ID   TRRAP_DANRE             Reviewed;        3841 AA.
AC   A0A0R4ITC5;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Transformation/transcription domain-associated protein {ECO:0000312|ZFIN:ZDB-GENE-050809-47};
GN   Name=trrap {ECO:0000312|ZFIN:ZDB-GENE-050809-47};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=31231791; DOI=10.1111/cge.13590;
RA   Xia W., Hu J., Ma J., Huang J., Wang X., Jiang N., Zhang J., Ma Z., Ma D.;
RT   "Novel TRRAP mutation causes autosomal dominant non-syndromic hearing
RT   loss.";
RL   Clin. Genet. 96:300-308(2019).
CC   -!- FUNCTION: Adapter protein, which is found in various multiprotein
CC       chromatin complexes with histone acetyltransferase activity (HAT),
CC       which gives a specific tag for epigenetic transcription activation. May
CC       be required for the mitotic checkpoint and normal cell cycle
CC       progression (By similarity). May play a role in the formation and
CC       maintenance of the auditory system (PubMed:31231791).
CC       {ECO:0000250|UniProtKB:Q9Y4A5, ECO:0000269|PubMed:31231791}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y4A5}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino TRRAP knockdown results in defects in
CC       the inner ear. Morphant larvae show reduced lateral line neuromasts,
CC       decreased number of hair cells per neuromast, and fewer and thinner
CC       stereocilia on the hair cells. In addition, the acoustic startle
CC       response is decreased and sound-induced fast escape reflex is impaired.
CC       {ECO:0000269|PubMed:31231791}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX005075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX571829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO082787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009304957.1; XM_009306682.2.
DR   SMR; A0A0R4ITC5; -.
DR   STRING; 7955.ENSDARP00000110252; -.
DR   Ensembl; ENSDART00000160586; ENSDARP00000137625; ENSDARG00000100623.
DR   GeneID; 557263; -.
DR   KEGG; dre:557263; -.
DR   CTD; 8295; -.
DR   ZFIN; ZDB-GENE-050809-47; trrap.
DR   GeneTree; ENSGT00390000017961; -.
DR   OrthoDB; 7189at2759; -.
DR   Reactome; R-DRE-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-DRE-5689880; Ub-specific processing proteases.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000100623; Expressed in presomitic mesoderm and 26 other tissues.
DR   ExpressionAtlas; A0A0R4ITC5; baseline.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   GO; GO:0035675; P:neuromast hair cell development; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR033317; TRA1/TRRAP.
DR   PANTHER; PTHR11139:SF1; PTHR11139:SF1; 2.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..3841
FT                   /note="Transformation/transcription domain-associated
FT                   protein"
FT                   /id="PRO_0000451069"
