TPBGL_MOUSE
ID TPBGL_MOUSE Reviewed; 384 AA.
AC Q8C013;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Trophoblast glycoprotein-like;
DE Flags: Precursor;
GN Name=Tpbgl; Synonyms=Gm4980;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-384.
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC111086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK032609; BAC27948.1; -; mRNA.
DR CCDS; CCDS57566.1; -.
DR RefSeq; NP_001182458.1; NM_001195529.1.
DR AlphaFoldDB; Q8C013; -.
DR SMR; Q8C013; -.
DR STRING; 10090.ENSMUSP00000137154; -.
DR GlyGen; Q8C013; 1 site.
DR PhosphoSitePlus; Q8C013; -.
DR MaxQB; Q8C013; -.
DR PaxDb; Q8C013; -.
DR PRIDE; Q8C013; -.
DR ProteomicsDB; 259161; -.
DR Ensembl; ENSMUST00000178124; ENSMUSP00000137154; ENSMUSG00000096606.
DR GeneID; 100503386; -.
DR KEGG; mmu:100503386; -.
DR UCSC; uc012fpx.1; mouse.
DR CTD; 100507050; -.
DR MGI; MGI:3646425; Tpbgl.
DR VEuPathDB; HostDB:ENSMUSG00000096606; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000163536; -.
DR HOGENOM; CLU_064866_0_0_1; -.
DR InParanoid; Q8C013; -.
DR OMA; APCPFQC; -.
DR OrthoDB; 785938at2759; -.
DR PhylomeDB; Q8C013; -.
DR TreeFam; TF351115; -.
DR BioGRID-ORCS; 100503386; 2 hits in 33 CRISPR screens.
DR ChiTaRS; Tpbgl; mouse.
DR PRO; PR:Q8C013; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C013; protein.
DR Bgee; ENSMUSG00000096606; Expressed in vastus lateralis and 149 other tissues.
DR Genevisible; Q8C013; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 2.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..384
FT /note="Trophoblast glycoprotein-like"
FT /id="PRO_0000419457"
FT TOPO_DOM 31..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 61..84
FT /note="LRR 1"
FT REPEAT 95..118
FT /note="LRR 2"
FT REPEAT 119..142
FT /note="LRR 3"
FT REPEAT 173..196
FT /note="LRR 4"
FT REPEAT 198..219
FT /note="LRR 5"
FT REGION 361..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 31..37
FT /evidence="ECO:0000250"
FT DISULFID 35..47
FT /evidence="ECO:0000250"
FT DISULFID 240..266
FT /evidence="ECO:0000250"
FT DISULFID 242..287
FT /evidence="ECO:0000250"
SQ SEQUENCE 384 AA; 41085 MW; F9029D80B116B832 CRC64;
MAPRAGQRGL WSPLPGLLLL AAALSRPAAP CPFQCYCFGS PRLMLRCASG AELRQPPRDV
PPDARNLTIV GANLTVLRAA AFAGGGEGAT DGVRLPLLTA LRLTHNNIEV VEDGAFDGLP
SLAALDLSHN PLRALGYRAF RGLPALRSLQ LNHALARGSP GMLDALDAAL APLAELRLLG
LVGNALSRLP LAALRLPRLE QLDARVNALA GLGPDELSAL ERDGDLPQPR LLLADNPLSC
GCTSRPLLAW LHNATERVPD ARRLRCASPR VLLDRPLIDL DEARLGCSDG DAHESGEGID
VAGPELEASY VFFGLVLALI GLIFLMVLYL NRRGIQRWMH NLREACRDQM EGYHYRYEQD
ADPRRAPAPA APAGSRATSP GSGL
