TSH1_DANRE
ID TSH1_DANRE Reviewed; 1158 AA.
AC B3DJM5; Q8QGQ9;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Teashirt homolog 1;
DE AltName: Full=Teashirt-like zinc finger protein;
GN Name=tshz1; Synonyms=sdccag33, tsrt;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 307-1158, INDUCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17035100; DOI=10.1016/j.modgep.2006.08.004;
RA Wang H., Lee E.M.-J., Sperber S.M., Lin S., Ekker M., Long Q.;
RT "Isolation and expression of zebrafish zinc-finger transcription factor
RT gene tsh1.";
RL Gene Expr. Patterns 7:318-322(2007).
CC -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC processes. May act as a transcriptional repressor (Potential).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the 2-somite stage (10 hpf) in the
CC neural keel between rhombomere 7 (r7) and the anterior spinal cord.
CC Between the 2- and 20-somite stages (10-19 hpf), expressed caudally in
CC the developing spinal cord. At 25 somite stage (21 hpf), detected
CC throughout the spinal cord with expression levels gradually decreasing
CC from anterior to posterior. At the prim-5 stage (24 hpf), detected in
CC the pectoral fin buds and in the dorsal forebrain. At the long-pec
CC stage (48 hpf), expressed in the telecephalon, tectum opticum,
CC hindbrain, cerebellum, in the first pharyngeal arch, in the eyes and at
CC very low level in the olfactory placodes. Around the protruding mouth
CC stage (72-96 hpf), some expression is still detected in the eyes and
CC only scattered expression is seen in the tectum, midbrain/hindbrain
CC boundary and hindbrain. By the early larval stage (120 hpf), no
CC expression is detected in the first pharyngeal arch and only low
CC expression is detectable in the telecephalon, midbrain/hindbrain
CC boundary, hindbrain and along the edges of the tectum.
CC {ECO:0000269|PubMed:17035100}.
CC -!- INDUCTION: Up-regulated in embryos by all-trans retinoic acid at the
CC prim-5 stage (24 hpf) in more anterior regions of the neural tube,
CC especially in the midbrain, with weaker expression in the forebrain and
CC in the eye primordium. {ECO:0000269|PubMed:17035100}.
CC -!- SIMILARITY: Belongs to the teashirt C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF242292; AAL88747.1; -; mRNA.
DR EMBL; BC163536; AAI63536.1; -; mRNA.
DR RefSeq; NP_001036211.1; NM_001042746.1.
DR AlphaFoldDB; B3DJM5; -.
DR SMR; B3DJM5; -.
DR STRING; 7955.ENSDARP00000023365; -.
DR PaxDb; B3DJM5; -.
DR PeptideAtlas; B3DJM5; -.
DR PRIDE; B3DJM5; -.
DR Ensembl; ENSDART00000186194; ENSDARP00000148441; ENSDARG00000005026.
DR GeneID; 369196; -.
DR KEGG; dre:369196; -.
DR CTD; 10194; -.
DR ZFIN; ZDB-GENE-030820-3; tshz1.
DR eggNOG; ENOG502RJS7; Eukaryota.
DR GeneTree; ENSGT00950000183051; -.
DR InParanoid; B3DJM5; -.
DR OrthoDB; 106971at2759; -.
DR PhylomeDB; B3DJM5; -.
DR TreeFam; TF328447; -.
DR PRO; PR:B3DJM5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000005026; Expressed in somite and 41 other tissues.
DR ExpressionAtlas; B3DJM5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR027008; Teashirt_fam.
DR InterPro; IPR026808; Tshz1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR12487; PTHR12487; 1.
DR PANTHER; PTHR12487:SF6; PTHR12487:SF6; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1158
FT /note="Teashirt homolog 1"
FT /id="PRO_0000399473"
FT ZN_FING 288..312
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..373
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..485
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 963..1033
FT /note="Homeobox"
FT ZN_FING 1048..1070
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1115..1138
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 70..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 127921 MW; EEBE63EC8A9EF62B CRC64;
MISLILQFML KLHILGTILS HHLFFPLCFV FSAYVPEDEL KAAKIDEEHL QDDGLSLDGQ
DAEYLCNEED DGREQLSYQN SPLSNGTNPD AGYGSPLSDT SDHLADFKST SSKEGQDKEE
VEDMDTDAKL SLQDSLAQMK AVYANLISDA SWSSITKDIM KSKQVSASSI NSTSSSHKGN
NSVANSHAST IASSGASSSS NASASTKTNV TQSSNSTKAT TLTNANNGTI NGANSGGVAY
DWHQAALAKT LQHTPYHLMP EPSLFSTVQL YRQNNKLYGP VFTGASKFRC KDCSAAYDTL
VGLTVHMNET GHYRDDNKDK EEDRGKKWSK PRKRSLMEME GKEDAQKVLK CMYCGHSFES
LQDLSVHMIK TKHYQKVPLK EPMPALASKL VPSTKKRVFQ DLMSPCSPDS ISSTPGIPLA
ETAPTKDPKI SNPYVTANNR YGYQNGASYT WQFEARKAQI LKCMECGSSH DTLQQLTAHM
MVTGHFLKVT NSASKKGKQL VFDPVVEEKI QSIPLPPTTT RLPAPAIKSQ PDSPIHPSIM
DDRKELEEEK FEEPEEKKIK QEKEDPSERV EKSEKLSHYK YLREEDLEES PKGGLDILKS
LENTVSSAIS KAQTGTPTWG GYPSIHAAYQ LQGSVKSSIP AIQSVQIQPT FNASSLKSLT
SDSSTLIHSP SSPSPPPNHK SNVLAMEELV EKVTGKIPSK KDRDEKLTER NSKHLTAELP
SPVLKERKDL PKPDDLTKPT KNGTVDKDLE HTPVREGEYK ESHADNPIKN GTDALKTQVS
NGCGNLGIIT DHSPEQPLVN PLSALQSIMN THLGKASKTV SPLLDPLAML YKISNNMMEK
PMYNPAQVKQ VEPINRYYEN DDDQPMDLTK SKSGIGPTNN CTSTIISNSS ITNSTRPILS
TLAEQVSSPL RENALMDISD MVKNLTGRLT PKSSTPSSIS EKSDADGCAF EDGLEDLSPI
QKRKGRQSNW NPQHLLILQA QFASSLRETP DGKYIITDLG PQERVHICKF TGLSMTTISH
WLANVKYQLR RTGGTKFLKN IDSGHPLFLC SDCASQFRTP STYINHLESH LGFSLKDLSK
LSIDLIRDQQ AVTKMITDKT FRALDLNEED SNSIFQCKLC NRTFVSKHAV KLHLSKTHGK
SPEDHLIFVT ELEKLEKA