FT   DOMAIN          2671..3239
FT                   /note="FAT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00534"
FT   DOMAIN          3482..3805
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   DOMAIN          3809..3841
FT                   /note="FATC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00535"
FT   REGION          491..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2002..2027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3249..3271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3488..3494
FT                   /note="G-loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          3669..3677
FT                   /note="Catalytic loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          3689..3714
FT                   /note="Activation loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   MOTIF           2025..2040
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        493..514
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3251..3270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3841 AA;  435526 MW;  9769FD22B8197227 CRC64;
     MSFVPTPSPT VVDQTTLMKK YLQFVAALTD NNTPDETKLK MMQEVSENFE NVTSSPQYST
     FLEHIIPRFL TFLQDGEVQF LQEKPTQQLR KLVLEIIHRI PTNEHLRSHA KNILSVMFRF
     LEIESEENVL ICLRIIIELH KQFRPPISQE IHHFLDFVKQ IYKELPKVVA RYFENPQVIA
     ENTVPSPEMV GMITSVMVKT APERDDSETR THTIIPRGSL SLKVLAELPI IVVLMYQLYK
     LNIHNVVSEF VPLIMNTIML QVSPQARQHK LFNKELYADF IAAQIKTLSF LAYIIRIYQD
     LVGKYSQQMV KGMLQLLSNC PPETAHLRKE LLIAAKHILT TDLRSQFIPC MDKLFDESIL
     IGSGYTARET LRPLAYSTLA DLVHHVRQNL PLTDLSLAVQ LFAKNIDDES LPSSIQTMSC
     KLLLNLVDCI RSKSEQENGN GRDILMRMLE VFVLKFHTIA RYQLVSIFKK CKPQSEMGVV
     DTGALPGVPA TPTVTTPALP PPAPPTPVTP APPPATSFDR AGEKEDKQTF QVSDCRSLVK
     TLVCGVKTIT WGITSCKAPG EAQFIPNKQL QPKETQIYIK LVKYAMQALD IYQVQIAGNG
     QTYIRVANCQ TVRMKEEKEV LEHFAGVFTM MNPLTFKEIF QTTVPYMVER ISKNYALQIV
     ANSFLANLTT SALFATILVE YLLERLPEMG SNVELSNLYL KLFKLVFGSV SLFAAENEQM
     LKPHLHKIVN SSMELAQSAK EPYNYFLLLR ALFRSIGGGS HDLLYQEFLP LLPNLLQGLN
     MLQSGLHKQH MKDLFVELCL TVPVRLSSLL PYLPMLMDPL VSALNGSQTL VSQGLRTLEL
     CVDNLQPDFL YDHIQPVRAE LMQALWRTLR NPAETISHVA YRVLGKFGGS NRKMLKESQK
     LLYVVTEVQG PSIKAEFTDC KASIQLPMEK AIETALDCLK SANTEPYYRR QAWEVIKCFL
     VAMTSLEDNK HSLYQLLAHP NFTEKWIPNV IISHRYKAQD TPARRTFEQA LTGAFMSAVI
     KDLRPSALPF VASLIRHYTM VAVAQQCGPF LLPCYQSGSQ PSTGMFHSEE NGSKGMDPLV
     LIDAIAICMA YEEKELCKIG EVALAVIFDV ASIILGSKER ACQLPLFSYI VERLCACCYE
     QAWYAKLGGV VSIKFLMERL PLIWVLQNQL TFLKALLFVM MDLTGEVSNG AVAMAKTTLE
     QLLIRCATPL KDEEKTEELL SAQDKSFHLV THDLVREVTS PNSTVRKQAM HSLQVLAQVT
     GKSVTIIMEP HKEVLQDMVP PKKHLLRHQP ANAQIGLMEG NTFCTTLQPR LFTMDLNVME
     HKVFYTELLN LCEAEDAALM KLPCYKSLPS LVPLRIAALN ALAACNYLPQ SREKIIAALF
     KALNSTNSEL QEAGEACMGK FLEGATIEVD QIHTHMRPLL MMLGDYRSLT LNVVNRLTSV
