYKNIN DFDIFEYLCS DNIDIDLLKL LISKGIEINS IKNGINIVEK YATTSNPNVD
     VFKLLLDKGI PTCSNIQYGY KIKIEQIRRA GEYYNWDDEL DDYDYDYTTD YDDRMGKTVL
     YYYIITRSQD GYATSLDVIN YLISHKKEMR YYTYREHTTL YYYLDKCDIK REIFDALFDS
     NYSGHELMNI LSNYLRKQFR KKNHKIDNYI VDQLLFDRDT FYILELCNSL RNNILISTIL
     KRYTDSIQDL LLEYVSYHTV YINVIKCMID EGATLYRFKH INKYFQKFGN RDPKVVEYIL
     KNGNLVVDND NDDNLINIMP LFPTFSMREL DVLSILKLCK PYIDDINKID KHGCSILYHC
     IKSHSVSLVE WLIDNGADIN IITKYGFTCI TICVILADKY IPEIAELYIK ILEIILSKLP
     TIECIKKTVD YLDDHRYLFI GGNNKSLLKI CIKYFILVDY KYTCSMYPSY IEFITDCEKE
     IADMRQIKIN GTDMLTVMYM LNKPTKKRYV NNPIFTDWAN KQYKFYNQII YNANKLIEQS
     KKIDDMIEEV SIDDNRLSTL PLEIRHLIFS YAFL