C42_NPVAC
ID C42_NPVAC Reviewed; 361 AA.
AC P25695;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Protein C42;
DE Short=C42;
DE AltName: Full=P40;
GN ORFNames=ORF101;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HR3;
RA Lu A., Craig A., Carstens E.B.;
RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 308-361.
RC STRAIN=L1;
RX PubMed=3543402; DOI=10.1128/jvi.61.3.661-666.1987;
RA Wilson M.E., Mainprize T.H., Friesen P.D., Miller L.K.;
RT "Location, transcription, and sequence of a baculovirus gene encoding a
RT small arginine-rich polypeptide.";
RL J. Virol. 61:661-666(1987).
RN [4]
RP FUNCTION, INTERACTION WITH E27 AND P78/83, AND SUBCELLULAR LOCATION.
RX PubMed=11711623; DOI=10.1128/jvi.75.24.12331-12338.2001;
RA Braunagel S.C., Guidry P.A., Rosas-Acosta G., Engelking L., Summers M.D.;
RT "Identification of BV/ODV-C42, an Autographa californica
RT nucleopolyhedrovirus orf101-encoded structural protein detected in
RT infected-cell complexes with ODV-EC27 and p78/83.";
RL J. Virol. 75:12331-12338(2001).
RN [5]
RP INTERACTION WITH IE0.
RX PubMed=17626083; DOI=10.1128/jvi.00588-07;
RA Fang M., Dai X., Theilmann D.A.;
RT "Autographa californica multiple nucleopolyhedrovirus EXON0 (ORF141) is
RT required for efficient egress of nucleocapsids from the nucleus.";
RL J. Virol. 81:9859-9869(2007).
RN [6]
RP NUCLEAR LOCALIZATION SIGNAL.
RX PubMed=18287235; DOI=10.1128/jvi.02510-07;
RA Wang Y., Wang Q., Liang C., Song J., Li N., Shi H., Chen X.;
RT "Autographa californica multiple nucleopolyhedrovirus nucleocapsid protein
RT BV/ODV-C42 mediates the nuclear entry of P78/83.";
RL J. Virol. 82:4554-4561(2008).
RN [7]
RP FUNCTION.
RX PubMed=20484515; DOI=10.1128/jvi.00174-10;
RA Li K., Wang Y., Bai H., Wang Q., Song J., Zhou Y., Wu C., Chen X.;
RT "The putative pocket protein binding site of Autographa californica
RT nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin
RT polymerization.";
RL J. Virol. 84:7857-7868(2010).
RN [8]
RP INTERACTION WITH PROTEIN AC102.
RX PubMed=29618641; DOI=10.1128/jvi.00005-18;
RA Zhang Y., Hu X., Mu J., Hu Y., Zhou Y., Zhao H., Wu C., Pei R., Chen J.,
RA Chen X., Wang Y.;
RT "Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-
RT C42 Ubiquitination during Autographa californica Multiple
RT Nucleopolyhedrovirus Infection.";
RL J. Virol. 0:0-0(2018).
CC -!- FUNCTION: Plays a role in host nuclear actin polymerization by
CC recruiting p78/73 protein that is capable of activating an actin-
CC related protein 2/3 complex to initiate nuclear actin polymerization.
CC {ECO:0000269|PubMed:11711623, ECO:0000269|PubMed:20484515}.
CC -!- SUBUNIT: Forms a complex with proteins E27 and p78/83. The interaction
CC with p78/83 mediates nuclear translocation of P78/83. Interacts with
CC protein Ac102. Interacts with IE0. {ECO:0000269|PubMed:11711623,
CC ECO:0000269|PubMed:17626083, ECO:0000269|PubMed:29618641}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:11711623}.
CC Virion {ECO:0000269|PubMed:11711623}.
CC -!- SIMILARITY: Belongs to the baculoviridae C42 protein family.
CC {ECO:0000305}.
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DR EMBL; L22858; AAA66731.1; -; Genomic_DNA.
DR EMBL; U10885; AAB08767.1; -; Genomic_DNA.
DR EMBL; M15370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; F72862; F72862.
DR RefSeq; NP_054131.1; NC_001623.1.
DR PRIDE; P25695; -.
DR GeneID; 1403934; -.
DR KEGG; vg:1403934; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR InterPro; IPR008562; AcMNPV_C42.
DR Pfam; PF05815; DUF844; 1.
PE 1: Evidence at protein level;
KW Host nucleus; Late protein; Reference proteome; Virion.
FT CHAIN 1..361
FT /note="Protein C42"
FT /id="PRO_0000133034"
FT REGION 32..36
FT /note="LXCXE motif"
FT MOTIF 357..360
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:18287235,
FT ECO:0000269|PubMed:20484515"
FT CONFLICT 35
FT /note="D -> V (in Ref. 2; AAB08767)"
FT /evidence="ECO:0000305"
FT CONFLICT 308..327
FT /note="NYAVSNCKFNIEDYNNIFKV -> TMPCPIASSTLRITITYLRL (in
FT Ref. 2; AAB08767)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 41538 MW; B9C28254A646DB46 CRC64;
MSAIALYLEI NKLRLKIDEP MQLAIWPQLF PLLCDEHQSV QLNTDVLINF MMHVARKSQN
TILNNNAAIA SQYAAGNADV VAAPASAQPT PRPVINLFAR ANAAAPAQPS EELINMRRYR
NAARKLIHHY SLNSTSSTEY KISDVVMTMI FLLRSEKYHS LFKLLETTFD DYTCRPQMTQ
VQTDTLLDAV RSLLEMPSTT IDLTTVDIMR SSFARCFNSP IMRYAKIVLL QNVALQRDKR
TTLEELLIER GEKIQMLQPQ QYINSGTEIP FCDDAEFLNR LLKHIDPYPL SRMYYNAANT
MFYTTMENYA VSNCKFNIED YNNIFKVMEN IRKHSNKNSN DQDELNIYLG VQSSNAKRKK
Y
