TSHB_RAT
ID TSHB_RAT Reviewed; 138 AA.
AC P04652; Q6GTA8;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Thyrotropin subunit beta;
DE AltName: Full=Thyroid-stimulating hormone subunit beta;
DE Short=TSH-B;
DE Short=TSH-beta;
DE AltName: Full=Thyrotropin beta chain;
DE Flags: Precursor;
GN Name=Tshb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Holtzman;
RX PubMed=6086256; DOI=10.1089/dna.1.1984.3.231;
RA Croyle M.L., Maurer R.A.;
RT "Thyroid hormone decreases thyrotropin subunit mRNA levels in rat anterior
RT pituitary.";
RL DNA 3:231-236(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=3839124; DOI=10.1016/0006-291x(85)91061-7;
RA Chin W.W., Muccini J.A. Jr., Shin L.;
RT "Evidence for a single rat thyrotropin-beta-subunit gene: thyroidectomy
RT increases its mRNA.";
RL Biochem. Biophys. Res. Commun. 128:1152-1158(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3017658; DOI=10.1089/dna.1986.5.299;
RA Croyle M.L., Bhattacharya A., Gordon D.F., Maurer R.A.;
RT "Analysis of the organization and nucleotide sequence of the chromosomal
RT gene for the beta-subunit of rat thyrotropin.";
RL DNA 5:299-304(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=3027091; DOI=10.1016/s0021-9258(19)75737-8;
RA Carr F.E., Need L.R., Chin W.W.;
RT "Isolation and characterization of the rat thyrotropin beta-subunit gene.
RT Differential regulation of two transcriptional start sites by thyroid
RT hormone.";
RL J. Biol. Chem. 262:981-987(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 40-138.
RC STRAIN=Wistar Imamichi; TISSUE=Pituitary anterior lobe;
RA Kato Y., Ezashi T., Hirai T., Kato T.;
RT "Strain difference in nucleotide sequences of rat glycoprotein hormone
RT subunit cDNAs and gene fragment.";
RL Zool. Sci. 7:877-885(1990).
CC -!- FUNCTION: Indispensable for the control of thyroid structure and
CC metabolism.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; X01454; CAA25684.1; -; mRNA.
DR EMBL; M10902; AAA42301.1; -; mRNA.
DR EMBL; M13897; AAB59720.1; -; Genomic_DNA.
DR EMBL; M14450; AAA99238.1; -; Genomic_DNA.
DR EMBL; BC058488; AAH58488.1; -; mRNA.
DR EMBL; D00578; BAA00456.1; -; mRNA.
DR PIR; A90954; TTRTB.
DR RefSeq; NP_037248.2; NM_013116.2.
DR AlphaFoldDB; P04652; -.
DR SMR; P04652; -.
DR STRING; 10116.ENSRNOP00000022575; -.
DR GlyGen; P04652; 1 site.
DR PaxDb; P04652; -.
DR Ensembl; ENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793.
DR GeneID; 25653; -.
DR KEGG; rno:25653; -.
DR UCSC; RGD:3910; rat.
DR CTD; 7252; -.
DR RGD; 3910; Tshb.
DR eggNOG; ENOG502S2JW; Eukaryota.
DR GeneTree; ENSGT00940000158152; -.
DR HOGENOM; CLU_126319_0_2_1; -.
DR InParanoid; P04652; -.
DR OMA; PTEYMMH; -.
DR OrthoDB; 1362225at2759; -.
DR PhylomeDB; P04652; -.
DR TreeFam; TF332940; -.
DR Reactome; R-RNO-209822; Glycoprotein hormones.
DR Reactome; R-RNO-209968; Thyroxine biosynthesis.
DR Reactome; R-RNO-375281; Hormone ligand-binding receptors.
DR PRO; PR:P04652; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000016793; Expressed in lung and 11 other tissues.
DR ExpressionAtlas; P04652; baseline and differential.
DR Genevisible; P04652; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; TAS:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051592; P:response to calcium ion; IEP:RGD.
DR GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR GO; GO:0033189; P:response to vitamin A; IEP:RGD.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT CHAIN 21..132
FT /note="Thyrotropin subunit beta"
FT /id="PRO_0000011754"
FT PROPEP 133..138
FT /id="PRO_0000011755"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 22..72
FT /evidence="ECO:0000250"
FT DISULFID 36..87
FT /evidence="ECO:0000250"
FT DISULFID 39..125
FT /evidence="ECO:0000250"
FT DISULFID 47..103
FT /evidence="ECO:0000250"
FT DISULFID 51..105
FT /evidence="ECO:0000250"
FT DISULFID 108..115
FT /evidence="ECO:0000250"
FT CONFLICT 16
FT /note="G -> E (in Ref. 1; CAA25684)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 138 AA; 15505 MW; F8AD7F2426DAEE09 CRC64;
MNAVVLFSVL FALACGQVSS FCIPTEYMMY VDRRECAYCL TINTTICAGY CMTRDINGKL
FLPKYALSQD VCTYRDFTYR TVEIPGCPHH VAPYFSYPVA LSCKCGKCNT DYSDCTHEAV
KTNYCTKPQT FYLGGFSG
