TRPL_CAEEL
ID TRPL_CAEEL Reviewed; 1027 AA.
AC P34586; P34585; Q8IG03;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2003, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transient-receptor-potential-like protein;
DE AltName: Full=TRP homologous cation channel protein 1;
GN Name=trp-1; Synonyms=strpc1; ORFNames=ZC21.2/ZC21.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Harteneck C., Schultz G.;
RT "Cloning and functional expression of C. elegans TRP isoforms.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Could mediate calcium entry and form a calcium permeant
CC channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ276027; CAC81654.1; -; mRNA.
DR EMBL; FO080281; CCD62572.1; -; Genomic_DNA.
DR PIR; S44872; S44872.
DR RefSeq; NP_001040889.1; NM_001047424.2.
DR AlphaFoldDB; P34586; -.
DR SMR; P34586; -.
DR BioGRID; 41406; 3.
DR STRING; 6239.ZC21.2b; -.
DR PaxDb; P34586; -.
DR PRIDE; P34586; -.
DR EnsemblMetazoa; ZC21.2a.1; ZC21.2a.1; WBGene00006614.
DR GeneID; 176202; -.
DR KEGG; cel:CELE_ZC21.2; -.
DR UCSC; ZC21.2a.2; c. elegans.
DR CTD; 176202; -.
DR WormBase; ZC21.2a; CE33009; WBGene00006614; trp-1.
DR eggNOG; KOG3609; Eukaryota.
DR InParanoid; P34586; -.
DR Reactome; R-CEL-114508; Effects of PIP2 hydrolysis.
DR Reactome; R-CEL-139853; Elevation of cytosolic Ca2+ levels.
DR Reactome; R-CEL-3295583; TRP channels.
DR PRO; PR:P34586; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006614; Expressed in larva and 4 other tissues.
DR ExpressionAtlas; P34586; baseline.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; PTHR10117; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Ion channel; Ion transport; Membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1027
FT /note="Transient-receptor-potential-like protein"
FT /id="PRO_0000215360"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 559..579
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 640..660
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 85..115
FT /note="ANK 1"
FT REPEAT 117..141
FT /note="ANK 2"
FT REPEAT 163..192
FT /note="ANK 3"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 118102 MW; E1B83363A5DE2FAD CRC64;
MTKEGMLSAA GRRFSRCAPS PRPRRNYALA NIPPPAAVHI RTNDMISPEE RRFLEAAELG
NKPTLQECLD YDGDRRLNVN CLDSMGRTAL EIAVDNENME VVELLLQQPD IRIGNALLCA
IREGVYRLVE VLVNHPNITR EMLGDGWSQA LDPSEAASAE YSSDISPVIL AAQLNQFEIL
QMLIRKDASI EKPHRHSCIC ETCDRERLND SLQYSLKRIN TFRALASPAW MSLTSPDPIL
SAFKLSWDLQ RLAFEEHEFK ETYLQLSEQC KQYSCDLLSQ CRSSEEVIAI LNKDGNVNDD
NIDVWASKLS LSRLKLAIKY EQKAFVSHPH CQQLLTSIWY EGIPYRQRSG TWANFFLYAF
LLFLWPIFCL MYILMPKSRL GRLVRSPFMK FFYYSVSFAT FLGLLTWATF EDYRYEKGER
GGMTRASDRG PPATWVESLV FTWVIGMLWS EIKQLWEEGF KRYMRQWWNW LDFLMICLYL
CTISIRLSAY YIFTYREDPY RYTVRTYWTS EEPMLVAEAL FAVGNVFSFA RIIYLFQTNP
YLGPLQISLG CMLVDVAKFC FIFVLIISSF SIGLAQLYWY YDPNTDVCLP GATCKHSSNV
FSSIADSYLT LLWSLFSITK PEDTDVVENH KITQWVGQGM FIMYHCTSII VLLNMLIAMM
SHSFQIINDH ADLEWKFHRT KLWMAHFDEG SSLPPPFNII VTPKSLIYVM NCLFNTVRWL
LGKYTYQKNR NRATIRRPGY SRKRNEMEKS GGHDDDSLKP LTYADIITRL VARFIHQTKK
DMKMDGVNED DLHEIKQDIS SLRYELRDDR RREIVRSSSH IDAVKRDIMR TMSTTSRRPY
GGSMRLPKTR PSVAEESEED DKSDETSSTD EEADETRSRK SSVLYIPPVN STLPGIISEE
APVKKSTKRR ASEADSKLPD RPLSDTYTSS FTPKLLPVFA QPPHSALRKT DTSMSFPING
TALDTSIVKP PRGVLRASQE NLPAVELIET LKKEMNEKLD RLISGISENV KSPSPASHSH
VGFNVEK
