TRR1_CAEBR
ID TRR1_CAEBR Reviewed; 4115 AA.
AC A8WTE8;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Transcription-associated protein 1 {ECO:0000312|WormBase:CBG02835};
DE Short=Cbr-trr-1 {ECO:0000303|PubMed:24098152};
DE Short=TRRAP-like protein 1 {ECO:0000312|WormBase:CBG02835};
GN Name=trr-1 {ECO:0000312|WormBase:CBG02835};
GN ORFNames=CBG02835 {ECO:0000312|WormBase:CBG02835};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP23759.2, ECO:0000312|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|EMBL:CAP23759.2,
RC ECO:0000312|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
RN [2] {ECO:0000305}
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF LEU-1123 AND GLY-1196.
RX PubMed=24098152; DOI=10.1371/journal.pgen.1003850;
RA Guo Y., Chen X., Ellis R.E.;
RT "Evolutionary change within a bipotential switch shaped the sperm/oocyte
RT decision in hermaphroditic nematodes.";
RL PLoS Genet. 9:E1003850-E1003850(2013).
CC -!- FUNCTION: Influences germ cell fate in hermaphrodites
CC (PubMed:24098152). Acts downstream of tra-2 and tra-3 and through the
CC Tip60 histone acetyltransferase complex to regulate germ cell fate
CC decisions (PubMed:24098152). Required for spermatogenesis and embryonic
CC development (PubMed:24098152). Acts with tra-2 to promote expression of
CC fog-3 and control male tail development (PubMed:24098152). Involved in
CC the negative regulation of vulval development (By similarity).
CC {ECO:0000250|UniProtKB:G5EEV2, ECO:0000269|PubMed:24098152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:G5EEV2}.
CC Note=Localized to condensed chromosomes during pachytene and diakinesis
CC stages of meiosis I in germ cells. {ECO:0000250|UniProtKB:G5EEV2}.
CC -!- DISRUPTION PHENOTYPE: Null mutants display a feminization of the germ
CC line (Fog) phenotype producing oocytes instead of sperm.
CC {ECO:0000269|PubMed:24098152}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000305}.
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DR EMBL; HE601438; CAP23759.2; -; Genomic_DNA.
DR STRING; 6238.CBG02835; -.
DR PRIDE; A8WTE8; -.
DR WormBase; CBG02835; CBP42819; WBGene00025810; Cbr-trr-1.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR InParanoid; A8WTE8; -.
DR OMA; NPIFAMD; -.
DR OrthoDB; 7189at2759; -.
DR Proteomes; UP000008549; Chromosome II.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR014009; PIK_FAT.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Nucleus; Reference proteome;
KW Repeat; Spermatogenesis; TPR repeat.
FT CHAIN 1..4115
FT /note="Transcription-associated protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000432832"
FT REPEAT 1341..1374
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 1820..1853
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT DOMAIN 2808..3421
FT /note="FAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00534"
FT REPEAT 2855..2888
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT DOMAIN 3740..4100
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT DOMAIN 4083..4115
FT /note="FATC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00535"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2678..2701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3746..3752
FT /note="G-loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 3959..3967
FT /note="Catalytic loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 3979..4006
FT /note="Activation loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT COMPBIAS 549..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 1123
FT /note="L->F: In v76; causes a Fog phenotype."
FT /evidence="ECO:0000269|PubMed:24098152"
FT MUTAGEN 1196
FT /note="G->E: In v104; causes a mild Fog phenotype."
