ID   TXPT6_MACGS             Reviewed;          99 AA.
AC   Q75WH1;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Mu-hexatoxin-Mg1c;
DE            Short=Mu-HXTX-Mg1c;
DE   AltName: Full=Peptide toxin 6 {ECO:0000312|EMBL:BAD13407.1};
DE   Flags: Precursor; Fragment;
OS   Macrothele gigas (Japanese funnel web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Macrothelidae; Macrothele.
OX   NCBI_TaxID=223896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Satake H., Villegas E., Corzo G.;
RT   "cDNA encoding a peptide toxin of Macrothele gigas.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits voltage-gated sodium channels by binding to site 3.
CC       Insecticidal neurotoxin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 09 (magi-1)
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD13407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB121200; BAD13407.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q75WH1; -.
DR   ArachnoServer; AS000415; mu-hexatoxin-Mg1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012627; Toxin_22.
DR   Pfam; PF08092; Toxin_22; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          <1..?
FT                   /evidence="ECO:0000255"
FT   PROPEP          ?..60
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000284759"
FT   CHAIN           61..99
FT                   /note="Mu-hexatoxin-Mg1c"
FT                   /id="PRO_0000284760"
FT   DISULFID        61..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        74..94
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   99 AA;  11647 MW;  F25A660C84168481 CRC64;
     TSQGTTPDKV QLEVNCISNL PNNEVEETDL LRELEMIEEN LFGKELSFVP EENRNSRHKR
     CMGYDIECNE RLHCCADLEC VKTSGRWWYK KTYCRRKSG