ID   TTDR_ECO57              Reviewed;         310 AA.
AC   Q8XBK9; Q7AAQ2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 3.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=HTH-type transcriptional activator TtdR;
GN   Name=ttdR; OrderedLocusNames=Z4413, ECs3943;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Positive regulator required for L-tartrate-dependent
CC       anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE
CC       operon (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG58194.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37366.1; -; Genomic_DNA.
DR   PIR; F85966; F85966.
DR   PIR; G91121; G91121.
DR   RefSeq; NP_311970.1; NC_002695.1.
DR   RefSeq; WP_000935219.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XBK9; -.
DR   SMR; Q8XBK9; -.
DR   STRING; 155864.EDL933_4281; -.
DR   EnsemblBacteria; AAG58194; AAG58194; Z4413.
DR   EnsemblBacteria; BAB37366; BAB37366; ECs_3943.
DR   GeneID; 916169; -.
DR   KEGG; ece:Z4413; -.
DR   KEGG; ecs:ECs_3943; -.
DR   PATRIC; fig|386585.9.peg.4112; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_16_4_6; -.
DR   OMA; GEIAVNW; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..310
FT                   /note="HTH-type transcriptional activator TtdR"
FT                   /id="PRO_0000262707"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   310 AA;  35341 MW;  4C6ABC8A72A1842E CRC64;
     MLNSWPLAKD LQVLVEIVHS GSFSAAAATL GQTPAFVTKR IQILENTLAT TLLNRSARGV
     ALTESGQRCY EHALEILTQY QRLVDDVTQI KTRPEGMIRI GCSFGFGRSH IAPAITELMR
     NYPELQVYFE LFDRQIDLVQ DNIDLDIRIN DEIPDYYIAH LLTKNKRILC AAPEYLQKYP
     QPQSLQELSR HDCLVTKERD MTHGIWELGN GQEKKSVKVS GHLSSNSGEI VLQWALEGKG
     IMLRSEWDVL PFLESGKLVQ VLPEYAQSAN IWAVYREPLY RSMKLRVCVE FLAAWCQQRL
     GKPDEGYQVM