ID   TXND3_CIOIN             Reviewed;         653 AA.
AC   Q95YJ5;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Thioredoxin domain-containing protein 3 homolog;
DE   AltName: Full=Dynein intermediate chain 3;
GN   Name=CiIC3;
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=11574167; DOI=10.1016/s0378-1119(01)00661-8;
RA   Padma P., Hozumi A., Ogawa K., Inaba K.;
RT   "Molecular cloning and characterization of a thioredoxin/nucleoside
RT   diphosphate kinase related dynein intermediate chain from the ascidian,
RT   Ciona intestinalis.";
RL   Gene 275:177-183(2001).
CC   -!- FUNCTION: May be required during the final stages of sperm tail
CC       maturation. May act by reducing disulfide bonds within the sperm
CC       components (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis-specific.
CC   -!- DOMAIN: Contains 3 inactive NDK domains that each lack the active His
CC       residue, suggesting that they have no NDP kinase activity.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NDK family.
CC       {ECO:0000305}.
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DR   EMBL; AB057786; BAB68388.1; -; mRNA.
DR   RefSeq; NP_001027618.1; NM_001032446.1.
DR   AlphaFoldDB; Q95YJ5; -.
DR   SMR; Q95YJ5; -.
DR   STRING; 7719.XP_009859668.1; -.
DR   Ensembl; ENSCINT00000013583; ENSCINP00000013583; ENSCING00000006612.
DR   GeneID; 445617; -.
DR   KEGG; cin:445617; -.
DR   CTD; 445617; -.
DR   eggNOG; KOG0888; Eukaryota.
DR   eggNOG; KOG0907; Eukaryota.
DR   GeneTree; ENSGT00940000164537; -.
DR   HOGENOM; CLU_016708_1_0_1; -.
DR   InParanoid; Q95YJ5; -.
DR   OMA; REIQYFF; -.
DR   TreeFam; TF106374; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006165; P:nucleoside diphosphate phosphorylation; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.70.141; -; 3.
DR   InterPro; IPR034907; NDK-like_dom.
DR   InterPro; IPR036850; NDK-like_dom_sf.
DR   InterPro; IPR001564; Nucleoside_diP_kinase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00334; NDK; 3.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PRINTS; PR01243; NUCDPKINASE.
DR   SMART; SM00562; NDK; 3.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF54919; SSF54919; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Disulfide bond;
KW   Redox-active center; Reference proteome; Spermatogenesis.
FT   CHAIN           1..653
FT                   /note="Thioredoxin domain-containing protein 3 homolog"
FT                   /id="PRO_0000120160"
FT   DOMAIN          9..114
FT                   /note="Thioredoxin"
FT   REGION          155..299
FT                   /note="NDK 1"
FT   REGION          300..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..459
FT                   /note="NDK 2"
FT   REGION          459..597
FT                   /note="NDK 3"
FT   REGION          603..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..637
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..41
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   653 AA;  73038 MW;  4D2313C9DB485F93 CRC64;
     MAKRKEVILQ ETLNTQEAWE VAMNSGKLYV VDAHQKWCGP CTAIVGMLKR IKNELGDDLL
     RFATAQVDVI DTLEQYRGKC EPNFLFYGGG ELVAAVRGCN APLVQETIQE TLKNEHKILS
     GEMERKVFRD VYSDTPDQEE EEEDEEEEEG GVVSKQITVA LIKPDVVQNG QVDEILQKIS
     EAGIEVLADE ERMLTVEEAR DFYKNKEEEE YFDQLIDYVT SGPCRVLVLT KGESGEGVVT
     LWRDIIGPFD AAVAKEENPD SLRAIYGTDA TSNALHGSSS TEEAVRELGF FFPDFKPPTY
     RSAKSAASRA SGRRSKTPSQ KPRLQRTLAI IRPDALQAHK DSILQKIDEA GFKIAMQKEM
     VLTREQAESF YSEHKDTDYF EPLVKQMTCG PVLALCLAHD DAVDHWRSML GPKVVADAVE
     EQPDSLRAQF RVEEAEVNML HGSDSAEAAE EELSKIFHVE QTLAVIKPDA IDEKEQIMGK
     LKEAGFMISC QKDMNLSKEI ASEIYKSKEG SEYYDHLIDH MTSGPTLMMV LSAENAVEKL
     RDIMGPTDPE VAKESHPESL RAMFAKSILE NAIHSPSTNE SAQEKIRIVF GDAQFDWDVN
     DMQAEEGEVN ETSGEQPTDE QSGETEKTEE DGEHEGAQSD QQQAVSEAME KEE