ID   TTYH2_XENTR             Reviewed;         534 AA.
AC   Q6P1U2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein tweety homolog 2;
GN   Name=ttyh2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC064869; AAH64869.1; -; mRNA.
DR   RefSeq; NP_989411.1; NM_204080.1.
DR   AlphaFoldDB; Q6P1U2; -.
DR   SMR; Q6P1U2; -.
DR   STRING; 8364.ENSXETP00000020935; -.
DR   PaxDb; Q6P1U2; -.
DR   DNASU; 395050; -.
DR   Ensembl; ENSXETT00000028022; ENSXETP00000028022; ENSXETG00000012828.
DR   GeneID; 395050; -.
DR   KEGG; xtr:395050; -.
DR   CTD; 94015; -.
DR   Xenbase; XB-GENE-854678; ttyh2.
DR   eggNOG; KOG4433; Eukaryota.
DR   InParanoid; Q6P1U2; -.
DR   OrthoDB; 725378at2759; -.
DR   Reactome; R-XTR-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012828; Expressed in liver and 10 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..534
FT                   /note="Protein tweety homolog 2"
FT                   /id="PRO_0000312250"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..388
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        410..534
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        283
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  59519 MW;  77D909DA3BDAE14C CRC64;
     MAAARVEYIA PWWVYWLHNF PHVDLSLRQK SPDFNPKDPG YQQTLLFVAL IVALCAAVNL
     LFVSVYLICL CCCKKEDETE TKKTSSCCVT WTAAVSGLLC CAAVGIGFYG NSETNDGVYQ
     LTYSLDNANH TLAGIDSLVS NTNFKMKEDL DKHLFRLNEI FAARGDYVQS LRFMQQMAGN
     IIQQLTSLPN WQGTSVNLSD IARQTSTIEY YRWLSYLLLF ISYVVICLVT CVGLAKKSKC
     LLLIMLCFGL IALMLSWTSL ALETSSAMGT SDFCVAPDKF IMNMTHDQIT TEVVHYYLYC
     SQSLRNPFQQ ALTVFQRSLT TMQIQVQGLL QFAVPLFPTA QKDLLGIQLL LNTSESNLHQ
     ITALLDCRGL HKDYLEALIG ICYDGVEGML YLGLFSLLAA LAFTAMVCAM PQAWKHLEAR
     DRDYNDIDDE DPFNPQARRI AAHNPNRGQL RSFCSYSSSM GSQASLQPPA PTVSNAPVAE
     YMNQAALFGG NPRYENVPLI GRGSPPPTYS PTMRATYLSM TEEPSSIYSN VFPA