TSN13_HUMAN
ID TSN13_HUMAN Reviewed; 204 AA.
AC O95857;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Tetraspanin-13;
DE Short=Tspan-13;
DE AltName: Full=Tetraspan NET-6;
DE AltName: Full=Transmembrane 4 superfamily member 13;
GN Name=TSPAN13; Synonyms=NET6, TM4SF13; ORFNames=UNQ260/PRO296;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rubinstein E., Serru V., Dessen P., Boucheix C.;
RT "New tetraspans identified in the EST database.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Kidney, and Stomach;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF120265; AAD17294.1; -; mRNA.
DR EMBL; AF100759; AAD43023.1; -; mRNA.
DR EMBL; AY358995; AAQ89354.1; -; mRNA.
DR EMBL; BC033863; AAH33863.1; -; mRNA.
DR CCDS; CCDS5363.1; -.
DR RefSeq; NP_055214.1; NM_014399.3.
DR AlphaFoldDB; O95857; -.
DR SMR; O95857; -.
DR BioGRID; 117984; 3.
DR STRING; 9606.ENSP00000262067; -.
DR GlyConnect; 1798; 1 N-Linked glycan (1 site).
DR GlyGen; O95857; 4 sites, 1 N-linked glycan (1 site).
DR iPTMnet; O95857; -.
DR PhosphoSitePlus; O95857; -.
DR SwissPalm; O95857; -.
DR BioMuta; TSPAN13; -.
DR EPD; O95857; -.
DR jPOST; O95857; -.
DR MassIVE; O95857; -.
DR PaxDb; O95857; -.
DR PeptideAtlas; O95857; -.
DR PRIDE; O95857; -.
DR ProteomicsDB; 51090; -.
DR Antibodypedia; 25268; 109 antibodies from 22 providers.
DR DNASU; 27075; -.
DR Ensembl; ENST00000262067.5; ENSP00000262067.4; ENSG00000106537.8.
DR GeneID; 27075; -.
DR KEGG; hsa:27075; -.
DR MANE-Select; ENST00000262067.5; ENSP00000262067.4; NM_014399.4; NP_055214.1.
DR CTD; 27075; -.
DR DisGeNET; 27075; -.
DR GeneCards; TSPAN13; -.
DR HGNC; HGNC:21643; TSPAN13.
DR HPA; ENSG00000106537; Low tissue specificity.
DR MIM; 613139; gene.
DR neXtProt; NX_O95857; -.
DR OpenTargets; ENSG00000106537; -.
DR PharmGKB; PA134868624; -.
DR VEuPathDB; HostDB:ENSG00000106537; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157010; -.
DR HOGENOM; CLU_088363_0_0_1; -.
DR InParanoid; O95857; -.
DR OMA; CPPCAPI; -.
DR OrthoDB; 1203231at2759; -.
DR PhylomeDB; O95857; -.
DR TreeFam; TF323367; -.
DR PathwayCommons; O95857; -.
DR SignaLink; O95857; -.
DR BioGRID-ORCS; 27075; 18 hits in 1084 CRISPR screens.
DR ChiTaRS; TSPAN13; human.
DR GeneWiki; TSPAN13; -.
DR GenomeRNAi; 27075; -.
DR Pharos; O95857; Tbio.
DR PRO; PR:O95857; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; O95857; protein.
DR Bgee; ENSG00000106537; Expressed in parotid gland and 202 other tissues.
DR ExpressionAtlas; O95857; baseline and differential.
DR Genevisible; O95857; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR GO; GO:1903169; P:regulation of calcium ion transmembrane transport; IEA:Ensembl.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..204
FT /note="Tetraspanin-13"
FT /id="PRO_0000219258"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D8C2"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 22147 MW; 5928646BCD83C0D6 CRC64;
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA
LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN
DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE
ILGVWLTYRY RNQKDPRANP SAFL