FT /evidence="ECO:0000269|PubMed:24098152"
SQ SEQUENCE 4115 AA; 475190 MW; FD5788FFF47E0248 CRC64;
MDPSIPSTSH RSVPPDRGVQ PDRNLHVQEL ENRIQSLVHG GQRDDVKLKE LQDIWASLEN
HFTASSHEKV VEKLVLSILQ LFCNTSPQFI SENNTQMLRK LMLEILLRLS NTDPVKTHSK
EILKQMMRLI GVENEENAIL AIRILIDQGR YGKLDYCREV QSLLLLMRTM VKELAESGRT
AEMFLVRELT VPPATSSEEQ LIAEYLTKCY YAQPVILNAK DGLQGPKFNM IPSAHQSIKV
LLEMPFLVIF FYQNFKTTVQ TEALEFTRLC LDFLNVPVPA DKTKYHDVLT DDFVTVQSKI
LSFVNIMAKI PAFMELLQQN GDSLVSGTMQ MLERCPPDLI SVRREVLLAV KYFTAGEMKS
RFFTMLPRLI SEHFILGTGF TAIELLRVFM YQMLADLMHH TRDTISYELI SHVVFVFCRA
LHDPNNSAQV LIMSARLLNS LAESLCRMES QAPIRDLMLE ILEAQVSKLK VMAVYHIPIL
FQQYGTEIEY EYRNYERESE KPKVNVMKES TQREVPKRRT RKLSMDSVEE LEFLVTDNVN
MTESEQKRNE LPTPTKEHTK KTSPEAILNS LYAASTQPLG LSETRNLIKY VMHTCKYVTG
QLKISRPSTE MYHCVRERDL YERLLRYGIM CMDIYVLPAV KNQAQAHASQ RTKEEKEALE
SLANVFTSID HAIFRELFEK YMDFLIERIY NRNYPLQLMV NTFLVRNEVP FFASTMLSFL
MSRMKMLEVS SDKTALYVKL FKIIFSAIGA NNSTIYQDRM LTNYLPEILK QSTVLALTAR
EPTNYFLLLR SLFRSIGGGA QDMLYGTFLQ LLPNLLQFLN KLTSCQHRIQ MREIFVELCL
TVPVRLSSLL PYLPLLMDPL VCAMNGSPNL VTQGLRTLEL CVDNLQPEYL LENMLPVRGA
LMQGLYRVIS KAPDTASMKV AFRILGKFGG ANRKLLNQPQ LLQVRRFPDS YLNMEFSQMG
LDGNHSLHLP ISELMRVAAD QMRYPADQIF NPNPTNIPSP HVKKCCMELS KAVLLAGLGS
SGSHTVPTKD LPKVLKKLLT GFNVNQRTTE IYICPKENDR EVYVNALLVV AYGIWNKDGL
RQLYSRFFVK IIRQFALMGA IEFVSGNGWM QNADEEGALP LCLDSSVLVD ALITCLSETS
TSFFYGGIMC LRYINETLEL ALPDINQMSK VPLCKYLMEK VLKLCHGPAQ YARAGGINAF
MYMIEHYPRK FIMDFVIDVV DAIMEVLLGL VEEISSGSAD IATDCFKKMM RTYFIQEENQ
EEENLTLASI FVAVFGKHYF HGNDRIRDYM AQLMEYCMIQ SRLETNLDKF YYRFREFFEP
ELIRIMETLP TMSLTDAQGS LDGLQRFVFI CPEGFEFEKD SEIYKRYLVH LLDLAQTDTQ
TINQRNAFKK CETCPSHFLP PFPILHHIDQ MRGSALQCLV IAYDRLRKQL ENTTRDIEDE
QLMSEILAMN SPRITVEQIF ENNESWRRLM TVLLRAITDK DIPDIADKLY PALMRVTPVP
TNIIATFGAN YIRNISRAND ENDPDRTITY HDCRKFSILV ELNPKILVRN IVKNLANHII
KYNMSDSISN ILVMPNEAKE EEVEAYEAEK KRGVRDLEMI GYTAKMLAGC SMEILTAEII
IDITRFAAKF EYTYSQDVLP NWIDDVVKLM NKAPVEVWKF FLLRESVANP ARRSLIRRAI
IFPTSEPLRK VFMQTPEYLE RLIDSNLDNY DNSDERVIID REMFLLSLVD RISRNCHDWL
SDPSLSPIPQ LRAFFNGTEF MDRYSVRSIM VEEAREIRVI SMTEDKYKVP KLMTNIFLRY
LRFVRKYFPV KLIFYRNNIQ DYDMFFNVVS VFMGKFQTDF TFVREYLEVE VIPKMPLWWR
REIFIKVMVM FEENAQKACK DFRILKALQY LILPSLQWAF ERYDTDEIVG SAPIDDSENA
ADAESSNNTE NLVGRLTSVI GAHRLDFSDG MIILFYQLCT LFVQHAPEHI HNNHCKKQGG
RLRNFMLFAW PCLATPNRQD PTLRYTGFFF LANIIERFTI NRKIVLQVFQ QLMTNYQQDT
