ID   TXT1_CYRSC              Reviewed;          81 AA.
AC   P68426;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=U6-theraphotoxin-Hs1a;
DE            Short=U6-TRTX-Hs1a;
DE   AltName: Full=SHT-I {ECO:0000303|PubMed:15483744};
DE   AltName: Full=Toxin 1;
DE   AltName: Full=Toxin-I;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15483744; DOI=10.1093/abbs/36.10.656;
RA   Qiao P., Zuo X.-P., Chai Z.-F., Ji Y.-H.;
RT   "The cDNA and genomic DNA organization of a novel toxin SHT-I from spider
RT   Ornithoctonus huwena.";
RL   Acta Biochim. Biophys. Sin. 36:656-660(2004).
CC   -!- FUNCTION: Binds to the nicotinic acetylcholine receptor. Blocks
CC       neuromuscular transmission. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8)
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: While it is structurally defined as a knottin it lacks the
CC       conserved Cys residue in position 77. {ECO:0000305}.
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DR   AlphaFoldDB; P68426; -.
DR   SMR; P68426; -.
DR   ArachnoServer; AS000418; U6-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035570"
FT   CHAIN           49..81
FT                   /note="U6-theraphotoxin-Hs1a"
FT                   /id="PRO_0000035571"
FT   DISULFID        50..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  9148 MW;  CDE703FA5F58BEDE CRC64;
     MKASMFLALA GLVLLFVVCY ASESEEKEFP RELLSTIFAV DDFKGEEREC LGIFKACTPG
     KNECCSNRVC SGKTRWSKWK L