     TRLFPNSFND KFCDQMMQHL RKWMEVVVIT HKGGQRGDGS PAMEGVEEMR ICSAIINLFH
     LIPAAPQTLV KPLLEVVMKT ERAMLIEAGS PFREPLIKFL TRHPSQTVEL FMMEATLNDP
     QWSRMFMSFL KHKDAKPLRD VLASNPNRFV PLLVPAGSAA TVRPGSPSTS TARLDLQFQA
     IKIISIIVKN DEGWLAGQHS LVSQLRRVWV SEAFQERHRK DNMAATNWKE PKLLAFCLLS
     YCKRNYSEIE LLFQLLRAFT GRFLCNMTFL KEYMEEEIPK NYGITHKRAL FFRFVEFNDP
     HFNDELKAKV LQHILNPAFL YSFEKGEGEQ LLGPPNPEGD NPESITSVFI TKVLDPEKQA
     DLADSLRIYL LQFSTLLVEH APHHIHDNNK SRNSKLRRLM TFAWPCLLPK TCVDPACKYS
     GHLLLAHIIA KFAIHKKIVL QVFHSLLKAH TMEARAIVRQ AMAILTPAVP ARMEDGHQML
     THWTRKIIVE EGHTVPQLVH ILHLIVQHFR VYYPVRHHLV QHMISAMQRL GFTPSVTIEQ
     RKLAVDLAEV VIKWELQRIK DQQPESEADP GSVGEGTSGA SAAMKRGMSV DSAQDVKRFR
     TAAGAVGTVF GRSQSIPGTE ALLTKPVEKQ HTDTVVNFLI RIACQVNDST NVAGSPGELL
     SRRCVNLMKT ALRPDMWPSS ELKLQWFDKL LMTVEQPNQA NFSNICTGLE ILCFLLSVLQ
     PPAILSHFKP LQRGIAACMT CGNTKVLRAV HSLLSRLMST FPTEPSTSSV ASKYEELECL
     YAAVGKVIYE GLTNYEKASS ANPTQLFGTL MILKSACSNN SSYIDRLISV FMRSLQKMVR
     EHLSPQPNPG AAETSTVTSE LVMLSLDLVK MRLSVMNMEM RKNFIQVILT SLIEKSPDPK
     ILRAVVKIVE EWVKNSGNPM ATNQVPNPRE KSILLVKMMT YIEKRFPDDL ELNAQFLDLV
     NYVYRDDNLS GSDITSKLEP AFLSGLRCTQ PLIRAKFFEV FDASMKRRVY ERLLYICCSQ
     NWESMGSHFW IKQCTELLLA VCERNTTIGT SCQGSMLPSI TNVINLADSH DRAAFAMATH
     IKQEPREREN SETKEEDVEI DIELAPGDQT SLPKTKEQAE RDAGNQLHML TNRHDKFLDS
     LREVKTGALL NALVQLCHIS TPLAEKTWVQ LFPRLWKILS DRQQHALSGE MGPFLCSGSH
     QAQRDCQPSA LNCFVEAMSQ CVPPIPIRPC VLKYLGKTHN LWLRSTLMLE QQAFEKGLNL
     HIKPKQSTEF YEQESITPPQ QEILDSLAEL YSLLQEEDMW AGLWQKRCKF PETSTAIAYE
     QHGFFEQAQE TYEKAMEKAR KEHNVSPAIF PEYQLWEDHW IRCSKELNQW EPLTEYGQSK
     GHNNPYLVLE CAWRVSNWAA MKEALVQVEL SCPKEMAWKV NMHRGYLAIC HPEEQQLNFI
     ERLVEMASSL AIREWRRLPH IVSHVHTPLL QAAQQIIELQ EAAQINAGLQ PANLGRNTSL
     HDMKTVVKTW RNRLPIVSDD LSHWSSIFMW RQHHYQAIVT AYENNTQHDP NTNNAMLGVH
     ASASAIIQYG KIARKQGLVN VALDILSRIH TIPTVPIVDC FQKIRQQVKC YLQLAGVMGK
     NECMQGLEVI ESTNLKYFTK EMTAEFYALK GMFLAQINKS EEANKAFSAA VQMHDVLVKA
     WAMWGDYLEN IFVKDRQPHL GVSSITCYLH ACRHQNESKS RKYLAKVLWL LSFDDKNTLA
     DAVDKYCIGV PPIQWLAWIP QLLTCLVGSE GKPLLNLISQ VGRVYPQAVY FPIRTLYLTL
     KIEQRERYKS DSGQQQPSSA AAQTHSASDP GPIRATAPMW RCSRIMHMQR ELHPTLLSSL
     EGIVDQMVWF RENWHEEVLR QLQQGLAKCY SVAFEKSGAV SDAKITPHTL NFVKKLVSTF
     GVGLENVSNV STMFSSAASE SLARRAQATA QDPVFQKMKG QFTTDFDFSV PGSMKLHNLI
     SKLKKWIKIL EAKTKQLPKF FLIEEKCRFL SNFSAQTAEV EIPGEFLMPK PTHYYIKIAR
     FMPRVEIVQK HNTAARRLYI RGHNGKIYPY LVMNDACLTE SRREERVLQL LRLLNPCLEK
     RKETTKRHLF FTVPRVVAVS PQMRLVEDNP SSLSLVEIYK QRCAKKGIEH DNPISRYYDR
     LATVQARGTQ ASHQVLRDIL KEVQGNMVPR SMLKEWALHT FPNATDYWTF RKMFTIQLAL
     IGLAEFMLHL NRLNPEMLQI AQDTGKLNVS YFRFDINDAT GDLDANRPVP FRLTPNISEF
     LTTIGVSGPL TASMIAVARC FAQPNFKVDG ILKAVLRDEI IAWHKKTQED TSMPLSPAGQ
     PENMDSQQLV SLVQKAVTAI MTRLHNLAQF EGGESKVNTL VAAANSLDNL CRMDPAWHPW
     L