RDQVRRAIDI LTPALKVRME DGHQQILTQV KKLLIEEGHI LQHIQHILGT IIRNWRVYYH
IRHEILTPLL NAVQRALTMP NSVIEHAQTR KQAIEVCEMI IKWELLKLHK TDHIITDDEA
NEVDKLYEKL RGASSPDRYD FEDQQMKKDL LDSQRVITRE HVDIVVNMLM RFCVMFHTSA
QNNSTSGQQG AELVKKCQLL LRICLRSSVW GDFVNIRTSI LNNYIVVPSE LIPKQNEVQN
PEYVLAANNS QYTIEMLNVI VPILPKPTLK NVLNILQPAL IGVIQSSGHM SRGITQLISR
LGERTSVSTN GLDEFELLNS YIVKYIHDSF STILRCVLIW ISIYSLNPFF RNQNAPVLSV
LGSFTLLRAM CGHEAGFLDN FMPTFLKVMD RVAREHLQFN SRQQPSVQKN LSELTCVCME
LVRQRIDHIG LELKRTTITD VMTELIFKST SERVIQVCAK LIGAMLSPTD MEFSLHTCLQ
QLVRIQSVII SKFKNCKEVI TEFLVVVIKV FENAEYRNSE YGARLWEAFF WGLKSTDPTT
RDSFSAVWEM TWPQMSTADI CHRMKYIMKH QDWSKFKHAF WLKFALWGML RAISKRPKSV
NNPKKKVVML NCATPWRTIE YAARLKEQHM ETDPMIKLEE PEPMEVDQPK NAPAEEPKDN
KLSLDDFLAG QQELLEEAAE FDFADALDTV SQITFGINDN GMTSRIWVTF FKSFWASLQP
REVEDFTALI VPFLSSGVHN QFQTGVQDSV LAVWLEAIGE KVPLPSSLIE FISSKHECWY
TGISILESSI WSIPKQLNNT LLGNINCDRS LTSNIETLES LGALYKELAE FDQYSAIWER
RSVFPETMKA MSALQLGDMD TAASILEQAM NKEMEHLPVP TANAAPPGPN DRQISPIYDR
EYEQWMQMYM SSCSELLQWQ TVAEISNSRE VQDVRGIITA ASHIPDWNLV EDCRSMLSGC
IPPDFHLEYT VFNLMSTVMR LNESVNVPHA RERCKQALQE CIEAHISRFR ALPSVTSYGH
VKILQSMNLV RDIEESMEVR IALLEQPTKM DQSLMMDMKS LMKVYRNRTP TTADDMGFVA
TWYDWRNQIH GMMLQRFEWF DKSSLSTTGN GNQSIVPIHS MAQAQLTVAK HAKSLGFNNL
AKDLLNKLGG LPAIPMMDAV DKVCTYGKTL RALSNNVDDE RSKQELLYEA LEVLEDVRID
DLQKDQITSL LFNRATIHSA LGQTANADRA FSAAVQLTDM KTANVPTGIK LFRQWGNHLN
KLFFDQSQMV SKETSENFGR QALSCYFVAA RVDGDLKARK PIAKILWIAK HLMASGASEA
LNRVIQKHLP SLNLFNWLYW IPQLVTEISH QPNNNFIMVL CRVSLKSESF NSNGASKVSK
SGISGPRKQS KVTPRFPRFL IEQNLNQCDD IAAAHPLQVF YHIREAVSVE DIDAVFAQDY
TEEEMSMDTP DDEAFSNDPP FSRALKICLK YRPTDIRVLH RILKELDQMT ETWVERHLRF
AVAIKDQLFE DFAEQMDARF NEMQFSGAVY ELTQKWKRQL EEDYKFFENN YNLDLLEIRN
RRRVIVTKGY MGTVPSQIMF EKELSQVFTD PPEMKDEFEY VTEITKVIFD QLDIRSPQAP
RPALFVRTVM EWIRIIRRRF DRLPRRVPME ISSPYLARFS HRTGCIEMPY DLLNVLRAKN
HSLNATNQTG QYISMMSRFE PYFEIVMRGG QVTRKIYLRG QTGKSAAFYL KKSIKDERTN
RVPQMFKHVD YLLQNDRETA RRHLSVPSLL QMRVSKNTTF CEIASVQPYA IPQDCSRNYP
ASQIEVMHPY EVLTSTFNGL YSPDDMVMHF YERFADSCSS IGQPLPQNID PSMASQPRLT
EPHHVKNIIY EDFARDMIPF RLLTDYLLAR YPDPVMFYAM RKQFIHSFAV LSIIEYHCNL
SPMTPHQMII SMNTGVLNNP FYRFELGTGQ LMDIEHFAHE VPFRLTPNLM MFVGVAQDGD
LLWSMAAVAR CLMKKEPGAV MRPLLWDEYA NNVNYENMIY ICHAANSYVK CIENKVAMTN
RHDAKVKKDD CNSLIIRAKD SDNLSRMPPT YHAWF
