ID   TSHB_SALSA              Reviewed;         139 AA.
AC   O73824;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Thyrotropin subunit beta;
DE   AltName: Full=Thyroid-stimulating hormone subunit beta;
DE            Short=TSH-B;
DE            Short=TSH-beta;
DE   AltName: Full=Thyrotropin beta chain;
DE   Flags: Precursor;
GN   Name=tshb;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Martin S.A.M., Wallner W., Youngson A.F., Smith T.;
RT   "Differential expression of Atlantic salmon (Salmo salar) thyrotropin beta
RT   subunit mRNA and its cDNA sequence.";
RL   J. Fish Biol. 54:757-766(1998).
CC   -!- FUNCTION: Indispensable for the control of thyroid structure and
CC       metabolism. May play some role in the biological processes of the
CC       immature fishes.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF060566; AAC77908.1; -; mRNA.
DR   RefSeq; NP_001117000.1; NM_001123528.1.
DR   AlphaFoldDB; O73824; -.
DR   SMR; O73824; -.
DR   STRING; 8030.ENSSSAP00000050903; -.
DR   GeneID; 100136355; -.
DR   KEGG; sasa:100136355; -.
DR   CTD; 353223; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa22.
DR   Bgee; ENSSSAG00000050784; Expressed in brain and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..139
FT                   /note="Thyrotropin subunit beta"
FT                   /id="PRO_0000011760"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..127
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..105
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  15449 MW;  9089D770E4268CCF CRC64;
     MELSVAMCGL LCLLFSQAVP MCVPTDYTLY EERRECDFCV AINTTICMGF CYSRDSNMKE
     LAGPRFLIQR GCTYDQVEYR TVILPGCPLH ANPLFTYPVA LSCHCGTCNT DSDECAHKAS
     SGDGARCSKP LRHIYHTLA